Primary Adrenal Plasmablastic Lymphoma presenting as lymphomatous meningitis – A diagnostic perplexity

Cytopathology ◽  
2021 ◽  
Author(s):  
Priya Pathak ◽  
Deepak Rajaram Madi ◽  
Santosh P V Rai ◽  
Shafir Kassim ◽  
S Anusha
Keyword(s):  
Plasmablastic Lymphoma ◽  
Lymphomatous Meningitis

Plasmablastic Myeloma Versus Plasmablastic Lymphoma; Is MYC Rearrangement Helpful Towards A Precise Diagnosis?

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S105-S105
Author(s):  
M Khedr ◽  
Y Yusuf ◽  
L Aftab
Keyword(s):  
Reference Range ◽  
Final Diagnosis ◽  
Plasmablastic Lymphoma ◽  
Bone Lesions ◽  
Molecular Testing ◽  
Diagnostic Challenge ◽  
Plasma Cell Neoplasm ◽  
Hiv Antibodies ◽  
Precise Diagnosis ◽  
Diagnostic Work

Abstract Introduction/Objective Plasmablastic myeloma (PBM) is a rare and aggressive plasma cell neoplasm. Differentiating PBM from plasmablastic lymphoma (PBL) represents a diagnostic challenge, as both diseases have overlapping cytomorphologic and immunophenotypic features. Genetic mutations in MYC occur in a majority of PBL cases but rarely in PBM, thus can theoretically be used to differentiate between both neoplasms. Methods We report a case of a 53-year-old female who presented with a rapidly growing mass in her right mandible. Biopsy revealed circumscribed nodules of immunoblastic cells with moderate cytoplasm, large vesicular nuclei and large prominent nucleoli. Apoptotic debris and brisk mitoses were present. Molecular testing revealed a C-MYC rearrangement. The location of the neoplasm and the above described morphological features were suggestive of PBL, especially with a positive C-MYC rearrangement. The neoplastic cells were positive for CD138, MUM1,CD56 and kappa; and negative for CD45, CD20, PAX5, CD3, CD5, CD30, EBER-ISH, HHV8, ALK-1, Lambda, EMA, CD21, CD23, pancytokeratin, CK20, CK7, Cam5.2, chromogranin, synaptophysin, HMB45, S100, P16, P40. MIB-1 showed high positivity, approximately 95%. Results Patient underwent further diagnostic work up, her HIV antibodies result were negative however, she was found to be anemic (Hemoglobin 6.6 g/dl; reference range 12-16 g/dl) and hypercalcemic (Calcium 12.3 mg/dl; reference range 8.5-10.5 mg/dl). PET scan revealed multiple hypermetabolic lytic bone lesions. The bone marrow biopsy showed 80% cellularity with extensive involvement by atypical plasmacytic cells forming large clusters. The patient’s final diagnosis was PBM. Conclusion Differentiating PBM from PBL is essential as treatment is different. Although MYC rearrangement in PBM is not common, it has been demonstrated and therefore should not be used to exclude this diagnosis. Here, we highlight the importance of correlating detailed clinical, radiological, laboratory, histological and genetics data for reaching the final diagnosis.

scholarly journals Complete response to pembrolizumab and radiation in a patient with HIV ‐negative, EBV ‐positive plasmablastic lymphoma

2021 ◽  
Author(s):  
Jorge J. Castillo ◽  
John Lamacchia ◽  
Joel Silver ◽  
Catherine A. Flynn ◽  
Shayna Sarosiek
Keyword(s):  
Complete Response ◽  
Plasmablastic Lymphoma ◽  
Hiv Negative

scholarly journals Long-term survivor of human immunodeficiency virus-associated plasmablastic lymphoma

2013 ◽  
Vol 34 (2) ◽  
pp. 96 ◽  
Author(s):  
Atul Sharma ◽  
T. V. S. V. G. K. Tilak ◽  
Rakesh Lodha ◽  
MC Sharma ◽  
Deepak Dabkara
Keyword(s):  
Human Immunodeficiency Virus ◽  
Plasmablastic Lymphoma ◽  
Immunodeficiency Virus ◽  
Term Survivor

scholarly journals Non-Hodgkin’s Plasmablastic Lymphoma as Initial Presentation of Human Immunodeficiency Virus

2021 ◽  
Vol 9 ◽  
pp. 232470962110146
Author(s):  
Roopam Jariwal ◽  
Nadia Raza ◽  
Janpreet Bhandohal ◽  
Everardo Cobos
Keyword(s):  
Human Immunodeficiency Virus ◽  
Acquired Immunodeficiency Syndrome ◽  
Initial Presentation ◽  
Plasmablastic Lymphoma ◽  
Healthy Male ◽  
Immunodeficiency Virus ◽  
Life Threatening ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Head Neck

Plasmablastic lymphoma (PBL) is a subtype of non-Hodgkin’s lymphoma that manifests in patients with the diagnosis of human immunodeficiency virus (HIV), more prominently in the head, neck, and oral mucosal region. The diagnosis of this rare lymphoma serves as a concomitant diagnosis of acquired immunodeficiency syndrome. The case is of a 33-year-old previously healthy male, with an unknown diagnosis of HIV with a painful right mandibular mass. He was subsequently diagnosed with PBL and HIV. This case of PBL illustrates the importance of linking a rare and potentially life-threatening diagnosis as a possible first manifestation of HIV.

scholarly journals Plasmablastic Lymphoma Following Transplantation

2013 ◽  
Vol 26 (2) ◽  
pp. 152-155 ◽  
Author(s):  
Michael J. Van Vrancken ◽  
Latoya Keglovits ◽  
John Krause
Keyword(s):  
Plasmablastic Lymphoma

HHV8 in Plasmablastic Lymphoma

2008 ◽  
Vol 32 (1) ◽  
pp. 172 ◽  
Author(s):  
Jacqueline Goedhals ◽  
Catherine A. Beukes ◽  
Diana Hardie
Keyword(s):  
Plasmablastic Lymphoma

Plasmablastic lymphoma of the oral cavity in an HIV-positive patient: staging with 18F-FDG PET/CT

2011 ◽  
Vol 52 (9) ◽  
pp. 970-972 ◽  
Author(s):  
William Makis ◽  
Anthony Ciarallo ◽  
Robert Lisbona
Keyword(s):  
Oral Cavity ◽  
Aggressive Behavior ◽  
Fdg Pet ◽  
Poor Prognosis ◽  
Plasmablastic Lymphoma ◽  
Hiv Positive ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Rare Report

Plasmablastic lymphoma of the oral cavity is a very rare and only recently recognized entity that has been identified almost exclusively in HIV-infected individuals. It has a predilection for the oral cavity, often exhibits very aggressive behavior and has a poor prognosis. The use of 18F-FDG PET/CT in the evaluation of HIV-associated lymphomas is a recent development, and its use in the staging of plasmablastic lymphoma of the oral cavity has not been previously reported. This rare report highlights the usefulness of 18F-FDG PET/CT in the staging of plasmablastic lymphoma of the oral cavity.

Unique presentation of a plasmablastic lymphoma superficially involving the entire large bowel

2015 ◽  
Vol 211 (12) ◽  
pp. 1030-1033 ◽  
Author(s):  
Magda Zanelli ◽  
Moira Ragazzi ◽  
Riccardo Valli ◽  
Loredana De Marco ◽  
Paolo Cecinato ◽  
...  
Keyword(s):  
Large Bowel ◽  
Plasmablastic Lymphoma
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