Liquid‐based endometrial cytology using SurePath™ is not inferior to suction endometrial tissue biopsy for detecting endometrial malignancies: Midterm report of a multicentre study advocated by Japan Association of Obstetricians and Gynecologists

Cytopathology ◽  
2019 ◽  
Vol 30 (2) ◽  
pp. 223-228
Author(s):  
Yasuo Hirai ◽  
Kimihiko Sakamoto ◽  
Hiroyuki Fujiwara ◽  
Masaharu Kamata ◽  
Takao Tamura ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Endometrial Tissue ◽  
Tissue Biopsy ◽  
Endometrial Cytology

Liquid-Based Endometrial Cytology Using SurePath™ Is Not Inferior to Suction Endometrial Tissue Biopsy in Clinical Performance for Detecting Endometrial Cancer Including Atypical Endometrial Hyperplasia

2017 ◽  
Vol 61 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Fumiko Yanaki ◽  
Yasuo Hirai ◽  
Azusa Hanada ◽  
Ken Ishitani ◽  
Hideo Matsui
Keyword(s):  
Endometrial Hyperplasia ◽  
Clinical Performance ◽  
Endometrial Tissue ◽  
Final Histology ◽  
Endometrial Cells ◽  
Atypical Endometrial Hyperplasia ◽  
Tissue Biopsy ◽  
Biopsy Specimens ◽  
Detection Tool ◽  
Endometrial Cytology

Objective: We evaluated the clinical performance of liquid-based endometrial cytology (SurePath™) for detecting endometrial malignancies by comparison with the performance of suction endometrial tissue biopsy. Study Design: From November 2011 to May 2013, we consecutively collected 1,118 liquid-based endometrial cytology specimens and 674 suction endometrial tissue biopsy specimens. Results: The rate of nonpositive final histology in nonpositive liquid-based endometrial cytology (98.2%) was higher than the rate of nonpositive final histology in nonpositive suction endometrial tissue biopsy (97.0%). None of the clinical performance values of liquid-based endometrial cytology for detecting the endometrial malignancies were statistically inferior to those of the suction endometrial tissue biopsy. When the positivity threshold was more than “atypical endometrial cells of undetermined significance,” the rate of positive liquid-based endometrial cytology from cases with a positive final histology (84.5%) was higher than the rate of positive suction endometrial tissue biopsy from cases with a positive final histology (69.8%). However, there were still no significant differences among all the performance values. Conclusions: Our liquid-based endometrial cytology would be more appropriate in various clinical situations as the initial detection tool for endometrial malignancies, rather than suction endometrial tissue biopsy. In addition, it could be used in screening for endometrial malignancies on a broader scale.

Incidence of fractures in 2-18 years old affluent Indian children: a multicentre study

2013 ◽  
Author(s):  
Ekbote Veena ◽  
Khadilkar Anuradha ◽  
Pillay Deepa ◽  
Chiplonkar Shashi ◽  
Zulf Mughal M ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Indian Children
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