The enigma of a pulmonary papillary lesion

Cytopathology ◽  
2018 ◽  
Vol 29 (6) ◽  
pp. 585-586
Author(s):  
Rajesh Kumar ◽  
Nalini Gupta ◽  
Navneet Singh ◽  
Rakesh Kumar Vasishta ◽  
Arvind Rajwanshi
Keyword(s):  
Papillary Lesion

scholarly journals Mixed Invasive Apocrine Papillary/Micropapillary Carcinoma of the Breast: Another Brick in the Triple-Negative Wall

2020 ◽  
pp. 106689692095492
Author(s):  
Luca Cima ◽  
Nicola Mirabassi ◽  
Chiara Sartori ◽  
Francesco Giuseppe Carbone ◽  
Luca Morelli ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Myoepithelial Cell ◽  
Triple Negative ◽  
Cell Layer ◽  
Malignant Potential ◽  
Papillary Lesion ◽  
Micropapillary Carcinoma ◽  
Uncertain Malignant Potential ◽  
Luminal A ◽  
Architectural Features

Pure invasive papillary carcinoma (IPC) is a rare subtype of breast carcinoma with good prognosis compared with classical invasive breast carcinoma (IBC) of no special type. The majority of IPC are estrogen receptor and progesterone receptor (ER/PR) positive and HER2 negative (luminal A-like). We report the case of a 72-year-old women who was referred to the Senology Clinic for a routine workup following surgery for an intraductal papilloma. The core needle biopsy (CNB) showed a lesion mainly composed of irregular papillae and micropapillae with apocrine epithelial cells of low-to-intermediate nuclear grade, without a myoepithelial cell layer within the papillae and at the periphery, as demonstrated with multiple immunostains. The diagnosis of apocrine papillary lesion of uncertain malignant potential was made. The subsequent lumpectomy showed an IBC with the same cyto-architectural features as the CNB. In addition, lymphovascular invasion and papillary/micropapillary apocrine in situ lesion were noted. Notably, the tumor was ER/PR and HER2 negative and strongly positive for androgen receptor. A final diagnosis of mixed apocrine papillary/micropapillary carcinoma with triple-negative status was made. To the best of our knowledge, this is the first report of an IBC with these features. Breast pathologists should be aware of this entity when dealing with CNB samples characterized by a complex papillary lesion with apocrine atypia that lacks a myoepithelial cell layer on multiple immunostains. These lesions should be classified at least as of uncertain malignant potential based on the cyto-architectural features prompting a surgery for removal.

scholarly journals Atypical papillary lesions after core needle biopsy and subsequent breast carcinoma

2011 ◽  
Vol 5 (2) ◽  
pp. 243-248
Author(s):  
Tuenchit Khamapirad ◽  
Caitlin Andrews ◽  
Jenjeera Prueksadee ◽  
Morton Leonard ◽  
Louisea Bonoan-Deomampo ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Papillary Lesion ◽  
Architectural Distortion ◽  
Core Needle ◽  
Multiple Imaging ◽  
Papillary Lesions ◽  
Benign Papilloma

Abstract Background: Papillary lesions of the breast cause diagnostic problem because papillary structures are found in benign and malignant processes. Core needle biopsy is important to make an initial diagnosis, but it still has potential pitfalls. Comparison between core needle biopsy and excisional biopsy can predict the possibility of malignant change in atypical papillary lesions. Objective: Evaluate the concordance between core needle biopsy and excisional results in atypical papillary lesions of the breast. Materials and methods: The pathology database of University of Texas Medical Branch at Galveston, USA was searched for patients with atypical papillary lesions at core needle biopsy who subsequently underwent surgical excision. Pathology reports from the excisional biopsies was also examined to assign each case to one of three categories, downgrade to benign papilloma, no change (remained atypical papillary lesion), and upgrade to carcinoma. The mammograms and ultrasounds were reviewed for each case. They characterized the lesions according to multiple imaging criteria. Results: Twenty-four patients with atypical papillomas at core biopsy subsequently underwent surgical excision. The lesions were downgraded to benign papilloma in 25%, remained atypical papillary lesion in 33%, and upgraded to carcinoma in 42%. On mammographic presentations (n = 23), masses were in 61%, architectural distortion in 4.3%, mass with calcifications in 9%, mass with architectural distortion and calcifications in 4.3%, calcifications alone in 17.4%, and architectural distortion and calcifications in 4.3%. On ultrasound findings (n = 21), solid masses were in 90%, intracystic masses in 10%, peripheral in locations in 81%, and subareolar in location in 19%. Conclusion: Due to the high upgrade rate of atypical papillary lesions to carcinoma (42%), excision of all atypical papillary lesions with wide excision margin is recommended for cases with pathologic diagnosis of atypical papillary lesion on core-needle biopsy.

The management of papillary lesion of the breast by core needle biopsy

2009 ◽  
Vol 35 (1) ◽  
pp. 21-24 ◽  
Author(s):  
H.S. Tseng ◽  
Y.L. Chen ◽  
S.T. Chen ◽  
Y.C. Wu ◽  
S.J. Kuo ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Papillary Lesion ◽  
Core Needle

scholarly journals Bladder tumours in children: An interesting case report of TCC with a partial inverted growth pattern

2014 ◽  
Vol 86 (3) ◽  
pp. 222 ◽  
Author(s):  
Davide Abed El Rahman ◽  
Giuseppe Salvo ◽  
Carlotta Palumbo ◽  
Bernardo Rocco ◽  
Francesco Rocco
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Growth Pattern ◽  
Bladder Wall ◽  
Transitional Cell ◽  
Interesting Case ◽  
Papillary Lesion ◽  
Low Grade ◽  
Older Individuals ◽  
Carcinoma Of The Bladder

Bladder urothelial carcinoma is typically a disease of older individuals and rarely occurs below the age of 40 years. There is debate and uncertainty in the literature regarding the clinicopathologic and prognostic characteristics of bladder urothelial neoplasms in younger patients compared with older patients, although no consistent age criteria have been used to define "younger" age group categories. We report on a 16 years old girl with transitional cell carcinoma of the bladder with a partial inverted growth pattern who presented with gross hematuria. Ultrasonography revealed a papillary lesion in the bladder; cystoscopic evaluation showed a 15 mm papillary lesion with a thick stalk located in the left bladder wall. Pathologic evaluation of the specimen was reported as “low grade transitional cell carcinoma of the bladder with a partial inverted growth pattern”.

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