Significance of decoy cells for indicating viral cytopathic effect in urine cytology

Cytopathology ◽  
2015 ◽  
Vol 27 (3) ◽  
pp. 220-221 ◽  
Author(s):  
M. Kimura ◽  
T. Hayashi
Keyword(s):  
Cytopathic Effect ◽  
Urine Cytology ◽  
Viral Cytopathic Effect

Herpes simplex viral cytopathic effect in urine cytology

2011 ◽  
Vol 41 (1) ◽  
pp. 61-62 ◽  
Author(s):  
Robert E. LeBlanc ◽  
Zahra Maleki
Keyword(s):  
Herpes Simplex ◽  
Cytopathic Effect ◽  
Urine Cytology ◽  
Viral Cytopathic Effect

scholarly journals Mouse Macrophages Carrying Both Subunits of the Human Interferon-γ (IFN-γ) Receptor Respond to Human IFN-γ but Do Not Acquire Full Protection against Viral Cytopathic Effect

1996 ◽  
Vol 271 (51) ◽  
pp. 32659-32666 ◽  
Author(s):  
David Lembo ◽  
Paola Ricciardi-Castagnoli ◽  
Gottfried Alber ◽  
Laurence Ozmen ◽  
Santo Landolfo ◽  
...  
Keyword(s):  
Cytopathic Effect ◽  
Interferon Γ ◽  
Human Interferon ◽  
Mouse Macrophages ◽  
Ifn Γ ◽  
Full Protection ◽  
Viral Cytopathic Effect

Dimeric Macrocyclic Polyamines with Potent Inhibitory Activity against Human Immunodeficiency Virus

1995 ◽  
Vol 6 (5) ◽  
pp. 337-344 ◽  
Author(s):  
Y. Inouye ◽  
T. Kanamori ◽  
M. Sugiyama ◽  
T. Yoshida ◽  
T. Koike ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cytopathic Effect ◽  
Syncytium Formation ◽  
Physiological Conditions ◽  
Structure Activity ◽  
Immunodeficiency Virus ◽  
Macrocyclic Polyamines ◽  
Anti Hiv ◽  
Viral Cytopathic Effect ◽  
Potent Inhibitory Activity

The structure-activity relationships of monomeric and dimeric macrocyclic polyamines were studied in an attempt to find potent inhibitors of human immunodeficiency virus (HIV) types 1 and 2. In general, dimeric polyamines are superior as HIV inhibitors to their monomeric counterparts, and the activity of a dimer is proportional to that of its constituent monomers. For the monomeric compounds, the amount of positive charge on the monomer rings under physiological conditions was more important for anti-HIV activity than the ring size. On the basis of these findings, the 14-membered tetraamine cyclam was selected as the component of dimeric compounds with potentially high activity. Of the series of newly synthesized bicyclams, in which the monomeric cyclams were linked at each C-6 position, a compound with an aIkyI chain bridge three carbons in length was found to exhibit the maximum anti-HIV activity. For one particular strain (HIV-2GH-1), syncytium formation was inhibited by the bicyclams at a similar concentration to that required to inhibit the viral cytopathic effect.

scholarly journals Synthesis and Evaluation of Anti-Rhinovirus 1B Activity of Oxazolinyl-Isoflavans and -3(2H)-Isoflavenes

1992 ◽  
Vol 3 (4) ◽  
pp. 195-202 ◽  
Author(s):  
N. Desideri ◽  
C. Conti ◽  
I. Sestili ◽  
P. Tomao ◽  
M. L. Stein ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Antiviral Activity ◽  
Cytopathic Effect ◽  
Potent Inhibitor ◽  
Therapeutic Index ◽  
Intermediate Compound ◽  
Plaque Formation ◽  
Interesting Compound ◽  
Viral Cytopathic Effect

Oxazolinyl-isoflavans and −3(2H)-isoflavenes, substituted or not with a chlorine atom, were synthesized in order to compare their anti-rhinovirus activity with that of previously studied analogous compounds. The activity of the oxazolines and of the esters and acids, which are intermediates in the synthesis, was studied in vitro against rhinovirus serotype 1B infection in HeLa cells. The ability of various non cytotoxic concentrations to interfere with the development of the viral cytopathic effect and plaque formation was examined. All the tested compounds exerted a significant antiviral activity, and most of them were as active as some representative compounds of the oxazolinyl-phenoxyalkylisoxazole (WIN) series. 6-Oxazolinylisoflavan (VI) appeared to be the most interesting compound due to its high activity and therapeutic index. Among the substituted isoflavans and isoflavenes tested so far, the intermediate compound 6-chloro-3 (2H)-isoflavene-4′-carboxylic acid (XIX) was unexpectedly the most potent inhibitor of rhinovirus 1B plaque formation.

scholarly journals Efficacy of microbicides for inactivation of Ebola–Makona virus on a non-porous surface: a targeted hygiene intervention for reducing virus spread

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Todd A. Cutts ◽  
Catherine Robertson ◽  
Steven S. Theriault ◽  
Raymond W. Nims ◽  
Samantha B. Kasloff ◽  
...  
Keyword(s):  
Infection Prevention ◽  
Ebola Virus ◽  
Cytopathic Effect ◽  
Infectious Virus ◽  
Hard Water ◽  
Infection Prevention And Control ◽  
Environmental Surfaces ◽  
Hygiene Intervention ◽  
And Control ◽  
Viral Cytopathic Effect

Abstract Microbicides play critical roles in infection prevention and control of Ebola virus by decontaminating high-touch environmental surfaces (HITES), interrupting the virus-HITES-hands nexus. We evaluated the efficacy of formulations containing different microbicidal actives for inactivating Ebola virus–Makona strain (EBOV/Mak) on stainless-steel carriers per ASTM E2197-11. Formulations of sodium hypochlorite (NaOCl) (0.05–1%), ethanol (70%), chloroxylenol (PCMX) (0.12–0.48% by weight) in hard water, and a ready-to-use disinfectant spray with 58% ethanol (EDS), were tested at contact times of 0, or 0.5 to 10 min at ambient temperature. EBOV/Mak was inactivated (> 6 log10) by 70% ethanol after contact times ≥ 2.5 min, by 0.5% and 1% NaOCl or EDS (> 4 log10) at contact times ≥ 5 min, and by 0.12–0.48% PCMX (> 4.2 log10) at contact times ≥ 5 min. Residual infectious virus in neutralized samples was assessed by passage on cells and evaluation for viral cytopathic effect. No infectious virus was detected in cells inoculated with EBOV/Mak exposed to NaOCl (0.5% or 1%), PCMX (0.12% to 0.48%), or EDS for ≥ 5 min. These results demonstrate ≥ 6 log10 inactivation of EBOV/Mak dried on prototypic surfaces by EDS or formulations of NaOCl (≥ 0.5%), PCMX (≥ 0.12%), or 70% ethanol at contact times ≥ 5 min.

Vanishing Viral Cytopathic Effect Diagnoses in the Cytopatholoogy Laboratory

2021 ◽  
Vol 10 (5) ◽  
pp. S45
Author(s):  
Sindhuja Murali Kilapandal Venkatraman ◽  
Paolo Gattuso ◽  
Lin Cheng
Keyword(s):  
Cytopathic Effect ◽  
Viral Cytopathic Effect

scholarly journals Assay of human interferon in Vero cells by several methods

1979 ◽  
Vol 9 (4) ◽  
pp. 471-475
Author(s):  
P C Ferreira ◽  
M L Peixoto ◽  
M A Silva ◽  
R R Golgher
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Sindbis Virus ◽  
Reduction Method ◽  
Cytopathic Effect ◽  
Vero Cells ◽  
Human Interferon ◽  
Inhibition Assay ◽  
Vesicular Stomatitis ◽  
Viral Cytopathic Effect

Four methods for the assay of human interferon in Vero cells were compared based on the inhibition of viral cytopathic effect (CPE) in tubes, the inhibition of CPE in microplates, the reduction of plaques, and the inhibition of quantitative hemadsorption. For inhibition of CPE, Sindbis virus, vesicular stomatitis virus, poliovirus type 2, and vaccinia virus were used for challenge. In the plaque reduction method, Sindbis virus, vesicular stomatitis virus, and poliovirus were employed, and Newcastle disease virus was used in the quantitative hemadsorption assay. Sindbis virus was most susceptible to interferon in those tests measuring inhibition of CPE, but vesicular stomatitis virus was as sensitive in the plaque reduction method. Highest titers of interferon were recorded in microplates, especially with Sindbis virus as the challenge agent, followed by the quantitative inhibition assay. The CPE inhibition method was the simplest, and the quantitative hemadsorption assay was the most rapid to perform. Reproducibilities, as shown by the coefficient of variation, were 15, 39, and 59% for plaque reduction, CPE inhibition in tubes, and CPE inhibition in microplates, respectively.

scholarly journals ATeam technology for detecting early signs of viral cytopathic effect

2020 ◽  
Vol 82 (3) ◽  
pp. 387-393
Author(s):  
Karla Cristine C. DOYSABAS ◽  
Mami OBA ◽  
Tomoki ISHIBASHI ◽  
Hideki SHIBATA ◽  
Hitoshi TAKEMAE ◽  
...  
Keyword(s):  
Cytopathic Effect ◽  
Early Signs ◽  
Viral Cytopathic Effect
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