scholarly journals Repeatability of wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography

2019 ◽  
Vol 102 (3) ◽  
pp. 327-334 ◽  
Author(s):  
Hosein Hoseini‐Yazdi ◽  
Stephen J Vincent ◽  
Michael J Collins ◽  
Scott A Read ◽  
David Alonso‐Caneiro
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Enhanced Depth Imaging ◽  
Wide Field ◽  
Optical Coherence ◽  
Depth Imaging ◽  
Imaging Optical Coherence Tomography ◽  
Thickness Measurements

The effect of obesity and insulin resistance on macular choroidal thickness in a pediatric population as assessed by enhanced depth imaging optical coherence tomography

2018 ◽  
Vol 31 (8) ◽  
pp. 855-860 ◽  
Author(s):  
Pinar Topcu-Yilmaz ◽  
Nesibe Akyurek ◽  
Erkan Erdogan
Keyword(s):  
Insulin Resistance ◽  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Enhanced Depth Imaging ◽  
Model Assessment ◽  
Optical Coherence ◽  
Obese Children ◽  
Depth Imaging ◽  
Imaging Optical Coherence Tomography ◽  
Thickness Measurements

Abstract Background: The purpose of this study was to evaluate the macular choroidal thickness in obese children with and without insulin resistance (IR). Methods: Thirty-six patients with obesity and 26 healthy volunteers were included in this cross-sectional study. The choroidal thickness was measured with enhanced depth imaging optical coherence tomography (EDI-OCT) at the fovea and at positions 500 μm, 1000 μm, 1500 μm nasal and temporal to the fovea. The choroidal thickness measurements of the groups were compared and the correlation between the homeostasis model assessment of insulin resistance (HOMA-IR) and choroidal thickness values was evaluated. Results: The average choroidal thickness in the obese group was significantly lower than that of controls at locations 1000 μm (303.31±58.52 vs. 340.58±69.47, p=0.026) and 1500 μm (284.14±65.06 vs. 336.85±71.37, p=0.004) temporal to the fovea. A subgroup analysis depending on the presence of IR revealed that the choroidal thickness measurements at all positions were thinner in obese children without IR compared to children with IR and healthy controls. This thinning reached a statistical significance at locations 500 μm temporal, 1000 μm temporal and 1500 μm temporal to the fovea (p=0.03, p=0.009 and p=0.006; respectively). There was a moderate correlation between the choroidal thickness measurements and HOMA-IR values (r-values between 0.37 and 0.48; p<0.05). Conclusions: Our results suggest that obesity and IR may have an influence on the choroidal thickness in children. Longitudinal studies will clarify whether these choroidal changes are progressive and are a sign of microvascular dysfunction in childhood obesity.

Evaluation of Choroidal Vascular Changes in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

2015 ◽  
Vol 235 (2) ◽  
pp. 65-71 ◽  
Author(s):  
Ebru Esen ◽  
Selcuk Sizmaz ◽  
Turgay Demir ◽  
Meltem Demirkiran ◽  
Ilker Unal ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Depth Imaging ◽  
Subfoveal Choroidal Thickness ◽  
Significant Difference ◽  
Imaging Optical Coherence Tomography ◽  
Thickness Measurements

Objective: To evaluate the choroidal thickness in patients with multiple sclerosis (MS) using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: In this observational comparative study, 68 eyes of 34 MS patients and 60 eyes of 30 healthy subjects were evaluated. All participants underwent complete ophthalmologic examination and OCT scanning. Choroidal thickness measurements were performed at seven points. Results: The mean subfoveal choroidal thickness was reduced significantly in MS patients (310.71 ± 61.85 μm) versus healthy controls (364.85 ± 41.81 μm) (p < 0.001). The difference was also significant at all six measurement points (p < 0.001 for all). Choroidal thickness measurements revealed no significant difference between MS eyes with a prior optic neuritis (ON) history (MS ON) and those without ON history (MS non-ON). Subfoveal choroidal thickness did not correlate with retinal nerve fiber layer and Expanded Disability Status Scale score, but reduced choroidal thickness was associated with longer disease duration (r = -0.28, p = 0.019) in MS patients. Conclusion: In MS patients, choroidal structural changes occur both in MS ON and MS non-ON eyes. The decreased choroidal thickness might provide evidence to support a potential role of vascular dysregulation in the pathophysiology of MS.

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