Cutaneous involvement by plasma cell myeloma with aberrant CD4 expression

2021 ◽  
Author(s):  
Philippa Li ◽  
Gauri Panse ◽  
Saurabh Singh ◽  
Stephen J. Krivda ◽  
Jennifer M. McNiff
Keyword(s):  
Plasma Cell ◽  
Plasma Cell Myeloma ◽  
Cutaneous Involvement

Cutaneous Involvement in Plasma Cell Myeloma

2020 ◽  
Vol 155 (1) ◽  
pp. 106-116
Author(s):  
Gauri Panse ◽  
Antonio Subtil ◽  
Jennifer M McNiff ◽  
Earl J Glusac ◽  
Christine J Ko ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Plasma Cell ◽  
Squamous Cell ◽  
Bone Marrow Involvement ◽  
Amyloid Deposition ◽  
Plasma Cell Myeloma ◽  
Older Individuals ◽  
Cutaneous Involvement

Abstract Objectives Plasma cell myeloma (PCM) involving skin is rare and occurs in 1% to 4% of patients with PCM. We evaluated the clinicopathologic features, cytogenetic findings and clinical follow-up in a series of PCM cases with cutaneous involvement. Methods Cases of PCM with cutaneous involvement were retrospectively reviewed with clinical data. Results Skin involvement in PCM occurred in older individuals (mean, 75 years) and was more frequent in men (7/10 patients). All cases showed bone marrow involvement preceding the cutaneous lesions. Histopathologically, the infiltrate was plasmacytic (n = 5) or primitive or plasmablastic (n = 4), and 1 case showed predominantly lymphoplasmacytic features with cyclin D1 immunoreactivity and CCND1 gene rearrangement. Concurrent amyloid deposition was seen in one biopsy, and another case demonstrated coexisting squamous cell carcinoma. The most common immunophenotype was CD138+, CD20–, and CD56+ with light chain restriction. Cytogenetic analysis (available for 7 cases) showed multiple hyperdiploid abnormalities. Follow-up was available for 8 cases (mean, 42 months; range, 11-156 months) and showed short-term disease-related death in 7 of 8 patients. Conclusions Cutaneous involvement in PCM demonstrates a diverse cytomorphologic spectrum with plasmacytic, plasmablastic, or lymphoplasmacytic features and may show concurrent amyloid deposition or neoplasms such as squamous cell carcinoma. Cutaneous involvement typically occurs late in the course of the disease and likely portends poor outcome.

scholarly journals Limitations of VS38c labeling in the detection of plasma cell myeloma by flow cytometry

2021 ◽  
Author(s):  
Ágnes Czeti ◽  
Gábor Szalóki ◽  
Gergely Varga ◽  
Virág Réka Szita ◽  
Zsolt István Komlósi ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Plasma Cell ◽  
Plasma Cell Myeloma

Plasma cell myeloma with histiocyte-like morphology

2017 ◽  
Vol 106 (3) ◽  
pp. 307-309
Author(s):  
Jianfeng Zhu ◽  
Baishen Pan ◽  
Jiamei Yao ◽  
Wei Guo
Keyword(s):  
Plasma Cell ◽  
Plasma Cell Myeloma

Anaplastic plasma cell myeloma and immunoblastic lymphoma

1984 ◽  
Vol 76 (5) ◽  
pp. 861-867 ◽  
Author(s):  
William R. Strand ◽  
Peter M. Banks ◽  
Robert A. Kyle
Keyword(s):  
Plasma Cell ◽  
Plasma Cell Myeloma ◽  
Immunoblastic Lymphoma

Plasma Cell Myeloma Associated with Epstein-Barr Virus Infection in an 11-Year-Old Girl

2012 ◽  
Vol 15 (4) ◽  
pp. 339-342 ◽  
Author(s):  
Karla Gisela Garcéa-Álvarez ◽  
Roberto Garibaldi-Covarrubias ◽  
Maréa Rosa Flores-Márquez ◽  
Carlos Ortiz-Hidalgo
Keyword(s):  
Virus Infection ◽  
Plasma Cell ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Plasma Cell Myeloma ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

An Unusual Case of Aggressive Systemic Mastocytosis With Associated Refractory Plasma Cell Myeloma

2012 ◽  
Vol 12 (6) ◽  
pp. 459-462 ◽  
Author(s):  
Preetesh Jain ◽  
Srdan Verstovsek ◽  
Robert Z. Orlowski ◽  
Ernie Yap ◽  
Hesham M. Amin
Keyword(s):  
Plasma Cell ◽  
Unusual Case ◽  
Systemic Mastocytosis ◽  
Plasma Cell Myeloma

Intermittent Melphalan and Prednisolone Therapy in Plasma Cell Myeloma

2009 ◽  
Vol 202 (1-6) ◽  
pp. 5-10 ◽  
Author(s):  
H. Mellstedt ◽  
M. Björkholm ◽  
G. Holm
Keyword(s):  
Plasma Cell ◽  
Plasma Cell Myeloma ◽  
Prednisolone Therapy

Genetic profile of primary plasma cell leukemia in Korea: comparison with plasma cell myeloma

2021 ◽  
pp. 1-10
Author(s):  
Youngeun Lee ◽  
Jiwon Yun ◽  
Dajeong Jeong ◽  
Sohee Ryu ◽  
Seok Ryun Kwon ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Plasma Cell Leukemia ◽  
Genetic Profile ◽  
Plasma Cell Myeloma ◽  
Cell Leukemia ◽  
Primary Plasma Cell Leukemia
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