Development of drug‐induced psoriasiform alopecia in a pediatric patient on ustekinumab

2021 ◽  
Author(s):  
Maria Mihailescu ◽  
Thomas Cibull ◽  
Joel Joyce
Keyword(s):  
Pediatric Patient ◽  
Drug Induced

A Rare Case of Levetiracetam and Drug‐Induced Idiopathic Aseptic Meningitis in a Pediatric Patient

2018 ◽  
Vol 39 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Danielle McDonald ◽  
Richard Sultan ◽  
Anusha Viswanathan ◽  
Anita Siu
Keyword(s):  
Pediatric Patient ◽  
Aseptic Meningitis ◽  
Rare Case ◽  
Drug Induced

Drug Induced Lung Disease Associated with Ustekinumab in a Pediatric Patient with Crohn's Disease

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Elana B. Mitchel ◽  
Adam Paul ◽  
Alexander El-Ali ◽  
Pi-Yu Cheng ◽  
Lindsey G. Albenberg
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Lung Disease ◽  
Pediatric Patient ◽  
Drug Induced

Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma

Transfusion ◽  
2014 ◽  
Vol 54 (11) ◽  
pp. 2901-2905 ◽  
Author(s):  
Marisol Betensky ◽  
Char Witmer ◽  
Michael J. Fisher ◽  
Sandra Nance ◽  
Mitchell J. Weiss ◽  
...  
Keyword(s):  
Pediatric Patient ◽  
Hemolytic Anemia ◽  
Optic Pathway Glioma ◽  
Optic Pathway ◽  
Drug Induced ◽  
Immune Hemolytic Anemia

scholarly journals Antibiotic hypersensitivity in CF: Drug-induced life-threatening hemolytic anemia in a pediatric patient

2010 ◽  
Vol 9 (6) ◽  
pp. 433-438 ◽  
Author(s):  
Alma Chavez ◽  
Amir Mian ◽  
Amy M. Scurlock ◽  
Douglas Blackall ◽  
Gulnur Com
Keyword(s):  
Pediatric Patient ◽  
Hemolytic Anemia ◽  
Drug Induced ◽  
Life Threatening

Tu1009 Assessing the Utility of Adult Drug Induced Liver Injury Criteria in the Pediatric Patient: A Pilot Analysis

2015 ◽  
Vol 148 (4) ◽  
pp. S-1083
Author(s):  
Kathleen M. Gura ◽  
Andrew E. Mulberg ◽  
Paul Mitchell ◽  
John Yap ◽  
Clara Kim ◽  
...  
Keyword(s):  
Liver Injury ◽  
Pediatric Patient ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Injury Criteria

Drug-induced granulomatous interstitial nephritis in a pediatric patient

2007 ◽  
Vol 22 (2) ◽  
pp. 306-309 ◽  
Author(s):  
James E. Tong ◽  
David N. Howell ◽  
John W. Foreman
Keyword(s):  
Pediatric Patient ◽  
Interstitial Nephritis ◽  
Drug Induced ◽  
Granulomatous Interstitial Nephritis

Vancomycin-Induced Neutropenia during Treatment of Endocarditis in a Pediatric Patient

1994 ◽  
Vol 28 (6) ◽  
pp. 723-726 ◽  
Author(s):  
Y. Todd Shinohara ◽  
James Colbert
Keyword(s):  
Pediatric Patient ◽  
Case Reports ◽  
Term Therapy ◽  
Vancomycin Therapy ◽  
Drug Induced ◽  
Case Summary ◽  
Drug Concentrations ◽  
Long Term Therapy ◽  
Possible Cause

OBJECTIVE: To report a case of reversible vancomycin-associated neutropenia occurring during long-term therapy with vancomycin using weight and age-adjusted dosing. CASE SUMMARY: A 2-year-old boy was started on vancomycin therapy for presumed endocarditis resulting from his ventriculoseptal defect. After 18 days of treatment, neutropenia with an absolute neutrophil count (ANC) of 990 × 106 cells/L was noted. The neutropenia progressed over the next 3 days and reached a nadir concentration of 459 × 106 cells/L. Vancomycin therapy was discontinued after 17 days (antibiotic day 20). A rise in the ANC occurred within 2 days of discontinuation. An improved ANC of 1672 × 106 cells/L occurred within 5 days. Vancomycin serum concentrations remained within an acceptable range: a peak of 30 μg/mL and a trough of 9 μg/mL. DISCUSSION: Case reports in the literature of vancomycin-associated neutropenia in adults were briefly reviewed and compared. The onset and resolution and mechanism of vancomycin-induced neutropenia were studied. The potential relationship between vancomycin, weight-, and age-adjusted dosing and the occurrence of neutropenia in our pediatric patient was postulated. CONCLUSIONS: Vancomycin is identified as a possible cause of drug-induced neutropenia. More data are needed that clearly indicate vancomycin as the offending agent in children. The vancomycin-induced neutropenia is believed to be immunologically based and independent of drug concentrations.

Drug-Induced Pancreatitis in a Pediatric Patient Following Acetaminophen Overdose

Pancreas ◽  
2020 ◽  
Vol 49 (5) ◽  
pp. e45-e46 ◽  
Author(s):  
Chinenye R. Dike ◽  
Oriana G. Vanegas Calderon ◽  
Warren Bishop ◽  
Aliye Uc
Keyword(s):  
Pediatric Patient ◽  
Drug Induced ◽  
Acetaminophen Overdose

scholarly journals IgG subclass staining in renal biopsy specimen in a pediatric patient with drug induced tubulointerstitial nephritis

2018 ◽  
Vol 31 (2) ◽  
pp. 160-166
Author(s):  
Ryuko Amo ◽  
Takehisa Yamamoto ◽  
Eri Kijima ◽  
Mihoko Sakurai ◽  
Chieko Yamada ◽  
...  
Keyword(s):  
Renal Biopsy ◽  
Pediatric Patient ◽  
Biopsy Specimen ◽  
Tubulointerstitial Nephritis ◽  
Igg Subclass ◽  
Drug Induced ◽  
Renal Biopsy Specimen

Early Development of Drug-Induced Hepatic Necrosis

1971 ◽  
Vol 29 ◽  
pp. 576-577
Author(s):  
F. G. Zaki ◽  
E. Detzi ◽  
C. H. Keysser
Keyword(s):  
Early Development ◽  
Hepatic Necrosis ◽  
Screening Tests ◽  
Dense Matrix ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Drug Induced ◽  
Hepatocellular Damage ◽  
Sprague Dawley Rats ◽  
Microscopic Studies

This study represents the first in a series of investigations carried out to elucidate the mechanism(s) of early hepatocellular damage induced by drugs and other related compounds. During screening tests of CNS-active compounds in rats, it has been found that daily oral administration of one of these compounds at a dose level of 40 mg. per kg. of body weight induced diffuse massive hepatic necrosis within 7 weeks in Charles River Sprague Dawley rats of both sexes. Partial hepatectomy enhanced the development of this peculiar type of necrosis (3 weeks instead of 7) while treatment with phenobarbital prior to the administration of the drug delayed the appearance of necrosis but did not reduce its severity.Electron microscopic studies revealed that early development of this liver injury (2 days after the administration of the drug) appeared in the form of small dark osmiophilic vesicles located around the bile canaliculi of all hepatocytes (Fig. 1). These structures differed from the regular microbodies or the pericanalicular multivesicular bodies. They first appeared regularly rounded with electron dense matrix bound with a single membrane. After one week on the drug, these vesicles appeared vacuolated and resembled autophagosomes which soon developed whorls of concentric lamellae or cisterns characteristic of lysosomes (Fig. 2). These lysosomes were found, later on, scattered all over the hepatocytes.

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