PRAME Immunohistochemistry is Useful in the Evaluation of Conjunctival Melanomas, Nevi, and Primary Acquired Melanosis

2021 ◽  
Author(s):  
Robert E. LeBlanc ◽  
Donald M. Miller ◽  
Michael E. Zegans
Keyword(s):  
Primary Acquired Melanosis

Primary acquired melanosis (PAM) without atypia/WHO low-grade conjunctival melanocytic intraepithelial lesion over areas of oculodermal melanocytosis

2020 ◽  
Vol 13 (10) ◽  
pp. e236741
Author(s):  
Bashar M Bata ◽  
Sachin M Salvi ◽  
Hardeep Singh Mudhar
Keyword(s):  
Bulbar Conjunctiva ◽  
Low Grade ◽  
Primary Acquired Melanosis ◽  
Conjunctival Biopsy ◽  
History Of ◽  
Intraepithelial Lesion ◽  
The Relationship ◽  
Oculodermal Melanocytosis ◽  
Substantia Propria ◽  
New Onset

An elderly white man with a history of left oculodermal melanocytosis presented with new onset brown pigmentation of the left bulbar and inferior tarsal conjunctiva. The bulbar conjunctival pigmentation was at the level of the conjunctival epithelium and was overlying areas of typical slate-grey scleral pigmentation characteristic of oculodermal melanocytosis. Both areas of new pigmentation were biopsied. The bulbar conjunctiva revealed primary acquired melanosis (PAM) without atypia with increased melanin production and the tarsal conjunctival biopsy showed PAM without atypia sine pigmentio overlying areas of substantia propria spindle-shaped heavily pigmented melanocytes of oculodermal melanocytosis. The case report examines the relationship between the epithelial and substantia propria melanocytes and correlates the findings with what is known about this association from the dermatopathology literature.

Animal Model of Conjunctival Primary Acquired Melanosis

Ophthalmology ◽  
1989 ◽  
Vol 96 (7) ◽  
pp. 1006-1013 ◽  
Author(s):  
Robert Folberg ◽  
Jeffrey Baron ◽  
Raymond D. Reeves ◽  
Reggie H. Stevens ◽  
Lisa D. Bogh
Keyword(s):  
Animal Model ◽  
Primary Acquired Melanosis

scholarly journals Primary acquired melanosis: A unique presentation

2020 ◽  
Vol 6 (3) ◽  
pp. 223-225
Author(s):  
Gunjan Chadha ◽  
Vandana Sharma ◽  
Anchit Wapa ◽  
Joginder Pal Chugh ◽  
Urmil Chawla
Keyword(s):  
Primary Acquired Melanosis

Conjunctival Primary Acquired Melanosis

2012 ◽  
pp. 145-150
Author(s):  
Jerome C. Ramos-Esteban ◽  
Arun D. Singh ◽  
Jill R. Wells ◽  
Hans E. Grossniklaus
Keyword(s):  
Primary Acquired Melanosis

scholarly journals A rare case of conjunctival malignant melanoma with orbital invasion

2019 ◽  
Vol 11 (1) ◽  
pp. 77-81
Author(s):  
Yogita Rajbhandari ◽  
Sharad Gupta ◽  
Reena Yadav ◽  
Ashma Manandhar ◽  
Aye Myat Mon ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
De Novo ◽  
The Elderly ◽  
Palpebral Conjunctiva ◽  
Pigmented Lesion ◽  
Primary Acquired Melanosis ◽  
Chief Complaints ◽  
Wooden Stick ◽  
Metastasis Rate ◽  
Orbital Invasion

Background: Conjunctival malignant melanoma is a rare ocular malignancy most commonly affecting mostly the elderly population. It is a pigmented lesion which canarise from primary acquired melanosis, de novo or from preexisting nevus. Case: A 63 year old male presented with a chief complaints rapidly increasing mass in the left eye for two months following trauma with a wooden stick. He had preexisting nevus in the same eye. His best corrected visual acuity was 6/12 in right eye and 1/60 left eye respectively. Slit lamp biomicroscopy examination showed 4 cm x 4 cm pigmented mass in the nasal bulbar and inferior palpebral conjunctiva causing mechanical ectropion of the lower lid with keratinization of palpebral conjunctiva. Incisionalbiopsy of conjunctiva showed malignant melanoma. On computed tomography, there was expansion of bony orbit. Considering all the findings, exenteration of the left orbitwas done. Histopathological report of exenterated mass was suggestive of malignantmelanoma of conjunctiva. Conclusion: Conjunctival melanoma is a rare malignant tumor of eye which has high metastasis rate and the treatment option is surgery with adjuvant therapy.

Immunostaining of the Estrogen Receptor in Conjunctival Primary Acquired Melanosis

1999 ◽  
Vol 31 (3) ◽  
pp. 210-212 ◽  
Author(s):  
Itay Chowers ◽  
Nelly Livni ◽  
Joseph Frucht-Pery ◽  
Jacob Pe’er
Keyword(s):  
Estrogen Receptor ◽  
Primary Acquired Melanosis
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