Epigenetic marker expression is of limited diagnostic utility in spitzoid melanocytic neoplasms

2020 ◽  
Vol 47 (12) ◽  
pp. 1228-1232
Author(s):  
Stephanie Yagi ◽  
Bonnie L. Balzer ◽  
David P. Frishberg ◽  
Wonwoo Shon
Keyword(s):  
Diagnostic Utility ◽  
Epigenetic Marker ◽  
Marker Expression

1798: Expression and Diagnostic Utility of P63 and Alpha-Methyl-Coa-Racemase (P504S) Cocktail in Ambiguous Lesion of the Prostate

2004 ◽  
Vol 171 (4S) ◽  
pp. 475-475
Author(s):  
Vincent Molinie ◽  
Jean-Marie Herve ◽  
Mathilde Sibony ◽  
Gaelle Fromont ◽  
Annick Vieillefond ◽  
...  
Keyword(s):  
Diagnostic Utility

Tissue plasminogen activator as a novel diagnostic aid in acute pulmonary embolism

VASA ◽  
2014 ◽  
Vol 43 (6) ◽  
pp. 450-458 ◽  
Author(s):  
Julio Flores ◽  
Ángel García-Avello ◽  
Esther Alonso ◽  
Antonio Ruíz ◽  
Olga Navarrete ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Negative Predictive Value ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Predictive Value ◽  
Acute Pulmonary Embolism ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diagnostic Utility ◽  
Tissue Plasminogen ◽  
D Dimer

Background: We evaluated the diagnostic efficacy of tissue plasminogen activator (tPA), using an enzyme-linked immunosorbent assay (ELISA) and compared it with an ELISA D-dimer (VIDAS D-dimer) in acute pulmonary embolism (PE). Patients and methods: We studied 127 consecutive outpatients with clinically suspected PE. The diagnosis of PE was based on a clinical probability pretest for PE and a strict protocol of imaging studies. A plasma sample to measure the levels of tPA and D-dimer was obtained at enrollment. Diagnostic accuracy for tPA and D-dimer was determined by the area under the receiver operating characteristic (ROC) curve. Sensitivity, specificity, predictive values, and the diagnostic utility of tPA with a cutoff of 8.5 ng/mL and D-dimer with a cutoff of 500 ng/mL, were calculated for PE diagnosis. Results: PE was confirmed in 41 patients (32 %). Areas under ROC curves were 0.86 for D-dimer and 0.71 for tPA. The sensitivity/negative predictive value for D-dimer using a cutoff of 500 ng/mL, and tPA using a cutoff of 8.5 ng/mL, were 95 % (95 % CI, 88–100 %)/95 % (95 % CI, 88–100 %) and 95 % (95 % CI, 88–100 %)/94 %), respectively. The diagnostic utility to exclude PE was 28.3 % (95 % CI, 21–37 %) for D-dimer and 24.4 % (95 % CI, 17–33 %) for tPA. Conclusions: The tPA with a cutoff of 8.5 ng/mL has a high sensitivity and negative predictive value for exclusion of PE, similar to those observed for the VIDAS D-dimer with a cutoff of 500 ng/mL, although the diagnostic utility was slightly higher for the D-dimer.

Diagnostic Utility of the A1 and A2 Criteria

2009 ◽  
Author(s):  
Steven Lancaster ◽  
Stephen Melka ◽  
Benjamin Rodriguez
Keyword(s):  
Diagnostic Utility

THE DIAGNOSTIC UTILITY OF INPATIENT VIDEO-EEG MONITORING IN PEDIATRICS

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
A Abdelmoity ◽  
W Graf ◽  
H Tsoi ◽  
M Wise
Keyword(s):  
Diagnostic Utility ◽  
Eeg Monitoring ◽  
Video Eeg
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