Pilomatricoma with florid osseous metaplasia: A common tumor with rare histopathological finding

2020 ◽  
Author(s):  
Sushma Bharti ◽  
Aasma Nalwa ◽  
Madhubala Rajendran ◽  
Meenakshi Rao ◽  
Poonam Abhay Elhence
Keyword(s):  
Histopathological Finding ◽  
Osseous Metaplasia

Incidentally Discovered Osseous Metaplasia Within High-grade Urothelial Carcinoma of the Bladder

Urology ◽  
2012 ◽  
Vol 79 (4) ◽  
pp. e59-e60 ◽  
Author(s):  
Anne G. Dudley ◽  
Jeffrey J. Tomaszewski ◽  
Amber H. Hughes ◽  
Benjamin J. Davies
Keyword(s):  
Urothelial Carcinoma ◽  
Osseous Metaplasia ◽  
High Grade ◽  
Carcinoma Of The Bladder

scholarly journals Imaging of endometrial osseous metaplasia—an uncommon but treatable cause of infertility

2020 ◽  
Vol 25 (1) ◽  
Author(s):  
Abdul Haseeb Wani ◽  
Arshed Hussain Parry ◽  
Imza Feroz ◽  
Majid Jehangir ◽  
Masarat Rashid
Keyword(s):  
Inflammatory Cells ◽  
Osseous Metaplasia ◽  
Dystrophic Calcification ◽  
Non Invasive ◽  
Dilatation And Curettage ◽  
Clinical Scenarios ◽  
Uncommon Condition ◽  
Urinary Tuberculosis ◽  
Hypointense Signal ◽  
Metaplastic Ossification

Abstract Background Endometrial osseous metaplasia (EOM) is an uncommon condition characterised by metaplastic transformation of endometrial tissue into osteoblasts (mature or immature bone in the endometrium). Etiopathogenesis of EOM is explained by multiple putative mechanisms like dystrophic calcification, metaplastic ossification, retained foetal bones after abortions and genito-urinary tuberculosis. EOM has varied clinical presentation ranging from patient being asymptomatic to secondary infertility. Although hysteroscopy is the gold standard for its diagnosis and treatment, non-invasive imaging comprising chiefly of ultrasonography (USG) is increasingly becoming the mainstay of diagnosis. We aim to present the imaging findings in EOM to acquaint radiologists and gynaecologists with this condition to avert misdiagnosis of this uncommon yet treatable cause of infertility. Results Mean age of patients was 31.4 ± 5.4 (S.D) years. USG revealed linear or tubular densely echogenic endometrium with posterior acoustic shadowing in all the 14 patients. MRI in 3 patients revealed diffuse or patchy areas of T1W and T2W hypointense signal intensity with unilateral (n = 2) and bilateral (n = 1) ovarian cysts. One patient who underwent CT scan revealed dense endometrial calcification. Histopathologic examination (HPE) revealed lamellar (n = 6) or trabecular (n = 4) bone within endometrium (EOM) and inflammatory cells with calcification in four patients (calcific endometritis). Twelve patients conceived after dilatation and curettage within 15 months. Conclusion Familiarity with the imaging appearances of EOM is indispensable to clinch this diagnosis and avert misdiagnosis of this rare but potentially treatable cause of infertility. USG is usually sufficient for diagnosis. MRI and CT are only supplementary tools in difficult clinical scenarios.

scholarly journals GASTRIC CARCINOMA WITH OSSEOUS METAPLASIA IN A DOG

2012 ◽  
Vol 17 (3) ◽  
Author(s):  
Irina Ferraz Amorim ◽  
Celia Lopes ◽  
Rui M Gil da Costa ◽  
Augusto MR Faustino ◽  
Fatima Gartner ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Epithelial Cells ◽  
Gastric Carcinoma ◽  
Heterotopic Ossification ◽  
Bone Tissue ◽  
Exploratory Laparotomy ◽  
Osseous Metaplasia ◽  
Mucin Production ◽  
Positive Immunostaining ◽  
Neoplastic Epithelial Cells

This report describes an unprecedented case of a gastric carcinoma with osseous metaplasia in a 8-year-old male standard poodle. An exploratory laparotomy revealed a firm yellowish nodular mass in the pyloric region. The lesion was surgically removed and submitted for current histological examination. Immunohistochemistry was performed employing monoclonal antibodies for pan-cytokeratin, vimentin, smooth muscular a-actin and BMP-2/4. The mass consisted in neoplastic proliferation of epithelial cells, arranged in a tubular or acinar pattern and supported by scirrhous stroma, with mucin production and multiple foci of heterotopic ossification. Neoplastic epithelial cells showed strong positive immunostaining for AE1/AE3 and BMP-2/4, although they were negative for both vimentin and a-actin. Histopathological findings suggested that the bone tissue may be primarily originated from neoplastic epithelial cells which directly circumscribe the osseous metaplasia foci.

Lipoma of submandibular space with osseous metaplasia

1973 ◽  
Vol 35 (5) ◽  
pp. 611-615 ◽  
Author(s):  
Nicolae Dutescu ◽  
Leonida Georgescu ◽  
Mihai Hary
Keyword(s):  
Osseous Metaplasia ◽  
Submandibular Space

Osseous metaplasia of the endometrium: a multicenter retrospective study

2021 ◽  
Author(s):  
Simone Garzon ◽  
Antonio Simone Laganà ◽  
Jose Carugno ◽  
Enric Cayuela Font ◽  
Josè Jimenez ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Osseous Metaplasia

scholarly journals Osseous Metaplasia of the Vaginal Vault: A Case Report

2017 ◽  
Vol 68 (6) ◽  
pp. 502-504
Author(s):  
Sajna V. M. Kutty ◽  
K. P. Kavitha ◽  
Nazer Thalamkandathil
Keyword(s):  
Case Report ◽  
Vaginal Vault ◽  
Osseous Metaplasia

Stromal osseous metaplasia in a low-grade ovarian adenocarcinoma

2005 ◽  
Vol 99 (1) ◽  
pp. 222-224 ◽  
Author(s):  
P. Mukonoweshuro ◽  
A. Oriowolo
Keyword(s):  
Osseous Metaplasia ◽  
Low Grade ◽  
Ovarian Adenocarcinoma

Abstract W P73: Inside Intramural Thrombus Formation with Inflammatory Reactions Is Relevant to the Rupture of Cerebral Aneurysms

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Yusuke Shimoda ◽  
Naoki Nakayama ◽  
Masaaki Hokari ◽  
Takeo Abumiya ◽  
Hideo Shichinohe ◽  
...  
Keyword(s):  
Thrombus Formation ◽  
Cerebral Aneurysms ◽  
Histopathological Finding ◽  
Internal Elastic Lamina ◽  
Electron Microscopic ◽  
Inflammatory Reactions ◽  
Aneurysmal Wall ◽  
The Common ◽  
Collagen Layer ◽  
Elastic Lamina

Background and Purpose: Although recent researches on cerebral aneurysms (CAs) have been performed with the hydrodynamic or the molecular biological technique, the mechanisms of rupture are not fully understood. The aim of this study is to assess the mechanism by a comparison between ruptured and un-ruptured CAs with histopathological and electron-microscopic analysis. Methods: We analyzed 33 CAs (24 ruptured, 9 un-ruptured) collected surgically after neck clipping. As for the ruptured CAs, we operated them within 24 hours from the onset. HE staining, Elastica Masson staining, PTAH staining, and CD68 immunohistochemical staining were performed with paraffin sections. Morphological analysis with Scanning Electron Microscopy (SEM) was performed with 6 CAs (3 ruptured, 3 un-ruptured). Results: The common histopathological finding in both ruptured and un-ruptured CAs was that the aneurysmal wall consisted mostly of thick collagen layer without normal internal elastic lamina and media. The characteristic histopathological finding in ruptured CAs was inside intramural thrombus formation with infiltration of CD68 positive cells at the rupture point. The common SEM finding in both ruptured and un-ruptured CAs was the denudation of endothelial cells and the exposure of a subendothelial amorphous or a fibrous surface. The characteristic SEM finding in ruptured CAs was the cluster formation of thick fibrin fibers with incorporation of macrophages and platelets. Conclusions: While the endothelial denudation, the disappearance of internal elastic lamina and media, and the predominance of collagen layer in the aneurysmal wall were common in both ruptured and un-ruptured CAs, inside intramural thrombus formation with inflammatory reactions was characteristic only in ruptured CAs. This result suggests that thrombo-inflammatory reactions in CAs may act as a trigger for ruptures.

Endometrial osseous metaplasia: an evolving cause of secondary infertility

2008 ◽  
Vol 90 (5) ◽  
pp. 2013.e9-2013.e11 ◽  
Author(s):  
Lutfu Sabri Onderoglu ◽  
Hakan Yarali ◽  
Murat Gultekin ◽  
Doruk Katlan
Keyword(s):  
Osseous Metaplasia ◽  
Secondary Infertility
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