Cutaneous spindled follicle center cell lymphoma with abundant mucin: A diagnostic pitfall

2019 ◽  
Vol 47 (4) ◽  
pp. 394-397 ◽  
Author(s):  
Lin Li ◽  
Jacquelyn Majerowski ◽  
Olayemi Sokumbi
Keyword(s):  
Cell Lymphoma ◽  
Diagnostic Pitfall ◽  
Center Cell

Cutaneous Follicle Center Cell Lymphoma

2009 ◽  
pp. 476-477
Author(s):  
Nils Peters ◽  
Martin Dichgans ◽  
Sankar Surendran ◽  
Josep M. Argilés ◽  
Francisco J. López-Soriano ◽  
...  
Keyword(s):  
Cell Lymphoma ◽  
Center Cell

scholarly journals Large noncleaved follicular center cell lymphoma clinical features in 53 patients

Cancer ◽  
1986 ◽  
Vol 57 (2) ◽  
pp. 288-297 ◽  
Author(s):  
Mary L. Stewart ◽  
Ira E. Felman ◽  
Peter W. Nichols ◽  
Annlia Pagnini-Hill ◽  
Robert J. Lukes ◽  
...  
Keyword(s):  
Clinical Features ◽  
Cell Lymphoma ◽  
Center Cell

Merkel cell carcinoma arising in association with cutaneous T‐cell lymphoma: A potential diagnostic pitfall

2019 ◽  
Vol 46 (3) ◽  
pp. 199-203
Author(s):  
Nicholas A. Zoumberos ◽  
Emily McMullen ◽  
Lisha Wang ◽  
Xiaoming Wang ◽  
Kelly L. Harms ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Merkel Cell ◽  
Diagnostic Pitfall

scholarly journals Malignant lymphoma of follicular center cell origin in humans. IV. Small transformed (noncleaved) cell lymphoma of the non-burkitt's type

Cancer ◽  
1983 ◽  
Vol 52 (7) ◽  
pp. 1196-1201 ◽  
Author(s):  
David L. Oviatt ◽  
John B. Cousar ◽  
John M. Flexner ◽  
Paul J. Kurtin ◽  
Robert D. Collins ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Cell Lymphoma ◽  
Center Cell

Nonimmunoglobulin Gene Hypermutation in Germinal Center B Cells

Blood ◽  
1999 ◽  
Vol 93 (7) ◽  
pp. 2167-2172 ◽  
Author(s):  
Huai-Zheng Peng ◽  
Ming-Qing Du ◽  
Athanasios Koulis ◽  
Antonella Aiello ◽  
Ahmet Dogan ◽  
...  
Keyword(s):  
B Cells ◽  
Germinal Center ◽  
Cell Lymphoma ◽  
Somatic Hypermutation ◽  
Mantle Zone ◽  
Germinal Center Reaction ◽  
Inherent Feature ◽  
Mantle Cell ◽  
Center Cell ◽  
Germinal Center B Cells

Somatic hypermutation is the most critical mechanism underlying the diversification of Ig genes. Although mutation occurs specifically in B cells during the germinal center reaction, it remains a matter of debate whether the mutation machinery also targets non-Ig genes. We have studied mutations in the 5′ noncoding region of the Bcl6 gene in different subtypes of lymphomas. We found frequent hypermutation in follicular lymphoma (25 of 59 = 42%) (germinal center cell origin) and mucosa-associated lymphoid tissue (MALT) lymphoma (19 of 45 = 42%) (postgerminal center), but only occasionally in mantle cell lymphoma (1 of 21 = 4.8%) (pregerminal center). Most mutations were outside the motifs potentially important for transcription, suggesting they were not important in lymphomagenesis but may, like Ig mutation, represent an inherent feature of the lymphoma precursor cells. Therefore, we investigated their normal cell counterparts microdissected from a reactive tonsil. Bcl6 mutation was found in 13 of 24 (54%) clones from the germinal centre but only in 1 of 24 (4%) clones from the naive B cells of the mantle zone. The frequency, distribution, and nature of these mutations were similar to those resulting from the Ig hypermutation process. The results show unequivocal evidence of non-Ig gene hypermutation in germinal center B cells and provide fresh insights into the process of hypermutation and lymphomagenesis.

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