Lipomatous metaplasia of superficial dermis

2015 ◽  
Vol 43 (2) ◽  
pp. 120-124 ◽  
Author(s):  
Paul B. Googe ◽  
W. James Tidwell ◽  
Andrew E. Rosenberg
Keyword(s):  
Superficial Dermis ◽  
Lipomatous Metaplasia

Band-like Lipomatous Metaplasia of the Superficial Dermis and Nonseptate Subcutaneous Tissue: A Rare Histopathological Phenomenon With Ultrasonographic Correlation

2019 ◽  
Vol 42 (7) ◽  
pp. 526-529
Author(s):  
Nataly Portilla ◽  
Mónica Quintana-Codina ◽  
Marta Olivé ◽  
Noelia Pérez-Muñoz ◽  
Montse Salleras ◽  
...  
Keyword(s):  
Subcutaneous Tissue ◽  
Superficial Dermis ◽  
Lipomatous Metaplasia

scholarly journals Clinical Relevance of Elastin in the Structure and Function of Skin

2021 ◽  
Author(s):  
Leslie Baumann ◽  
Eric F Bernstein ◽  
Anthony S Weiss ◽  
Damien Bates ◽  
Shannon Humphrey ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Relevance ◽  
Structural Integrity ◽  
Elastic Fiber ◽  
Subcutaneous Fat ◽  
Structure And Function ◽  
Fiber Formation ◽  
Elastic Fibers ◽  
Superficial Dermis ◽  
And Function

Abstract Elastin is the main component of elastic fibers, which provide stretch, recoil, and elasticity to the skin. Normal levels of elastic fiber production, organization, and integration with other cutaneous extracellular matrix proteins, proteoglycans, and glycosaminoglycans are integral to maintaining healthy skin structure, function, and youthful appearance. Although elastin has very low turnover, its production decreases after individuals reach maturity and it is susceptible to damage from many factors. With advancing age and exposure to environmental insults, elastic fibers degrade. This degradation contributes to the loss of the skin’s structural integrity; combined with subcutaneous fat loss, this results in looser, sagging skin, causing undesirable changes in appearance. The most dramatic changes occur in chronically sun-exposed skin, which displays sharply altered amounts and arrangements of cutaneous elastic fibers, decreased fine elastic fibers in the superficial dermis connecting to the epidermis, and replacement of the normal collagen-rich superficial dermis with abnormal clumps of solar elastosis material. Disruption of elastic fiber networks also leads to undesirable characteristics in wound healing, and the worsening structure and appearance of scars and stretch marks. Identifying ways to replenish elastin and elastic fibers should improve the skin’s appearance, texture, resiliency, and wound-healing capabilities. However, few therapies are capable of repairing elastic fibers or substantially reorganizing the elastin/microfibril network. This review describes the clinical relevance of elastin in the context of the structure and function of healthy and aging skin, wound healing, and scars and introduces new approaches being developed to target elastin production and elastic fiber formation.

A Case of Myxoid Adrenocortical Carcinoma With Extensive Lipomatous Metaplasia

2003 ◽  
Vol 127 (2) ◽  
pp. 227-230 ◽  
Author(s):  
Miki Izumi ◽  
Hiromi Serizawa ◽  
Keiichi Iwaya ◽  
Kazuhiro Takeda ◽  
Hironobu Sasano ◽  
...  
Keyword(s):  
Heart Failure ◽  
Adrenocortical Carcinoma ◽  
Adrenal Tumor ◽  
Carcinoma Cells ◽  
Peculiar Feature ◽  
Radiographic Examination ◽  
Rare Phenomenon ◽  
Cut Surface ◽  
Vacuolated Cytoplasm ◽  
Lipomatous Metaplasia

Abstract We report a combination of unusual myxoid change and extensive lipomatous metaplasia of an adrenocortical carcinoma. The patient was a 38-year-old man with hypertension and heart failure. Radiographic examination revealed the presence of a left adrenal tumor, and adrenalectomy was performed. The tumor weighed 380 g and appeared encapsulated. The cut surface was predominantly gelatinous. Histologically, the tumor was composed of atypical round cells with eosinophilic to vacuolated cytoplasm. The tumor was diagnosed as adrenocortical carcinoma. The stroma accumulated copious mucinous material. In addition, individual to nodular mature adipocytes were admixed throughout the tumor. The transition from carcinoma cells to mature adipocytes was recognized. Myxoid change is a very rare phenomenon in adrenocortical carcinoma, and only 10 similar cases have been reported to date. Lipomatous metaplasia is another peculiar feature of adrenocortical lesions that has been reported only in benign conditions. To our knowledge, this is the first reported case of adrenocortical carcinoma with lipomatous metaplasia.

scholarly journals Localized cutaneous argyria: a new observation

2021 ◽  
Vol 12 (1) ◽  
pp. 30-32
Author(s):  
Selma El Kadiri ◽  
Hanane Baybay
Keyword(s):  
Cell Layer ◽  
Sweat Glands ◽  
Elastic Fibers ◽  
Dermatological Examination ◽  
Entire Duration ◽  
Nickel Copper ◽  
Iron Nickel ◽  
Superficial Dermis ◽  
Eccrine Sweat Glands ◽  
Switching Treatment

A 27-year-old female, a radiotherapy technician, was referred to our consultation with a localized gray pigmentation of the perinasal area. The condition had been asymptomatic for its entire duration of 2 years. A dermatological examination found a localized bluish-gray pigmentation in the perinasal area. Dermoscopy revealed an annular bluish-gray patch. Her occupation involved the manufacture and micromanipulation of machines, which required handling pure iron, nickel, copper, and silver with bare hands. She also reported a tic of flaring the nose. A skin biopsy was performed and histology revealed deposits of fine granules in the basal cell layer of eccrine sweat glands and along the elastic fibers of the superficial dermis, conforming with the diagnosis of argyria. The patient was given laser Q-switching treatment and showed a measurable improvement. This case studies a currently rare dermatological curiosity. Argyria is a disease caused by chronic absorption of silver-rich materials. This is the first description of argyria following the manipulation of radiopaque caches with a tic of flaring the nose.

scholarly journals Incontinentia pigmenti: A propósito de un caso.

2013 ◽  
Vol 6 (3) ◽  
Author(s):  
Tori Tori Carlos ◽  
Enriqueta Villar De Cipriani ◽  
Javier Arias Stella ◽  
Carmen Avalos
Keyword(s):  
Skin Eruption ◽  
American Indians ◽  
Basal Layer ◽  
Signs And Symptoms ◽  
Black Children ◽  
Incontinentia Pigmenti ◽  
South American ◽  
North Central ◽  
Central Nervous Systems ◽  
Superficial Dermis

Incontinentia Pigmenti is a rare X-linked multisystem neuroectodermic disorder with signs and symptoms related mainly to the dermatologic, dental, ocular and central nervous systems, and characterized by death in the majority of male embryos. Affected children do not appear sick, in spite of the skin eruption, the peripheral leucocytosis and marked eosinophilia. Most of the cases are reported in caucasians, although there are description in black children, orientals, north central and south american Indians, and in our mestizos. The name of Incontinentia Pigmenti describes the incontinence of the melanin pigment from the basal layer of the epidemermis into the superficial dermis.

The structure and distribution of proteochondroitin sulphate during the formation of chick embryo feather germs

Development ◽  
1987 ◽  
Vol 100 (3) ◽  
pp. 501-512 ◽  
Author(s):  
KUNIO KITAMURA
Keyword(s):  
Molecular Weight ◽  
Chick Embryo ◽  
Basement Membrane ◽  
The Other ◽  
Dorsal Skin ◽  
Superficial Dermis ◽  
Dermal Cells ◽  
Asymmetrically Distributed ◽  
Slow Turnover ◽  
Feather Buds

The dorsal skin of the chick embryo, in which feather germ forms, was found to synthesize two proteochondroitin sulphates, PCS-I and PCS-II and a proteoheparan sulphate, PHS. A monoclonal antibody (I3B9) was prepared against PCS-I, a higher molecular weight proteochondroitin sulphate. Distribution of PCS-I was immunohistochemically studied using I3B9. PCS-I was found in the epidermis, basement membrane and superficial dermis prior to formation of feather rudiments. As the feather rudiments formed, PCS-I was noted in a condensed area of dermal cells and in the basement membrane, while PCS-I decreased remarkably in the epidermal placode. The formation of feather buds resulted in a decrease in PCS-I in the region of dermal condensation and the basement membrane situated above this region. PCS-I was asymmetrically distributed in the feather filaments. The turnover of proteochondroitin sulphate was studied using autoradiography of [35S]sulphate. Proteochondroitin sulphate in the basement membrane and condensed dermis of the feather rudiments showed very slow turnover. On the other hand, the outgrowth of feather buds caused rapid turnover of proteochondroitin sulphate in the region of dermal condensation and basement membrane situated above this region. The mechanism for the uneven distribution of PCS-I during feather germ formation is discussed.

scholarly journals The Differential Diagnosis of Hypopigmented Mycosis Fungoides and Vitiligo With Reflectance Confocal Microscopy: A Preliminary Study

2021 ◽  
Vol 7 ◽  
Author(s):  
Huaxu Liu ◽  
Leilei Wang ◽  
Yan Lin ◽  
Xiaofeng Shan ◽  
Min Gao
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Mycosis Fungoides ◽  
Early Stage ◽  
Reflectance Confocal Microscopy ◽  
Inflammatory Conditions ◽  
Dark Space ◽  
Superficial Dermis ◽  
Melanin Contents

Objective: To investigate the role of reflectance confocal microscopy (RCM) in the differential diagnosis of hypopigmented mycosis fungoides (HMF) and vitiligo.Methods: Cases with persistent hypopigmented patches, suspicious of early stage vitiligo, or HMF were imaged with RCM. The melanin contents and inflammatory conditions of the epidermis and superficial dermis of the lesions were compared with the same layers of the adjacent skin, and then, the imaged lesions were biopsied and analyzed by histology.Results: 15 cases were enrolled in this study, and based on the RCM findings, there was just slight or moderate reduction of melanin but no melanin absence in the basal cell layer of HMF lesions. The finding of monomorphous weakly refractile, oval to round cells on the basis of vesicle-like dark space was clearly elucidated in the epidermis of the lesions by RCM, which indicates the Pautrier's microabscesses on histopathology. Among those 15 cases, 13 cases were identified as HMF, and the other two cases were vitiligo, based on RCM findings, which were confirmed by histology analysis.Conclusions: The RCM findings correlated well with histology results in the screening of HMF, which indicates the RCM is an important tool in the early detection and differential diagnosis of HMF.

scholarly journals Topical steroid application can induce branched/reticular vessels in Bowen disease on the upper trunk

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Hiroyo Hashimoto ◽  
Yaei Togawa ◽  
Naoki Aoyagi ◽  
Ryoji Kurita ◽  
Rena Oguma ◽  
...  
Keyword(s):  
Medical Records ◽  
Topical Steroid ◽  
Topical Steroids ◽  
Steroid Use ◽  
Keratinocyte Proliferation ◽  
History Of ◽  
Superficial Dermis ◽  
Bowen Disease ◽  
Epidermal Atrophy ◽  
Chronic Eczema

We aimed to elucidate the dermoscopic vasculature of patients with Bowen Disease (BD) that was misdiagnosed as chronic eczema and had branched and/or reticular vessels after topical steroid application. The medical records of 19 patients with BD on the upper trunk were retrospectively reviewed for steroid use history, vascular structure observed in dermoscopy, and corresponding histological findings. Four patients treated with strong topical steroids showed remarkable branched and/or reticular vessels on dermoscopy. Histopathology showed partial epidermal atrophy with irregular thin elongation of the rete ridges, atypical keratinocyte proliferation in the epidermis, and vasodilation in the superficial dermis. We considered that vasodilation and partial epidermal atrophy may be induced by topical steroid application in BD-affected areas. In cases of suspected BD with reddish-brown plaque showing branched and/or reticulated vessels in dermoscopy, confirming a history of topical steroid use is helpful.

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