Prior knowledge of the clinical picture does not introduce bias in the histopathologic diagnosis of melanocytic skin lesions

2015 ◽  
Vol 42 (12) ◽  
pp. 953-958 ◽  
Author(s):  
Gerardo Ferrara ◽  
Giorgio Annessi ◽  
Zsolt Argenyi ◽  
Giuseppe Argenziano ◽  
Helmut Beltraminelli ◽  
...  
Keyword(s):  
Prior Knowledge ◽  
Clinical Picture ◽  
Skin Lesions ◽  
Histopathologic Diagnosis

scholarly journals Effects of Ex Vivo Skin Microbiopsy on Histopathologic Diagnosis in Melanocytic Skin Lesions

2013 ◽  
Vol 149 (9) ◽  
pp. 1107 ◽  
Author(s):  
Parastoo Banan ◽  
Lynlee L. Lin ◽  
Duncan Lambie ◽  
Tarl Prow ◽  
H. Peter Soyer
Keyword(s):  
Ex Vivo ◽  
Skin Lesions ◽  
Histopathologic Diagnosis

scholarly journals Dermatomyositis in the practice of a neurologist of the department of emergency neurology

2017 ◽  
Vol 98 (2) ◽  
pp. 267-271
Author(s):  
T V Matveeva ◽  
K E Egorova ◽  
R F Mullayanova
Keyword(s):  
Clinical Picture ◽  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Smooth Muscles ◽  
Connective Tissue Diseases ◽  
Skin Lesions ◽  
Demyelinating Polyneuropathy ◽  
Disease Course ◽  
Acute Inflammatory Demyelinating Polyneuropathy ◽  
Inflammatory Demyelinating Polyneuropathy ◽  
Emergency Neurology

Dermatomyositis is a disease from the group of diffuse connective tissue diseases mainly affecting the cross-striated and smooth muscles. The leading disorders in the clinical picture of dermatomyositis are movement disorders, which are often regarded to as a manifestation of acute inflammatory demyelinating polyneuropathy. Also skin lesions in the form of erythema and edema are characteristic, in the absence of these manifestations the term «polymyositis» is used. The disease proceeds with the development of severe neurological symptoms, and is dangerous because of complications which can lead to patient’s death. The article contains a description of cases of two female patients with the initial diagnosis of «Guillain-Barre syndrome». The analysis of the clinical picture, paraclinical studies, features of the disease course in patients was performed, and it enables differential diagnosis between acute/chronic inflammatory demyelinating polyneuropathy and dermatomyositiss at early stages of the disease.

scholarly journals Differential diagnosis of rosacea

2020 ◽  
Vol 23 (1) ◽  
pp. 50-56
Author(s):  
Vsevolod G. Akimov ◽  
L. S. Kruglova
Keyword(s):  
Differential Diagnosis ◽  
Clinical Picture ◽  
Clinical Signs ◽  
Diagnostic Errors ◽  
Skin Lesions ◽  
Facial Skin ◽  
Skin Erythema

The clinical picture of rosacea, including facial skin erythema, telangiectasia, and popular, and pustular elements, is similar to other dermatoses, thereby causing difficulties in the differential diagnosis. Original photos and descriptions of the clinical signs that distinguish these diseases from rosacea are provided. Therefore, the possibility of rare skin lesions that are sometimes mistaken for a more frequent pathology should be considered to avoid diagnostic errors.

scholarly journals Sarcoid-like lesions in paracoccidioidomycosis: immunological factors*

2013 ◽  
Vol 88 (1) ◽  
pp. 113-116 ◽  
Author(s):  
Vanessa Lucília Silveira de Medeiros ◽  
Lúcia Arruda
Keyword(s):  
Immune Response ◽  
Clinical Picture ◽  
Clinical Presentation ◽  
Skin Lesions ◽  
Host Immunity ◽  
Spontaneous Cure ◽  
Long Time ◽  
Immunological Factors ◽  
Different Levels ◽  
Active Disease

The clinical presentation of paracoccidioidomycosis is spectral. Spontaneous cure, state of latency or active disease with different levels of severity can occur after the hematogenous dissemination. The morphology and number of skin lesions will depend on the interaction of host immunity, which is specific and individual, and fungus virulence. Some individuals have natural good immunity, which added to the low virulence of the fungus maintain the presence of well-marked granulomas with no microorganism and negative serology for a long time, making the diagnosis a challenge. Factors inherent to the fungus, however, may modulate the immune response and modify the clinical picture over the time. We present a sarcoidosis-like clinical presentation and discuss the immunological factors involved.

scholarly journals Congenital Nasal Chondromesenchymal Hamartoma

2009 ◽  
Vol 24 (2) ◽  
pp. 23-26
Author(s):  
Ruth S. Estimar ◽  
Mario Adrian M. Zafra ◽  
Ramon Antonio B. Lopa
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Malignant Tumor ◽  
Clinical Picture ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Histopathologic Diagnosis ◽  
Design Case ◽  
One Year ◽  
Nasal Chondromesenchymal Hamartoma

Objectives: To report the case of a congenital nasal chondromesenchymal hamartoma in a one-year-old female and review the literature, identifying problems encountered in confirming the diagnosis and in treatment of this patient. Methods: Design: Case Report  Setting: Tertiary Public General Hospital Patient: One Results: A one-year-old female with an intranasal mass noted at birth and with subsequent unilateral maxillary enlargement is described. Computed tomography showed calcifications and erosion of adjacent bony structures. Histopathology and immunohistochemistry of an intranasal biopsy were interpreted as chordoma, a malignant tumor. Following surgical excision, the final histopathologic diagnosis was chondroid hamartoma. Conclusion: Only 20 cases of nasal chondromesenchymal hamartoma have been reported in the literature worldwide. These tumors may present clinically, histopathologicaly and radiologically as malignant tumors and may mislead even the experts. The whole clinical picture should be taken together to avoid misdiagnosis as a malignancy and to facilitate appropriate management.  Keywords: nasal chondromesenchymal hamartoma, nasal masses in infancy, nasal chondroid lesions

scholarly journals The Dermatological Manifestations in the Coronavirus Infection COVID-19

2020 ◽  
Vol 10 (6) ◽  
pp. 422-429
Author(s):  
A. S. Dvornikov ◽  
A. A. Silin ◽  
T. A. Gaydina ◽  
V. N. Larina ◽  
P. A. Skripkina ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Clinical Picture ◽  
Viral Infections ◽  
Skin Lesions ◽  
The Novel ◽  
Skin Manifestations ◽  
Depth Analysis ◽  
Vesicular Rash ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The variety of dermatological manifestations in patients with the novel coronavirus infection COVID-19, the incidence of which depends on concomitant pathology and the characteristics of drug treatment, and their characteristics are similar to those that occur with conventional viral infections is discussed. At the present time it is proposed to distinguish several groups depending on the cause and mechanism of development: angiitis of the skin; papulo-squamous rash and pink lichen; measles rash and infectious erythema; papulo-vesicular rash; toxidermia; urticarial eruptions and artifical lesions. The variety of the clinical picture of the skin manifestations of coronavirus infection requires in-depth analysis in order to interpret correctly the skin lesions and other infectious exanthema and dermatoses in patients with COVID-19.

scholarly journals Relationship between type of skin lesions and nailfold capillaroscopy pattern in mixed connective tissue disease

2021 ◽  
Author(s):  
Anna Felis-Giemza ◽  
Sylwia Ornowska ◽  
Ewa Haładyj ◽  
Zenobia Czuszyńska ◽  
Marzena Olesińska
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Lupus Erythematosus ◽  
Clinical Picture ◽  
Mixed Connective Tissue Disease ◽  
Skin Lesions ◽  
Systemic Lupus ◽  
Skin Changes

Abstract Introduction Mixed connective tissue disease (MCTD) is a rare disease with clinical picture consisted of multiple organ manifestations, including skin changes resembling systemic lupus erythematosus (SLE), systemic sclerosis (SSc), or dermatomyositis (DM). On the background of these manifestations are microvascular changes — alteration of endothelial function and impairment of endothelial progenitor cell. Nailfold capillaroscopy (NFC) is a simple, non-invasive technique for investigating microvascular involvement in rheumatic diseases. Objectives To describe the relationship between type of skin lesions and NFC pattern in MCTD patients. Methods We analyzed the clinical picture and NFC patterns in 79 patients with MCTD. The NFC changes were classified into Normal, “Early,” “Active,” and “Late” scleroderma-like patterns (SD-like pattern) based on Cutolo classification. In all patients, subjective and physical examinations were carried out, specifically the occurrence of skin lesions in the course of MCTD was assessed (systemic sclerosis-like (Ssc-like), systemic lupus erythematosus-like (SLE-like), dermatomysitis-like (DM-like)). Results Skin changes were present in 64 (81%) patients, involving 43 (54%) SLE-like, 48 (61%) SSc-like, and 4 (5.1%) DM-like. NFC changes were observed in a total of 55 (69.6 %) patients with predominance of the “Early” pattern — 41 (51.9 %) patients. According to skin change phenotypes, NFC changes were observed in 31 (72%) patients with SLE-like and in 32 (66.7%) patients with SSc-like skin phenotypes. The “early” pattern predominated in both group. Conclusions We did not find any correlation between NFC pattern and the type skin changes. Key Points• The study did not show a correlation between the presence and absence of skin lesions and NFC pattern.• Scleroderma-like patterns were found in over 60% of patients with mixed connective tissue disease.• The “early” pattern is dominant regardless of the occurrence or absence of skin lesions in patients with MCTD.• Skin lesions, regardless of their type (SLE or SSc), do not correlate with type of lesion found in the NFC examination.

The Clinical Picture: A woman with ulcerating, painful skin lesions

2008 ◽  
Vol 75 (6) ◽  
pp. 414-422
Author(s):  
M. P. PILIANG ◽  
J. K. STOLLER
Keyword(s):  
Clinical Picture ◽  
Skin Lesions
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