Duration of symptoms does not correlate with results of T-cell gene rearrangement studies in patients evaluated for cutaneous T-cell lymphoma

2015 ◽  
Vol 42 (9) ◽  
pp. 618-621
Author(s):  
Allison R. Larson ◽  
Scott Rodig ◽  
Scott R. Granter
Keyword(s):  
T Cell ◽  
Gene Rearrangement ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Duration Of Symptoms ◽  
Cell Gene

Cutaneous T-cell lymphoma severity index and T-cell gene rearrangement

The Lancet ◽  
1997 ◽  
Vol 350 (9093) ◽  
pp. 1776-1777 ◽  
Author(s):  
E Dippel ◽  
S Goerdt ◽  
C Assaf ◽  
H Stein ◽  
CE Orfanos
Keyword(s):  
T Cell ◽  
Gene Rearrangement ◽  
Cell Lymphoma ◽  
Severity Index ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Cell Gene

scholarly journals A Longstanding, Persistent and Recurrent Case of Cryptogenic Panniculitis

2020 ◽  
Vol 12 (3) ◽  
pp. 199-208
Author(s):  
Tatsiana Pukhalskaya ◽  
J. Ahmad Brown ◽  
Adam A. Sills ◽  
Bruce R. Smoller
Keyword(s):  
T Cell ◽  
Gene Rearrangement ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous Lesions ◽  
Plantar Surface ◽  
Lupus Profundus ◽  
Significant Clinical Improvement ◽  
Scalp Biopsy ◽  
Cell Gene

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of cutaneous T-cell lymphoma. There may be a significant histologic overlap with traumatic panniculitis and lupus profundus. We describe a 54-year-old woman who had received a diagnosis of SPTCL based upon a left parietal scalp biopsy 5 years earlier. This diagnosis was supported by immunohistochemistry (IHC) demonstrating a CD8+ predominant lymphocyte population in the subcutis. T-cell gene rearrangement studies were not performed at that time. The patient was treated and showed significant clinical improvement. When several tender erythematous subcutaneous nodules appeared on the upper back, left plantar surface and pretibial region, repeat biopsy was performed. Histology revealed a lobular and septal panniculitis with no vasculitis. The infiltrate contained abundant eosinophils and histiocytes not seen in the original biopsy specimen. IHC demonstrated a mixture of CD4+, CD8+ and CD7+ lymphocytes with abundant CD68+ histiocytes. T-cell gene rearrangement studies performed on one of the lesions failed to demonstrate clonality. It is important to recognize that patients with SPTCL are not exempt from other types of panniculitis, and complete histologic, IHC and molecular workups are essential to properly classify all cutaneous lesions in these patients.

Dual Genotype in Cutaneous T Cell Lymphoma: Immunoglobulin Gene Rearrangement in Clonal T Cell Malignancy

1988 ◽  
Vol 90 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Carol L. Berger ◽  
Arthur. Eisenberg ◽  
Laurie. Soper ◽  
John. Chow ◽  
James. Simone ◽  
...  
Keyword(s):  
T Cell ◽  
Gene Rearrangement ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Immunoglobulin Gene ◽  
Cutaneous T Cell Lymphoma ◽  
Immunoglobulin Gene Rearrangement ◽  
Cell Malignancy

scholarly journals Utility of flow cytometry and gene rearrangement analysis in tissue and blood of patients with suspected cutaneous T‑cell lymphoma

2020 ◽  
Vol 45 (1) ◽  
pp. 349-358
Author(s):  
Julie Gibbs ◽  
Sophia Ma ◽  
Anna Kim ◽  
Lucia Seminario‑Vidal ◽  
Lubomir Sokol ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
T Cell ◽  
Gene Rearrangement ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Gene Rearrangement Analysis

scholarly journals T-Cell Receptor-G Gene Rearrangement Analysis in the Diagnosis of Patients with Erythroderma / Dijagnostički Značaj Analize Preuređenja Gena Gama Lanca T-Ćelijskog Receptora Kod Pacijenata Sa Eritrodermijom

2009 ◽  
Vol 1 (1) ◽  
pp. 17-26
Author(s):  
Lidija Kandolf-Sekulović ◽  
Bojana Cikota ◽  
Miroslav Dinić ◽  
Dušan Škiljević ◽  
Zvonko Magić
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Peripheral Blood ◽  
Gene Rearrangement ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Inflammatory Dermatosis ◽  
Gene Rearrangement Analysis

Abstract The diagnosis of erythroderma is challenging, since clinical, histopathological and immunophenotypic findings are insufficient to differentiate between inflammatory and lymphomatous erythroderma. Thus, multiplex PCR was used for T-cell receptor-γ gene rearrangement analysis, in the skin and peripheral blood samples of 24 patients (20 men and 4 women) with erythroderma of varying origin, in order to estimate its diagnostic value. Cutaneous T-cell lymphoma was confirmed in 9, benign inflammatory dermatosis in 12, and idiopathic erythroderma and clonal dermatitis in 3 patients. In the group of patients with erythrodermic cutaneous T-cell lymphoma, the dominant clone was detected in the skin of 8/9, and in none of the patients with inflammatory dermatoses. A dominant clone was found in peripheral blood of 5/6 samples of patients with erythrodermic cutaneous T-cell lymphoma, and in 2/12 patients with inflammatory dermatosis. T-cell receptor-γ gene rearrangement analysis is valuable in differentiation between inflammatory and lymphomatous erythroderma, thus substantially improving the diagnosis of patients with erythroderma.

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