scholarly journals Increased serum amiodarone concentration in hypertriglyceridemic patients: effects of drug distribution to serum lipoproteins

2021 ◽  
Author(s):  
Naoaki Hashimoto ◽  
Kosuke Doki ◽  
Satoru Kawano ◽  
Kazutaka Aonuma ◽  
Masaki Ieda ◽  
...  
Keyword(s):  
Drug Distribution ◽  
Serum Lipoproteins

Cytopathology of Cardiac Tissue from Daunomycin-Treated Mice

1971 ◽  
Vol 29 ◽  
pp. 550-551
Author(s):  
Robert H. Liss ◽  
Frances A. Cotton
Keyword(s):  
Cardiac Tissue ◽  
Cardiac Toxicity ◽  
Drug Distribution ◽  
Personal Communication ◽  
Intravenous Dose ◽  
Single Intravenous Dose ◽  
Physiologic Saline ◽  
Histopathologic Changes ◽  
Distribution Studies ◽  
Lung And Kidney

Daunomycin, an antibiotic used in the clinical management of acute leukemia, produces a delayed, lethal cardiac toxicity. The lethality is dose and schedule dependent; histopathologic changes induced by the drug have been described in heart, lung, and kidney from hamsters in both single and multiple dose studies. Mice given a single intravenous dose of daunomycin (10 mg/kg) die 6-7 days later. Drug distribution studies indicate that the rodents excrete most of a single dose of the drug as daunomycin and metabolite within 48 hours after dosage (M. A. Asbell, personal communication).Myocardium from the ventricles of 6 moribund BDF1 mice which had received a single intravenous dose of daunomycin (10 mg/kg), and from controls dosed with physiologic saline, was fixed in glutaraldehyde and prepared for electron microscopy.

AUTORADIOGRAPHIC TECHNIQUES FOR THE LOCALIZATION OF HORMONES AND DRUGS AT THE CELLULAR AND SUBCELLULAR LEVEL

1971 ◽  
Vol 68 (1_Suppl) ◽  
pp. S205-S222 ◽  
Author(s):  
Walter E. Stumpf
Keyword(s):  
Drug Distribution ◽  
Photographic Emulsion ◽  
Frozen Sections ◽  
Hormone Research ◽  
Freeze Dried ◽  
Subcellular Level

ABSTRACT The paper describes four autoradiographic techniques which can be recommended, not without restrictions, for the study of the cellular and subcellular hormone or drug distribution in tissues. In all of the techniques desiccated slides are used which are precoated with photographic emulsion. The techniques are (I) Dry-mounting of freeze-dried sections on emulsion precoated slides; (II) Thaw-mounting of frozen sections on emulsion precoated slides; (III) Smear-mounting on emulsion precoated slides; and (IV) Touch-mounting on emulsion precoated slides. The techniques are designed to avoid or minimize translocation of the labelled molecules during preparation and during the application to photographic emulsion. Cited examples of application of these techniques demonstrate their utility in hormone research.

Serum lipoproteins of diabetic rats fed a high cholesterol diet

Diabetes ◽  
1980 ◽  
Vol 29 (10) ◽  
pp. 774-777 ◽  
Author(s):  
C. M. Arbeeny ◽  
D. Edelstein ◽  
S. R. Freedman ◽  
H. A. Eder
Keyword(s):  
Diabetic Rats ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Serum Lipoproteins ◽  
High Cholesterol

Emerging Trends in the Long-acting Antiretroviral Therapy: Current Status and Therapeutic Challenges

2020 ◽  
Vol 18 ◽  
Author(s):  
Rajpushpa Labh ◽  
Rachna Gupta
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Drug Distribution ◽  
Antiretroviral Drugs ◽  
Current Status ◽  
People Living With Hiv ◽  
Viral Reservoirs ◽  
Emerging Trends ◽  
Gradual Development ◽  
Long Acting

: Antiretroviral drug therapy has significantly improved the prognosis and life expectancy of People Living with HIV over the years. But this progress comes with an important caveat that antiretroviral regimens generally require adherence to life-long, daily dosing, to keep viral multiplication under check. Non-adherence to such dosing leads to decreased efficacy and increased drug resistance against antiretroviral drugs. Besides, poor drug penetration to certain tissues like CNS and lymph nodes leads to build-up of viral reservoirs in these sites. To combat some of these challenges and improve patient compliance, long-acting antiretroviral drugs, are a new weapon in the arsenal, in fight against HIV. Few long acting preparations have been approved, and several others are in various clinical and preclinical stages of development. However, longacting formulations also have their share of clinical issues like limited drug distribution, long term adverse drug reactions, drug-drug interactions, and gradual development of drug resistance. Modern technological premises are being tested to mitigate some of these problems. One such promising approach involves nanotechnological methods, which are being used to develop ultra-long acting formulations and drug delivery systems, targeting tissues with residual HIV concentration. LongActing Slow Effective Release Antiretroviral Therapy aka LASER ART, also builds on nanotechnology and prodrug modifications to design preparations with tailor-made favorable pharmacokinetics and wider drug distribution. These recent advances are fueling the progression of antiretroviral therapy towards eliminating the disease.

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