Model‐informed assessment of ethnic sensitivity and dosage justification for Asian populations in the global clinical development and use of cladribine tablets

Psychosomatic Symptoms in Asian Populations: More Than a Headache?

PsycEXTRA Dataset ◽

10.1037/e528472014-054 ◽

2014 ◽

Author(s):

Gen Numaguchi

Keyword(s):

Psychosomatic Symptoms ◽

Asian Populations

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COVID-19 must catalyse changes to clinical development

Nature Reviews Drug Discovery ◽

10.1038/d41573-020-00149-2 ◽

2020 ◽

Vol 19 (10) ◽

pp. 653-654

Author(s):

Rod MacKenzie ◽

Peter Honig ◽

Judy Sewards ◽

Robert Goodwin ◽

Marie-Pierre Hellio

Keyword(s):

Clinical Development

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Curcumin: New trends in the formulative and clinical development

Planta Medica ◽

10.1055/s-0034-1382337 ◽

2014 ◽

Vol 80 (10) ◽

Cited By ~ 1

Author(s):

P Morazzoni ◽

A Riva ◽

M Ronchi ◽

G Petrangolini ◽

W Cabri

Keyword(s):

Clinical Development

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Immunogenicity of Mepolizumab in Patients with Severe Eosinophilic Asthma: Experience from the Clinical Development Program

10.1055/s-0039-1678313 ◽

2019 ◽

Author(s):

H Ortega ◽

E Meyer ◽

G Brusselle ◽

K Asano ◽

RG Price ◽

...

Keyword(s):

Development Program ◽

Clinical Development ◽

Eosinophilic Asthma ◽

Severe Eosinophilic Asthma ◽

Clinical Development Program

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EVALUATION OF OCCURRENCE OF HYPERDONTIA IN NON-SYNDROMIC POPULATION FROM BIHAR REGION

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i10.740 ◽

2019 ◽

Vol 3 (10) ◽

Author(s):

Dr. Minti Kumari ◽

Dr. Madhuri Kumari ◽

Dr Anurag Rai ◽

Dr. Navin Kumar

Keyword(s):

Panoramic Radiograph ◽

Permanent Dentition ◽

Dental Anomalies ◽

Supernumerary Teeth ◽

Panoramic Radiographs ◽

Future Studies ◽

Asian Populations ◽

Males And Females ◽

The Individual ◽

Clinical Records

It is evident that hyperdontia is more common in the permanent dentition than in the primary. There is a considerable difference between males and females in the prevalence of these teeth in permanent dentition; hyperdontia is twice as common in males as in females. However, this approximation varies in terms of location, other associating syndromes that may be present, and the ethnicity of the individual. In terms of ethnicity, it can be seen that hyperdontia is in fact less common in Caucasian than in Asian populations. There is evidence to show that an individual is more likely to have hyperdontia if other members of their family also have the condition. Hence the present study was planned for evaluation of occurrence of hyperdontia in non-syndromic population from Bihar Region. The present study was planned in Public Health Dentistry, Patna Dental College and Hospital, Patna, Bihar. Total 195 patients referred to Department of Dentistry were evaluated in the present study. Panoramic radiographs and clinical records of patients above the age of 18 years and without any syndromic features were selected for the study. All the radiographs were examined for the presence of supernumerary teeth, their location, morphology, and number. Morphologically, teeth were classified as conical, tuberculate, supplemental, and odontoma. Early diagnosis of dental anomalies can prevent some esthetic, orthodontic, and periodontal problems, and knowledge of the prevalence and distribution of the anomalies may help clinicians to the detection of these anomalies at early stages. Our study evaluated the prevalence of selected dental anomalies; future studies should investigate the prevalence of dental anomalies of all types. Keywords: Hyperdontia, non-syndromic, panoramic radiograph, supernumerary teeth, etc.

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Gene Polymorphisms and Their Association to Coronavirus Family Infections: Susceptibility in Different Populations

Medical & Clinical Research ◽

10.33140/mcr.05.012 ◽

2020 ◽

Vol 5 ◽

Keyword(s):

Genetic Variants ◽

Viral Infections ◽

Human Leukocyte ◽

Asian Population ◽

African Region ◽

Mediterranean Populations ◽

Susceptibility To Infection ◽

Asian Populations ◽

Spread Pattern ◽

Different Populations

Human leukocyte antigen (HLA) loci are highly polymorphic and determine differential features of the immune response in subjects from different regions. HLA genes have been proposed to determine genetic susceptibility to several diseases, particularly to viral infections. Moreover, it has been suggested that each ethnic group could have a different specificity of T-lymphocyte reactivity to the same viral infections. In this review, we analyzed the distribution of HLA types in countries of the Asian, European and North African region. Also, we studied the relation between these HLA polymorphisms and susceptibility to infection by the coronavirus. Our findings indicated that homozygosity would increase susceptibility to viral infections and, in some cases, to coronavirus infection. HLA types showing higher susceptibility were reported in Asian population, including China, Singapore, and Taiwan. In contrast, lower susceptibility HLA variants were detected among African populations, some Asian populations, and Mediterranean populations. The presented evidence along with the spread pattern of COVID-19 infection suggests that HLA genetic variants might be related to its infection susceptibility and severity. The investigation of HLA genetic variants distribution would be a useful tool to predict different populations’ susceptibility to viral infections.

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