scholarly journals Pharmacokinetics and safety of a novel influenza treatment (baloxavir marboxil) in Korean subjects compared with Japanese subjects

2021 ◽  
Author(s):  
Yun Kim ◽  
Sangwon Lee ◽  
Yohan Kim ◽  
In‐Jin Jang ◽  
SeungHwan Lee
Keyword(s):  
Japanese Subjects

Identification of mutations in the hepatocyte nuclear factor (HNF)-1 alpha gene in Japanese subjects with IDDM

Diabetes ◽  
1997 ◽  
Vol 46 (10) ◽  
pp. 1643-1647 ◽  
Author(s):  
S. Yamada ◽  
H. Nishigori ◽  
H. Onda ◽  
T. Utsugi ◽  
T. Yanagawa ◽  
...  
Keyword(s):  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Alpha Gene ◽  
Japanese Subjects

Polymorphism of the Apolipoprotein E and Angiotensin-Converting Enzyme Genes in Japanese Subjects With Silent Myocardial Ischemia

Hypertension ◽  
1996 ◽  
Vol 27 (6) ◽  
pp. 1205-1209 ◽  
Author(s):  
Yukiko Nakata ◽  
Tomohiro Katsuya ◽  
Hiromi Rakugi ◽  
Seiju Takami ◽  
Mitsuru Ohishi ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Angiotensin Converting Enzyme ◽  
Apolipoprotein E ◽  
Silent Myocardial Ischemia ◽  
Converting Enzyme ◽  
Japanese Subjects

Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources

2021 ◽  
Vol 38 ◽  
pp. 100387
Author(s):  
Makiko Shimizu ◽  
Natsumi Koibuchi ◽  
Ami Mizugaki ◽  
Eiji Hishinuma ◽  
Sakae Saito ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Japanese Subjects

scholarly journals Effects of AGXT2 variants on blood pressure and blood sugar among 750 older Japanese subjects recruited by the complete enumeration survey method

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yuta Yoshino ◽  
Hiroshi Kumon ◽  
Takaaki Mori ◽  
Taku Yoshida ◽  
Ayumi Tachibana ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Blood Sugar ◽  
Vascular Diseases ◽  
Survey Method ◽  
Nucleotide Polymorphisms ◽  
Complete Enumeration ◽  
Plasma Adma ◽  
Oxide Synthase ◽  
Japanese Subjects

Abstract Background Alanine:glyoxylate aminotransferase 2 (AGXT2; EC 2.6.1.44) is the only enzyme that degrades the R-form of 3-aminoisobutyrate, an intermediate metabolite of thymine. AGXT2, as well as diaminoarginine dimethylaminohydrolase 1 (DDAH1; EC 3.5.3.18), works as an enzyme that degrades asymmetric dimethylarginine (ADMA), which competitively inhibits the nitric oxide synthase family. Thus, these two enzyme activities may change vascular vulnerability for a lifetime via the nitric oxide (NO) system. We investigated the association between vascular conditions and diseases such as hypertension and diabetes mellitus and polymorphisms of these two genes in 750 older Japanese subjects (mean age ± standard deviation, 77.0 ± 7.6 years) recruited using the complete enumeration survey method in the Nakayama study. Demographic and biochemical data, such as blood pressure (BP) and casual blood sugar (CBS), were obtained. Four functional single nucleotide polymorphisms (SNPs; rs37370, rs37369, rs180749, and rs16899974) of AGXT2 and one functional insertion/deletion polymorphism in the promotor region with four SNPs (rs307894, rs669173, rs997251, and rs13373844) of DDAH1 were investigated. Plasma ADMA was also analyzed in 163 subjects. Results The results of multiple regression analysis showed that a loss of the functional haplotype of AGXT2, CAAA, was significantly positively correlated with BP (systolic BP, p = 0.034; diastolic BP, p = 0.025) and CBS (p = 0.021). No correlation was observed between DDAH1 and either BP or CBS. ADMA concentrations were significantly elevated in subjects with two CAAA haplotypes compared with subjects without the CAAA haplotype (p = 0.033). Conclusions Missense variants of AGXT2, but not DDAH1, may be related to vulnerability to vascular diseases such as hypertension and DM via the NO system.

scholarly journals Effects of Daily Kelp (Laminaria japonica) Intake on Body Composition, Serum Lipid Levels, and Thyroid Hormone Levels in Healthy Japanese Adults: A Randomized, Double-Blind Study

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 352
Author(s):  
Seiichiro Aoe ◽  
Chiemi Yamanaka ◽  
Hirofumi Ohtoshi ◽  
Fumiko Nakamura ◽  
Suguru Fujiwara
Keyword(s):  
Thyroid Hormone ◽  
Body Fat ◽  
Laminaria Japonica ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Double Blind ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels ◽  
Male Subjects ◽  
Japanese Subjects

To investigate whether supplementation with iodine-reduced kelp (Laminaria japonica) powder decreases body fat composition in overweight Japanese subjects, a randomized, double-blind, placebo-controlled intervention study was conducted in 50 Japanese subjects with body mass index (BMI) ≥25 and <30 kg/m2. Subjects were randomly assigned to consume thirty tablets/d (10 tablets orally, 3 times/d) containing either iodine-reduced kelp powder (test, 6 g kelp powder corresponding to 3 g alginate/d) or kelp-free powder (placebo) for 8 weeks. Anthropometric measurements, blood lipids, and serum thyroid hormone levels were obtained before and after the trial. Body fat percentage was significantly decreased in male subjects from the test group compared with the placebo group. The same tendency was observed for body weight (p = 0.065) and BMI (p = 0.072) in male subjects. No significant changes in anthropometric measurements or visceral fat area were observed in female subjects. Serum thyroid hormone concentrations did not increase after 1.03 mg/d of iodine supplementation through kelp intake. The intake of iodine-reduced kelp powder led to significant and safe reductions in body fat percentage in overweight male subjects. The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.

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