scholarly journals Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial

2021 ◽  
Author(s):  
Kine Eide Kvitne ◽  
Ida Robertsen ◽  
Eva Skovlund ◽  
Hege Christensen ◽  
Veronica Krogstad ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Body Weight ◽  
Calorie Restriction ◽  
Controlled Trial ◽  
Body Weight Loss ◽  
Cyp3a Activity ◽  
Long Term Effects ◽  
Short And Long Term

Short- and Long-Term Effects of Weight Loss on the Complement Component C3 After Laparoscopic Gastric Bypass in Obese Patients

2016 ◽  
Vol 26 (11) ◽  
pp. 2756-2763 ◽  
Author(s):  
Segundo Á. Gómez-Abril ◽  
Carlos Morillas-Ariño ◽  
Jose L. Ponce-Marco ◽  
Teresa Torres-Sánchez ◽  
Fernando Delgado-Gomis ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Laparoscopic Gastric Bypass ◽  
Complement Component ◽  
Obese Patients ◽  
Long Term Effects ◽  
Complement Component C3 ◽  
Short And Long Term

scholarly journals Weight Maintenance with Litramine (IQP-G-002AS): A 24-Week Double-Blind, Randomized, Placebo-Controlled Study

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Barbara Grube ◽  
Pee-Win Chong ◽  
Felix Alt ◽  
Ralf Uebelhack
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Controlled Trial ◽  
Weight Maintenance ◽  
Body Weight Loss ◽  
Controlled Study ◽  
Serious Adverse Events ◽  
Double Blind ◽  
Initial Weight Loss

Background.Litramine (IQP-G-002AS) was shown to be effective and safe for weight loss in overweight and obese subjects. However, long-term effectiveness on maintenance of body weight loss has yet to be ascertained.Objective.To assess effect of Litramine on maintenance of body weight loss.Methods.A double-blind, randomised, placebo-controlled trial on overweight and obese patients was conducted over two sites in Germany for 24 weeks. Subjects with documented previous weight loss of 3% over the last 3–6 months were randomised to groups given either Litramine (3 g/day) or a matching placebo. Primary endpoints were difference of mean body weight (kg) between baseline and end of study and maintenance of initially lost body weight in verum group, where maintenance is defined as ≤1% weight gain.Results.Subjects who were taking Litramine lost significantly more body weight compared to the subjects taking placebo who gained weight instead (-0.62±1.55 kg versus1.62±1.48 kg,p<0.001). More importantly, 92% of subjects in Litramine group were able to maintain their body weight after initial weight loss, versus 25% in placebo group. No serious adverse events were reported throughout.Conclusion.Litramine is effective and safe for long-term body weight maintenance.Trial Registration.This trial is registered with Clinicaltrials.gov identifier:NCT01505387.

Gastric Bypass Surgery Causes Body Weight Loss Without Reducing Food Intake in Rats

2008 ◽  
Vol 18 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Marianne W. Furnes ◽  
Karin Tømmerås ◽  
Carl-Jørgen Arum ◽  
Chun-Mei Zhao ◽  
Duan Chen
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Body Weight ◽  
Food Intake ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Body Weight Loss

Characterization of one anastomosis gastric bypass and impact of biliary and common limbs on bile acid and postprandial glucose metabolism in a minipig model

2021 ◽  
Author(s):  
Camille Marciniak ◽  
Oscar Chávez-Talavera ◽  
Robert Caiazzo ◽  
Thomas Hubert ◽  
Lorea Zubiaga ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Body Weight ◽  
Glucose Metabolism ◽  
Glucose Homeostasis ◽  
Body Weight Loss ◽  
Metabolic Effects ◽  
One Anastomosis Gastric Bypass ◽  
Alimentary Limb ◽  
The Common

Background/Objectives: The alimentary limb has been proposed to be a key driver of the weight-loss-independent metabolic improvements that occur upon bariatric surgery. However, the One Anastomosis Gastric Bypass (OAGB) procedure, consisting of one long biliary limb and a short common limb, induces stronger beneficial metabolic effects compared to Roux-en-Y Gastric Bypass (RYGB) in humans, despite the lack of an alimentary limb. The aim of this study was to assess the role of the biliary and common limbs in the weight-loss and metabolic effects that occur upon OAGB. Subjects/Methods: OAGB and sham surgery, with or without modifications of the length of either the biliary limb or the common limb, were performed in Gottingen-like minipigs. Weight loss, metabolic changes, and the effects on plasma and intestinal bile acids (BAs) were assessed 15 days after surgery. Results: OAGB significantly decreased body weight, improved glucose homeostasis, increased postprandial GLP-1 and fasting plasma BAs, and qualitatively changed the intestinal BA species composition. Resection of the biliary limb prevented the body weight loss effects of OAGB and attenuated the postprandial GLP-1 increase. Improvements in glucose homeostasis along with changes in plasma and intestinal BAs occurred after OAGB regardless of the biliary limb length. Resection of only the common limb reproduced the glucose homeostasis effects and the changes in intestinal BAs. Conclusions: Our results suggest that the changes in glucose metabolism and BAs after OAGB are mainly mediated by the length of the common limb, whereas the length of the biliary limb contributes to body weight loss.

Controlled trial of the metabolic effects of a very-low-calorie diet: short- and long-term effects

1990 ◽  
Vol 51 (2) ◽  
pp. 167-172 ◽  
Author(s):  
G D Foster ◽  
T A Wadden ◽  
I D Feurer ◽  
A S Jennings ◽  
A J Stunkard ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Metabolic Effects ◽  
Long Term Effects ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Short And Long Term

scholarly journals The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis – a randomised controlled trial

2014 ◽  
Vol 15 (1) ◽  
pp. 44 ◽  
Author(s):  
Annemarie L Lee ◽  
Catherine J Hill ◽  
Nola Cecins ◽  
Sue Jenkins ◽  
Christine F McDonald ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Randomised Controlled Trial ◽  
Exercise Training ◽  
Controlled Trial ◽  
Long Term Effects ◽  
Short And Long Term ◽  
Randomised Controlled
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