scholarly journals Tilidine and dipyrone (metamizole) in cold pressor pain: A pooled analysis of efficacy, tolerability, and safety in healthy volunteers

2021 ◽  
Author(s):  
Julian Kleine‐Borgmann ◽  
Johannes Wilhelmi ◽  
Johannes Kratel ◽  
Frederik Baumann ◽  
Katharina Schmidt ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Cold Pressor ◽  
Pooled Analysis ◽  
Cold Pressor Pain

Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?

2016 ◽  
Vol 124 (2) ◽  
pp. 453-463 ◽  
Author(s):  
Eckhard Mauermann ◽  
Joerg Filitz ◽  
Patrick Dolder ◽  
Katharina M. Rentsch ◽  
Oliver Bandschapp ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Pain Perception ◽  
Rating Scale ◽  
Cold Pressor ◽  
High Dose ◽  
Double Blind ◽  
Additional Measure ◽  
Pain Scores ◽  
Cold Pressor Pain ◽  
Fentanyl Administration

Abstract Background Although opioids in general and remifentanil in particular have been shown to induce hyperalgesia, data regarding fentanyl are scarce. Thus, the authors investigated the effect of fentanyl dosing on pain perception and central sensitization in healthy volunteers using established pain models. Methods Twenty-one healthy, male volunteers were included in this randomized, double-blind, crossover study and received either intravenous low-dose (1 μg/kg) or high-dose (10 μg/kg) fentanyl. Pain intensities and hyperalgesia were assessed by intracutaneous electrical stimulation, and cold pressor pain was used as an additional measure of acute pain. The primary outcome was hyperalgesia from 4.5 to 6.5 h after fentanyl administration. Results A higher dose of fentanyl led to significantly decreased pain scores as measured by the numeric rating scale (0.83 units lower [95% CI, 0.63 to 1.02]; P < 0.001) but increased areas of hyperalgesia (+30.5% [95% CI, 16.6 to 44.4%]; P < 0.001) from 4.5 to 6.5 h after fentanyl administration. Allodynia did not differ between groups (+4.0% [95% CI, −15.4 to 23.5%]; P = 0.682).The high dose also led to both increased cold pressor pain threshold (+43.0% [95% CI, 29.7 to 56.3%]; P < 0.001) and tolerance (+32.5% [95% CI, 21.7 to 43.4%]; P < 0.001) at 4.5 to 6.5h. In the high-dose group, 19 volunteers (90%) required reminders to breathe, 8 (38%) required supplemental oxygen, and 12 (57%) experienced nausea. Conclusions A higher dose of fentanyl increased hyperalgesia from 4.5 to 6.5 h in healthy volunteers while simultaneously decreasing pain scores.

Effects of active alert and relaxation hypnotic inductions on cold pressor pain.

1991 ◽  
Vol 100 (2) ◽  
pp. 223-226 ◽  
Author(s):  
Mary F. Miller ◽  
Arreed F. Barabasz ◽  
Marianne Barabasz
Keyword(s):  
Cold Pressor ◽  
Cold Pressor Pain

Subject Expectancy and the Reduction of Cold Pressor Pain with Acupuncture and Placebo Acupuncture

1979 ◽  
Vol 41 (6) ◽  
pp. 477-486 ◽  
Author(s):  
Jane V. Knox ◽  
Carol E. Handfield-Jones ◽  
Kit Shum
Keyword(s):  
Cold Pressor ◽  
Placebo Acupuncture ◽  
Cold Pressor Pain

A comparison of the effects of preferred music, arithmetic and humour on cold pressor pain

2006 ◽  
Vol 10 (4) ◽  
pp. 343-343 ◽  
Author(s):  
Laura A. Mitchell ◽  
Raymond A.R. MacDonald ◽  
Eric E. Brodie
Keyword(s):  
Cold Pressor ◽  
Cold Pressor Pain

scholarly journals Swearing as a response to pain: Assessing hypoalgesic effects of novel “swear” words

2019 ◽  
Author(s):  
Richard Stephens ◽  
Olly May Robertson
Keyword(s):  
Heart Rate ◽  
Repeated Measures ◽  
Neutral Word ◽  
Pain Threshold ◽  
Pain Perception ◽  
Cold Pressor ◽  
Pain Tolerance ◽  
Mediation Effects ◽  
Independent Variable ◽  
Cold Pressor Pain

Background: This pre-registered study extends previous findings that swearing alleviates pain tolerance by assessing the effects of a conventional swear word (“fuck”) and two new “swear” words, “fouch” and “twizpipe”.Method: A mixed sex group of participants (N = 92) completed a repeated measures experimental design augmented by mediation analysis. The independent variable was Word with the levels, “fuck” v. “fouch” v. “twizpipe” v. a neutral word. The dependent variables were emotion rating, humour rating, distraction rating, cold pressor pain threshold, cold pressor pain tolerance, pain perception score and change from resting heart rate. Possible mediation effects were assessed for emotion, humour and distraction ratings. Results: For conventional swearing (“fuck”), confirmatory analyses found a 32% increase in pain threshold and a 33% increase in pain tolerance, accompanied by increased ratings for emotion, humour and distraction, relative to the neutral word condition. The new “swear” words, “fouch” and “twizpipe” were rated higher than the neutral word for emotion and humour although these words did not affect pain threshold or tolerance. Changes in heart rate, pain perception and were absent, as were mediation effects.Conclusions: Our data replicate previous findings that repeating a swear word at a steady pace and volume benefits pain tolerance, extending this finding to pain threshold. Our data cannot explain how such effects are manifest, although distraction appears to be of little importance, and emotion is worthy of future study. The new “swear” words did not alleviate pain even though participants rated them as emotion evoking and humorous.

A Multidisciplinary Approach to the Expression of Pain in Psychic Depression

1978 ◽  
Vol 47 (2) ◽  
pp. 379-390 ◽  
Author(s):  
Judith R. Ganchrow ◽  
Jacob E. Steiner ◽  
Murray Kleiner ◽  
Eliezer L. Edelstein
Keyword(s):  
Heart Rate ◽  
Multidisciplinary Approach ◽  
Rating Scale ◽  
Cold Pressor ◽  
Facial Display ◽  
Pain Stimulus ◽  
Verbal Responses ◽  
Depressed Patients ◽  
Facial Displays ◽  
Cold Pressor Pain

The expression of cold pressor pain was measured by recording simultaneously verbal magnitude estimates, heart rates, and facial displays of 16 recently hospitalized depressed patients, and 16 nondepressed adults. Independence of the two groups for the depression factor was verified using the Hamilton Scale for Depression and the 100-mm line self-rating scale. Verbal responses and amount of time the ice bath was tolerated, as well as heart-rate measures, indicated that depressed individuals were significantly more sensitive to the pain stimulus. However, this elevated intolerance to pain was not reflected by marked changes of facial display. Reasons for this discrepancy are discussed. Nondepressed subjects, although clearly able to verbalize intensity of pain, were much less reactive to the pain along all dimensions.

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