scholarly journals A Metabolomic Analysis of Thiol Response for Standard and Modified N‐Acetyl Cysteine Treatment Regimens in Patients With Acetaminophen Overdose

2021 ◽  
Author(s):  
James W Dear ◽  
Mei Li Ng ◽  
D Nicholas Bateman ◽  
Pakkiri Leroy Sivappiragasam ◽  
Hyungwon Choi ◽  
...  
Keyword(s):  
Metabolomic Analysis ◽  
Acetaminophen Overdose ◽  
Treatment Regimens ◽  
Acetyl Cysteine

scholarly journals Prevention of Lung Complications following Paraquat Poisoning by Silymarin, N-acetyl Cysteine and Hydrocortisone: An Experimental Study

2020 ◽  
Vol 14 (4) ◽  
pp. 193-200
Author(s):  
Mohammad Jamalian ◽  
◽  
Hassan Solhi ◽  
Parisa Ghasemi ◽  
Ali Rahbari ◽  
...  
Keyword(s):  
Oral Dose ◽  
Sprague Dawley ◽  
Once Daily ◽  
Daily Oral Dose ◽  
Treatment Regimens ◽  
Paraquat Poisoning ◽  
Sprague Dawley Rats ◽  
Lung Injuries ◽  
Acetyl Cysteine ◽  
Oral Doses

Background: Paraquat poisoning results in multi-organ failure, primarily pulmonary fibrosis, acute renal failure, and hepatic impairment. The present study was designed to evaluate three treatment regimens, such as N-Acetyl cysteine (NAC), silymarin and hydrocortisone in the prevention of lung fibrosis after ingestion of toxic doses of paraquat in rats.  Methods: Male Sprague-Dawley rats (N=20) were randomly divided into four groups of five each. The drugs and paraquat were given to the rats orally. All rat groups received one oral dose of paraquat (10 mg/kg) once daily for 1 week. The first group received a daily oral dose of silymarin (600 mg/kg) for 2 weeks. The second group received a daily oral dose of NAC (500 mg/kg) for 2 weeks. The third group was given daily oral doses of NAC (500 mg/kg) and hydrocortisone (50 mg/kg) for 2 weeks. The fourth group (controls) received no drugs other than paraquat. The experiment continued for 4 weeks. After the experiment, autopsy was performed on all rats and the lungs were examined histopathologically. Results: The results of histopathology examinations for peribronchial inflammation in the groups were shown that NAC plus hydrocortisone and silymarin had notable effects in the prevention of lung inflammation. Septal widening in the lungs was also observed in group three less than that in the other groups. Conclusion: Based on the results, silymarin, NAC and hydrocortisone may be used as a palliative treatment in paraquat poisoning specifically aimed at preventing the acute and chronic lung injuries as the worst complication of the poisoning.   

N-acetyl-cysteine and H. pylori urease activity

2001 ◽  
Vol 120 (5) ◽  
pp. A589-A589
Author(s):  
H HUYNH ◽  
R COUPER ◽  
C TRAN ◽  
A MUHAMED ◽  
R BUTLER
Keyword(s):  
Urease Activity ◽  
Acetyl Cysteine ◽  
H Pylori

Platelet monitoring for PCI

2009 ◽  
Vol 29 (04) ◽  
pp. 376-380 ◽  
Author(s):  
D. Capodanno ◽  
D. J. Angiolillo
Keyword(s):  
Interindividual Variability ◽  
State Of The Art ◽  
Coronary Intervention ◽  
Functional Tests ◽  
Treatment Regimens ◽  
Advantages And Disadvantages ◽  
Coronary Syndrome ◽  
Combined Use ◽  
Increased Risk ◽  
Percutaneous Coronary

SummaryDespite the clinical benefit associated with the combined use of aspirin and clopidogrel in patients with acute coronary syndrome or those undergoing percutaneous coronary intervention, a considerable interindividual variability in response to these drugs have been consistently reported. There is a growing interest on applying platelet functional tests with the goal of identifying patients at increased risk of recurrent ischaemic events and potentially tailoring antiplatelet treatment regimens.This manuscript will review the state of the art on the most commonly available platelet functional tests, describing their advantages and disadvantages and exploring their applicability in clinical practice.

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