scholarly journals Tissue pharmacokinetics of DHP107, a novel lipid‐based oral formulation of paclitaxel, in mice and patients by positron emission tomography

2021 ◽  
Author(s):  
Byung Seok Moon ◽  
Hyun Soo Park ◽  
Jung Sunwoo ◽  
In‐Hyun Lee ◽  
Anhye Kim ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Oral Formulation ◽  
Emission Tomography ◽  
Tissue Pharmacokinetics ◽  
Positron Emission

Tissue pharmacokinetics of fleroxacin in humans as determined by positron emission tomography

1994 ◽  
Vol 4 ◽  
pp. S15-S20 ◽  
Author(s):  
Robert H. Rubin ◽  
E. Livni ◽  
John Babich ◽  
Nathaniel M. Alpert ◽  
Yu-Ying Liu ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Tissue Pharmacokinetics ◽  
Positron Emission

scholarly journals Pharmacokinetics of [18F]Trovafloxacin in Healthy Human Subjects Studied with Positron Emission Tomography

1998 ◽  
Vol 42 (8) ◽  
pp. 2048-2054 ◽  
Author(s):  
Alan J. Fischman ◽  
John W. Babich ◽  
Ali A. Bonab ◽  
Nathaniel M. Alpert ◽  
John Vincent ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Oral Dose ◽  
Human Subjects ◽  
Emission Tomography ◽  
Healthy Human ◽  
Tissue Pharmacokinetics ◽  
Positron Emission ◽  
Drug Concentrations ◽  
Common Causes ◽  
Complete Absorption

ABSTRACT Tissue pharmacokinetics of trovafloxacin, a new broad-spectrum fluoroquinolone antimicrobial agent, were measured by positron emission tomography (PET) with [18F]trovafloxacin in 16 healthy volunteers (12 men and 4 women). Each subject received a single oral dose of trovafloxacin (200 mg) daily beginning 5 to 8 days before the PET measurements. Approximately 2 h after the final oral dose, the subject was positioned in the gantry of the PET camera, and 1 h later 10 to 20 mCi of [18F]trovafloxacin was infused intravenously over 1 to 2 min. Serial PET images and blood samples were collected for 6 to 8 h, starting at the initiation of the infusion. Drug concentrations were expressed as the percentage of injected dose per gram, and absolute concentrations were estimated by assuming complete absorption of the final oral dose. In most tissues, there was rapid accumulation of the radiolabeled drug, with high levels achieved within 10 min after tracer infusion. Peak concentrations of more than five times the MIC at which 90% of the isolates are inhibited (MIC90) for most members ofEnterobacteriaceae and anaerobes (>10-fold for most organisms) were achieved in virtually all tissues, and the concentrations remained above this level for more than 6 to 8 h. Particularly high peak concentrations (micrograms per gram; mean ± standard error of the mean [SEM]) were achieved in the liver (35.06 ± 5.89), pancreas (32.36 ± 20.18), kidney (27.20 ± 10.68), lung (22.51 ± 7.11), and spleen (21.77 ± 11.33). Plateau concentrations (measured at 2 to 8 h; micrograms per gram; mean ± SEM) were 3.25 ± 0.43 in the myocardium, 7.23 ± 0.95 in the lung, 11.29 ± 0.75 in the liver, 9.50 ± 2.72 in the pancreas, 4.74 ± 0.54 in the spleen, 1.32 ± 0.09 in the bowel, 4.42 ± 0.32 in the kidney, 1.51 ± 0.15 in the bone, 2.46 ± 0.17 in the muscle, 4.94 ± 1.17 in the prostate, and 3.27 ± 0.49 in the uterus. In the brain, the concentrations (peak, ∼2.63 ± 1.49 μg/g; plateau, ∼0.91 ± 0.15 μg/g) exceeded the MIC90s for such common causes of central nervous system infections asStreptococcus pneumoniae (MIC90, <0.2 μg/ml), Neisseria meningitidis (MIC90, <0.008 μg/ml), and Haemophilus influenzae(MIC90, <0.03 μg/ml). These PET results suggest that trovafloxacin will be useful in the treatment of a broad range of infections at diverse anatomic sites.

Positron Emission Tomography of Cocaine Binding Sites on the Dopamine Transporter

1994 ◽  
Author(s):  
Bertha K. Madras ◽  
◽  
David R. Elmaleh ◽  
Peter C. Meltzer ◽  
Anna Y. Liung ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopamine Transporter ◽  
Binding Sites ◽  
Emission Tomography ◽  
Positron Emission
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