scholarly journals Clinical Pharmacology and Dosing Regimen Optimization of Neonatal Opioid Withdrawal Syndrome Treatments

2021 ◽  
Author(s):  
Fei Tang ◽  
Chee M. Ng ◽  
Henrietta S. Bada ◽  
Markos Leggas
Keyword(s):  
Clinical Pharmacology ◽  
Withdrawal Syndrome ◽  
Opioid Withdrawal ◽  
Dosing Regimen ◽  
Opioid Withdrawal Syndrome

scholarly journals Sex-Dependent Gene Expression in Infants with Neonatal Opioid Withdrawal Syndrome

2019 ◽  
Vol 214 ◽  
pp. 60-65.e2 ◽  
Author(s):  
Elizabeth Yen ◽  
Tomoko Kaneko-Tarui ◽  
Robin Ruthazer ◽  
Karen Harvey-Wilkes ◽  
Mona Hassaneen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Withdrawal Syndrome ◽  
Opioid Withdrawal ◽  
Opioid Withdrawal Syndrome

Maternal opioid use disorder: Placental transcriptome analysis for neonatal opioid withdrawal syndrome

Genomics ◽  
2021 ◽  
Author(s):  
Uppala Radhakrishna ◽  
Swapan K. Nath ◽  
Sangeetha Vishweswaraiah ◽  
Lavanya V. Uppala ◽  
Ariadna Forray ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Withdrawal Syndrome ◽  
Opioid Use Disorder ◽  
Opioid Withdrawal ◽  
Opioid Use ◽  
Opioid Withdrawal Syndrome

Neonatal Opioid Withdrawal Syndrome Is Associated With Infant Foster Care Entry At The County Level

2021 ◽  
Author(s):  
Sarah F. Loch ◽  
Bradley D. Stein ◽  
Robin Ghertner ◽  
Elizabeth McNeer ◽  
William D. Dupont ◽  
...  
Keyword(s):  
Foster Care ◽  
Withdrawal Syndrome ◽  
Opioid Withdrawal ◽  
County Level ◽  
Opioid Withdrawal Syndrome

scholarly journals Breastfeeding Intention Compared With Breastfeeding Postpartum Among Women Receiving Medication-Assisted Treatment

2018 ◽  
Vol 35 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Nicole Yonke ◽  
Rebekah Maston ◽  
Sherry Weitzen ◽  
Lawrence Leeman
Keyword(s):  
Pharmacological Treatment ◽  
Withdrawal Syndrome ◽  
Opioid Withdrawal ◽  
Hepatitis C Infection ◽  
Chi Square ◽  
Substance Abuse Treatment Program ◽  
Breastfed Infants ◽  
Polysubstance Use ◽  
Opioid Withdrawal Syndrome ◽  
Intention To Breastfeed

Background: Women taking methadone or buprenorphine are encouraged to breastfeed if stable without polysubstance use. Research Aim: We aimed to determine the difference between stated intention to breastfeed prenatally in women taking methadone or buprenorphine compared with breastfeeding at discharge and 2 months postpartum. Secondary outcomes were determining whether breastfeeding was more common in women taking buprenorphine, in women without hepatitis C infection, and in women without a history of heroin use, and whether breastfeeding reduced the need for pharmacological treatment of neonatal opioid withdrawal syndrome. Methods: This was a retrospective cohort study of 228 women enrolled in a perinatal substance abuse treatment program. Electronic medical records were reviewed to abstract data on mother-infant dyads. Chi-square tests were used to analyze our outcomes. Results: Women taking buprenorphine had a higher prevalence of breastfeeding compared with women taking methadone (83% [ n = 100] vs. 71% [ n = 76]; χ2 = 4.35, p = .03), despite no difference in their prenatal intention to breastfeed (87% vs. 81%; χ2 = 1.28, p = .25). Only 31% ( n = 38) of women taking buprenorphine and 19.6% ( n = 21) of women taking methadone exclusively breastfed at discharge (χ2 = 5.43, p = .06). Exclusively breastfed infants required less pharmacological treatment for neonatal opioid withdrawal syndrome compared with formula-fed infants (15.8% [ n = 21] vs. 47.4% [ n = 38]; χ2 = 19.72, p < .05). Conclusion: Despite most women reporting a high prenatal intention to breastfeed, exclusive breastfeeding at hospital discharge postpartum was low. Breastfeeding was associated with a decreased likelihood of pharmacological treatment for neonatal opioid withdrawal syndrome.

scholarly journals TH66. POLYGENIC PREDICTION OF RESPONSE TO PHARMACOTHERAPY IN INFANTS WITH NEONATAL OPIOID WITHDRAWAL SYNDROME

2021 ◽  
Vol 51 ◽  
pp. e229-e230
Author(s):  
Elizabeth Humphries ◽  
Daniel Smolyak ◽  
Abhinav Parikh ◽  
Ritu Agarwal ◽  
Margret Bjarnadottir ◽  
...  
Keyword(s):  
Withdrawal Syndrome ◽  
Opioid Withdrawal ◽  
Prediction Of Response ◽  
Opioid Withdrawal Syndrome
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