scholarly journals Correlation Analysis Among the Level of IL‐35, Microvessel Density, Lymphatic Vessel Density, and Prognosis in Non‐Small Cell Lung Cancer

2020 ◽  
Author(s):  
Tenglong Zhang ◽  
Jing Nie ◽  
Xiaojiang Liu ◽  
Zenglei Han ◽  
Ning Ding ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Correlation Analysis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Microvessel Density ◽  
Lymphatic Vessel ◽  
Small Cell ◽  
Vessel Density ◽  
Lymphatic Vessel Density ◽  
Small Cell Lung

Expression of Periostin in Patients with Non-Small Cell Lung Cancer: Correlation with Angiogenesis and Lymphangiogenesis

2008 ◽  
Vol 23 (3) ◽  
pp. 182-186 ◽  
Author(s):  
I. Takanami ◽  
T. Abiko ◽  
S. Koizumi
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Microvessel Density ◽  
Survival Rates ◽  
Additive Model ◽  
Small Cell ◽  
Disease Stage ◽  
Small Cell Lung ◽  
Lymphatic Microvessel Density

The aim of this study was to evaluate periostin expression measured immunohistochemically in patients with non-small cell lung cancer (NSCLC) and to determine its association with clinical features, prognosis, angiogenesis, and lymphangiogenesis. We investigated periostin expression in a series of 88 patients with NSCLC. We also determined whether expression of periostin correlated with microvessel density and lymphatic microvessel density. Periostin was expressed in 42% of 88 patients. Its expression was significantly correlated with tumor size, lymph node metastasis, disease stage, and lymphatic invasion (p=0.0128, 0.0015, 0.0310 and 0.0273, respectively). There also was a significant relation between periostin expression and microvessel density and lymphatic microvessel density (all p<0.0001). Five-year survival rates were better in patients with negative periostin expression than in those with positive periostin expression (p=0.0044). Periostin expression was not significant in a multivariate additive model. Our findings show that periostin correlates with increased tumor progression and a worse prognosis in NSCLC, as well as with angiogenesis and lymphangiogenesis.

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