scholarly journals Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin

2020 ◽  
Vol 13 (6) ◽  
pp. 1236-1243 ◽  
Author(s):  
Minna Lehtisalo ◽  
Jenni E. Keskitalo ◽  
Aleksi Tornio ◽  
Outi Lapatto‐Reiniluoto ◽  
Feng Deng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Resistance Protein ◽  
Plasma Concentrations ◽  
Cancer Resistance ◽  
Protein Substrate ◽  
Resistance Protein

Effect of excipients on breast cancer resistance protein substrate uptake activity

2007 ◽  
Vol 124 (1-2) ◽  
pp. 1-5 ◽  
Author(s):  
Tetsuo Yamagata ◽  
Hiroyuki Kusuhara ◽  
Mariko Morishita ◽  
Kozo Takayama ◽  
Hassan Benameur ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Resistance Protein ◽  
Substrate Uptake ◽  
Cancer Resistance ◽  
Protein Substrate ◽  
Uptake Activity ◽  
Resistance Protein

scholarly journals Differential Effects of Chrysin on Nitrofurantoin Pharmacokinetics Mediated by Intestinal Breast Cancer Resistance Protein in Rats and Mice

2009 ◽  
Vol 12 (2) ◽  
pp. 150 ◽  
Author(s):  
Atsushi Kawase ◽  
Yukako Matsumoto ◽  
Motoshi Hadano ◽  
Yui Ishii ◽  
Masahiro Iwaki
Keyword(s):  
Breast Cancer ◽  
Small Intestine ◽  
Breast Cancer Resistance Protein ◽  
Plasma Concentrations ◽  
Mrna Levels ◽  
Cancer Resistance ◽  
Glycoprotein P ◽  
Metabolizing Enzymes ◽  
Resistance Protein ◽  
Rats And Mice

PURPOSE: The activities of breast cancer resistance protein (Bcrp/ABCG2) as well as P-glycoprotein (P-gp) and drug-metabolizing enzymes can be inhibited by several flavonoids or drugs in rats. However, the species, gender and regional differences of effects of flavonoids on Bcrp/ABCG2 in rats and mice remain unclear, although Bcrp, like P-gp, is also important in controlling drug absorption and disposition. METHODS: We used chrysin as a model flavonoid because it possesses anti-inflammatory and antioxidative properties and is used as a dietary supplement. We examined the pharmacokinetics of nitrofurantoin, a specific Bcrp substrate, in rats and mice treated with chrysin. Bcrp mRNA levels were measured in liver, kidney, duodenum, jejunum and ileum in rats and mice. RESULTS: Plasma concentrations of nitrofurantoin were increased in rats, but not mice, treated with oral chrysin, compared with untreated controls. Intraperitoneal injection of chrysin into rats or mice had little effect on the elimination of nitrofurantoin, compared with untreated animals. CONCLUSIONS: These results suggest that chrysin-nitrofurantoin interactions occur in the small intestine in rats, but not in mice, possibly due to the higher levels of Bcrp expression in the small intestine in rats, compared with those in mice.

Breast Cancer Resistance Protein Substrate and Inhibition Evaluation: Why, When, and How?

2014 ◽  
Vol 42 (12) ◽  
pp. 1979-1980 ◽  
Author(s):  
Joseph A. Ware ◽  
Bradley L. Urquhart ◽  
Yuichi Sugiyama ◽  
Maciej J. Zamek-Gliszczynski
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Resistance Protein ◽  
Cancer Resistance ◽  
Protein Substrate ◽  
Resistance Protein
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