scholarly journals Training the Translational Research Teams of the Future: UC Davis-HHMI Integrating Medicine into Basic Science Program

2013 ◽  
Vol 6 (5) ◽  
pp. 339-346 ◽  
Author(s):  
Anne A. Knowlton ◽  
Julie A. Rainwater ◽  
Nipavan Chiamvimonvat ◽  
Ann C. Bonham ◽  
John A. Robbins ◽  
...  
Keyword(s):  
Translational Research ◽  
Basic Science ◽  
Science Program ◽  
Research Teams ◽  
The Future

scholarly journals Evaluating student performance in a decentralized basic science program

1976 ◽  
Vol 51 (6) ◽  
pp. 473-7
Author(s):  
T J Cullen ◽  
C W Dohner ◽  
G E Striker ◽  
M R Schwarz
Keyword(s):  
Student Performance ◽  
Basic Science ◽  
Science Program

Looking Forward in Geriatric Anxiety and Depression: Implications of Basic Science for the Future

2005 ◽  
Vol 13 (12) ◽  
pp. 1027-1040 ◽  
Author(s):  
Howard K. Gershenfeld ◽  
Robert A. Philibert ◽  
Gary W. Boehm
Keyword(s):  
Basic Science ◽  
Anxiety And Depression ◽  
The Future

The Basic Science of Lateral Epicondylosis: Update for the Future

2006 ◽  
Vol 21 (4) ◽  
pp. 250-255 ◽  
Author(s):  
Shariff K. Bishai ◽  
Kevin D. Plancher
Keyword(s):  
Basic Science ◽  
The Future ◽  
Lateral Epicondylosis

scholarly journals The Future of Restorative Neurosciences in Stroke: Driving the Translational Research Pipeline From Basic Science to Rehabilitation of People After Stroke

2008 ◽  
Vol 23 (2) ◽  
pp. 97-107 ◽  
Author(s):  
◽  
Binith Cheeran ◽  
Leonardo Cohen ◽  
Bruce Dobkin ◽  
Gary Ford ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Translational Research ◽  
Basic Science ◽  
Clinical Importance ◽  
Small Scale ◽  
Front Line ◽  
Pressure Groups ◽  
The United Kingdom ◽  
Public Sector Research

Background. Major advances during the past 50 years highlight the immense potential for restoration of function after neural injury, even in the damaged adult human brain. Yet, the translation of these advances into clinically useful treatments is painstakingly slow. Objective. Here, we consider why the traditional model of a “translational research pipeline” that transforms basic science into novel clinical practice has failed to improve rehabilitation practice for people after stroke. Results. We find that (1) most treatments trialed in vitro and in animal models have not yet resulted in obviously useful functional gains in patients; (2) most clinical trials of restorative treatments after stroke have been limited to small-scale studies; (3) patient recruitment for larger clinical trials is difficult; (4) the determinants of patient outcomes and what patients want remain complex and ill-defined, so that basic scientists have no clear view of the clinical importance of the problems that they are addressing; (5) research in academic neuroscience centers is poorly integrated with practice in front-line hospitals and the community, where the majority of patients are treated; and (6) partnership with both industry stakeholders and patient pressure groups is poorly developed, at least in the United Kingdom where research in the translational restorative neurosciences in stroke depends on public sector research funds and private charities. Conclusions. We argue that interaction between patients, front-line clinicians, and clinical and basic scientists is essential so that they can explore their different priorities, skills, and concerns. These interactions can be facilitated by funding research consortia that include basic and clinical scientists, clinicians and patient/carer representatives with funds targeted at those impairments that are major determinants of patient and carer outcomes. Consortia would be instrumental in developing a lexicon of common methods, standardized outcome measures, data sharing and long-term goals. Interactions of this sort would create a research-friendly, rather than only target-led, culture in front-line stroke rehabilitation services.

Basic Principles of Translational Research

2012 ◽  
Author(s):  
Boris Rubinsky
Keyword(s):  
Translational Research ◽  
Basic Concept ◽  
Basic Science ◽  
Clinical Medicine ◽  
Irreversible Electroporation ◽  
The Public ◽  
Food Engineering ◽  
New Science ◽  
Fda Approval ◽  
Health Laws

Translational research turns fundamental new science and innovations into a product that has value to the public. The process is difficult because it combines a variety of diverse disciplines and skills from basic science, clinical medicine, engineering, business, public health, laws and regulations. These areas are so wide apart that it is very difficult to combine. The author has engaged in translational research since the early 1980’s and will describe the processes, pitfalls and rewards through typical examples from his projects that include: development of imaging monitored cryosurgery from concept to treatment of hundreds of thousands of patients, transgenes in food engineering from basic science to a twenty year wait for FDA approval, microelectroporation from basic concept to incorporation of the technology by numerous companies and non-thermal irreversible electroporation from basic concept to current clinical use in over 50 hospitals and over thousand treated patients.

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