Race does not predict pancreas graft failure after pancreas transplantation in the Modern Era

2021 ◽  
Author(s):  
Zhiwei Li ◽  
Jie Xiang ◽  
Jianhua Liu ◽  
Li Wang
Keyword(s):  
Pancreas Transplantation ◽  
Graft Failure ◽  
Modern Era ◽  
Pancreas Graft

Race Does Not Predict Pancreas Graft Failure after Pancreas Transplantation in Modern Era

2020 ◽  
Author(s):  
Zhiwei Li ◽  
Zheng Chen ◽  
Zhichao Huang ◽  
Jie Xiang ◽  
Jie Zhou ◽  
...  
Keyword(s):  
Pancreas Transplantation ◽  
Graft Failure ◽  
Modern Era ◽  
Pancreas Graft

Long-term Effects of Delayed Graft Function on Pancreas Graft Survival After Pancreas Transplantation

2014 ◽  
Vol 98 (12) ◽  
pp. 1316-1322 ◽  
Author(s):  
Sung Shin ◽  
Duck Jong Han ◽  
Young Hoon Kim ◽  
Seungbong Han ◽  
Byung Hyun Choi ◽  
...  
Keyword(s):  
Graft Survival ◽  
Pancreas Transplantation ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Long Term Effects ◽  
Pancreas Graft

What We Do and Donʼt Understand About Pancreas Graft Failure.

2014 ◽  
Vol 98 ◽  
pp. 863
Author(s):  
R. Stratta ◽  
A. Farney ◽  
G. Orlando ◽  
U. Farooq ◽  
Y. Al-Shraideh ◽  
...  
Keyword(s):  
Graft Failure ◽  
Pancreas Graft

One-Year Blood Glucose Level is the Best Metabolic Marker for the Prediction of Late Pancreas Graft Failure

2018 ◽  
Vol 102 ◽  
pp. S77
Author(s):  
Marine Ollivier ◽  
Lucy L.C. Chaillous ◽  
Bertrand B.C. Cariou ◽  
George G.K. Karam ◽  
Julien J.B. Branchereau ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Graft Failure ◽  
Metabolic Marker ◽  
One Year ◽  
Pancreas Graft

Tu1378 - Incidence of Pancreatitis and Graft Failure Resulting from Pancreatitis after Pancreas Transplantation: A Descriptive Study using UNOS Database

2018 ◽  
Vol 154 (6) ◽  
pp. S-948
Author(s):  
Avanija Buddam ◽  
Ryan W. Walters ◽  
Thamer Kassim ◽  
Sandeep Mukherjee ◽  
Renuga Vivekanandan
Keyword(s):  
Pancreas Transplantation ◽  
Graft Failure ◽  
Descriptive Study

scholarly journals SUN-624 Low Risk of Major Adverse Cardiovascular Events After Pancreas Transplantation Alone

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Ravinder Jeet Kaur ◽  
Byron H Smith ◽  
Shafaq R Rizvi ◽  
Sreedhar Batthula ◽  
Aleksandra Kukla ◽  
...  
Keyword(s):  
Cardiovascular Events ◽  
Pancreas Transplantation ◽  
Graft Failure ◽  
Event Rate ◽  
Major Adverse Cardiovascular Events ◽  
C Peptide ◽  
Duration Of Diabetes ◽  
Post Transplant ◽  
Increased Risk

Abstract INTRODUCTION: Type 1 Diabetes (T1D) patients have an increased risk for major adverse cardiovascular events (MACE). Pancreas Transplantation Alone (PTA) in patients with T1D achieves near normal glucose control for a prolonged period but limited data are available to date regarding MACE during a 10 year follow up period after the procedure. OBJECTIVE: We studied incidence of MACE after PTA in T1D patients over a 10 year follow-up period. METHODS: Retrospectively, we studied 113 T1D recipients of PTA at Mayo Clinic, Rochester with the procedure performed between January 1998 and August 2018 and follow up of at least 1 year. Data were collected before transplantation and up to 10 year follow up after the first PTA. MACE data were gathered until primary non function, re-transplantation, or complete loss of c-peptide (<0.01ng/ml). We report vascular risk factors including hypertension, hyperlipidemia, smoking and BMI along with MACE (defined as cardiac events as unstable angina, Myocardial Infarction (MI), need for re-vascularization, cardiac death, cerebral events as Transient ischemic attack (TIA), stroke, need for re-vascularization and peripheral arterial disease as need for re-vascularization, gangrene and amputation). RESULTS: Eighteen subjects had pre-transplant MACE. A total of 14 subjects had graft failure within 24 to 36 hours due to thrombosis, with 3 in pre-transplant MACE cohort and 11 in no MACE cohort. Thus, we followed 99 subjects for the development of post-transplant MACE for a period of 6.3 ± 3.6 years. T1D subjects with MACE (n=15) had baseline characteristics: Age 48± 7.8 years, gender F/M 9/6,, duration of diabetes 33 ± 12 years, BMI 26± 3.1(Kg/m2), HbA1c 9.3 ± 1.5% and C-peptide 0.09 ng/ml. 84 T1D patients without MACE were age 42 ± 10.6 years, gender F/M 55/29, duration of diabetes 26.5 ± 10.7 years, BMI 26 ± 5.2(Kg/m2), HbA1c 6.7 ± 2.5 and C-peptide 0.09 ng/ml. There are a total of 584 person-years of follow up to first MACE event and 632 person-years of graft failure, death or last follow-up. Nine patients developed 11 MACE events post-PTA. Therefore, the event rate is 1.5 MACE events per 100 person-years for first MACE event and the total event rate is 1.7 MACE events per 100 person-years of follow-up. Age, smoking (yes), gender, duration of diabetes, HTN and Hyperlipidemia presence did not show any significant impact on post-transplant MACE outcome based on univariate Cox regression but the pre-transplant BMI (HR = 1.14; CI = (1.04, 1.26); p = 0.008) and pre-transplant HbA1c (HR = 1.26; CI = (1.06, 1.51); p = 0.01) showed statistically significant impact. CONCLUSIONS: At our center, MACE is low in PTA recipients. There is no impact of presence of pre-transplant MACE on development of post-transplant MACE but pre-transplant BMI and HbA1c account for risk of MACE.

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