Donor factors and risk of primary graft dysfunction and mortality post lung transplantation – A proposed conceptual framework

2021 ◽  
Author(s):  
Mrinalini Venkata‐Subramani ◽  
David R. Nunley ◽  
Jesse Roman
Keyword(s):  
Lung Transplantation ◽  
Conceptual Framework ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Donor Factors

scholarly journals Recent advances in lung transplantation

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1684 ◽  
Author(s):  
Keith C Meyer
Keyword(s):  
Lung Transplantation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Donor Pool ◽  
Post Transplant ◽  
Antibody Mediated Rejection ◽  
The Past ◽  
End Stage ◽  
Transplant Complications

Lung transplantation can improve quality of life and prolong survival for individuals with end-stage lung disease, and many advances in the realms of both basic science and clinical research aspects of lung transplantation have emerged over the past few decades. However, many challenges must yet be overcome to increase post-transplant survival. These include successfully bridging patients to transplant, expanding the lung donor pool, inducing tolerance, and preventing a myriad of post-transplant complications that include primary graft dysfunction, forms of cellular and antibody-mediated rejection, chronic lung allograft dysfunction, and infections. The goal of this manuscript is to review salient recent and evolving advances in the field of lung transplantation.

scholarly journals Integrative analysis correlates donor transcripts to recipient autoantibodies in primary graft dysfunction after lung transplantation

Immunology ◽  
2010 ◽  
Vol 132 (3) ◽  
pp. 394-400 ◽  
Author(s):  
Peter H. Hagedorn ◽  
Christopher M. Burton ◽  
Eli Sahar ◽  
Eytan Domany ◽  
Irun R. Cohen ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Integrative Analysis ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction

Primary graft dysfunction after lung transplantation

2012 ◽  
Vol 36 (7) ◽  
pp. 506-512
Author(s):  
V.J. Suárez López ◽  
E. Miñambres ◽  
J.C. Robles Arista ◽  
M.A. Ballesteros
Keyword(s):  
Lung Transplantation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction

Impact of Anastomosis Time during Lung Transplantation on Primary Graft Dysfunction

2022 ◽  
Author(s):  
Christelle M. Vandervelde ◽  
Robin Vos ◽  
Cedric Vanluyten ◽  
Steffen Fieuws ◽  
Stijn E. Verleden ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction

scholarly journals Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation

Thorax ◽  
2018 ◽  
Vol 74 (4) ◽  
pp. 413-416 ◽  
Author(s):  
Peter S Cunningham ◽  
Robert Maidstone ◽  
Hannah J Durrington ◽  
Rajamayier V Venkateswaran ◽  
Marcelo Cypel ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Lung Transplantation ◽  
Organ Preservation ◽  
Retrospective Cohort ◽  
Circadian Regulation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Donor Lung ◽  
Retrospective Cohort Studies ◽  
Clock Protein

The importance of circadian factors in managing patients is poorly understood. We present two retrospective cohort studies showing that lungs reperfused between 4 and 8 AM have a higher incidence (OR 1.12; 95% CI 1.03 to 1.21; p=0.01) of primary graft dysfunction (PGD) in the first 72 hours after transplantation. Cooling of the donor lung, occurring during organ preservation, shifts the donor circadian clock causing desynchrony with the recipient. The clock protein REV-ERBα directly regulates PGD biomarkers explaining this circadian regulation while also allowing them to be manipulated with synthetic REV-ERB ligands.

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