Exercise‐based rehabilitation strategies in heart transplant recipients: Focus on high‐intensity interval training

2020 ◽  
Author(s):  
Daniele Masarone ◽  
Enrico Melillo ◽  
Andrea Petraio ◽  
Fabio Valente ◽  
Rita Gravino ◽  
...  
Keyword(s):  
Heart Transplant ◽  
High Intensity ◽  
Interval Training ◽  
Transplant Recipients ◽  
High Intensity Interval Training ◽  
Heart Transplant Recipients ◽  
High Intensity Interval ◽  
Rehabilitation Strategies

scholarly journals Effect of high-intensity interval training in young heart transplant recipients: results from two randomized controlled trials

2020 ◽  
Author(s):  
Kari Nytrøen ◽  
Katrine Rolid ◽  
Marianne Yardley ◽  
Lars Gullestad
Keyword(s):  
Randomized Controlled Trials ◽  
Heart Transplant ◽  
High Intensity ◽  
Interval Training ◽  
Controlled Trials ◽  
Transplant Recipients ◽  
High Intensity Interval Training ◽  
Randomized Controlled ◽  
Heart Transplant Recipients ◽  
High Intensity Interval

Abstract Background Little is known about the effect of exercise in young heart transplant recipients, and results on group level is lacking. This study summarizes the findings of the youngest participants in two previous randomized controlled trials. Method This is a hypothesis-generating study reporting the main results from the youngest participants in two larger randomized controlled trials investigating the effect of high-intensity interval training (HIT). The article summarizes the main results from 28 young participants (< 40 year of age) who have participated in two previous studies which evaluated the effect of HIT vs. controls in adult heart transplant recipients. One of the studies included de novo heart transplant recipients and the other included maintenance heart transplant recipients. All study tests were performed in-hospital, in the specialist health care setting, but the exercise intervention was carried out locally, in cooperation with the primary health care. In both studies the exercise intervention lasted for 9-12 months. In one study, HIT (85%-95% of peak effort) was compared to controls (no specific intervention), and in the other study HIT was compared to moderate, continuous exercise (MICT, 60-70% of peak effort). The main outcome measure was peak oxygen uptake (VO2peak) and a secondary endpoint was muscle strength. Results The summarized findings from the youngest heart transplant recipients in these two studies demonstrated mainly that the improvement in peak oxygen uptake among the younger recipients (< 40 years) was much larger (4.7 vs. 1.2 ml/kg/min and 7.0 vs. 2.2 ml/kg/min) compared to the improvement among the older recipients (≥ 40 years), and in accordance with results from adult heart transplant populations: HIT, compared to MICT, induced the largest improvement in peak oxygen consumption, also in the younger heart transplant recipients. Conclusions These results suggest that young heart transplant recipients have a greater effect of HIT than of MICT and may also suggest that younger recipients benefit more from high-intensity interval training than their older co-patients. However, larger randomized studies focusing on the young heart transplant population is strongly needed to confirm this hypothesis.

scholarly journals Effect of High-Intensity Interval Training in De Novo Heart Transplant Recipients in Scandinavia

Circulation ◽  
2019 ◽  
Vol 139 (19) ◽  
pp. 2198-2211 ◽  
Author(s):  
Kari Nytrøen ◽  
Katrine Rolid ◽  
Arne Kristian Andreassen ◽  
Marianne Yardley ◽  
Einar Gude ◽  
...  
Keyword(s):  
Heart Transplant ◽  
High Intensity ◽  
De Novo ◽  
Interval Training ◽  
Transplant Recipients ◽  
High Intensity Interval Training ◽  
Heart Transplant Recipients ◽  
High Intensity Interval

scholarly journals Effect of high-intensity interval training in young heart transplant recipients: results from two randomized controlled trials

2019 ◽  
Author(s):  
Kari Nytrøen ◽  
Katrine Rolid ◽  
Marianne Yardley ◽  
Lars Gullestad
Keyword(s):  
Heart Transplant ◽  
High Intensity ◽  
Exercise Intervention ◽  
Interval Training ◽  
Peak Oxygen Uptake ◽  
Transplant Recipients ◽  
High Intensity Interval Training ◽  
Randomized Controlled ◽  
Heart Transplant Recipients ◽  
High Intensity Interval

Abstract Background Little is known about the effect of exercise in young heart transplant recipients, and results on group level is lacking. This study summarizes the findings of the youngest participants in two previous randomized controlled trials.Method This is a hypothesis-generating study reporting the main results from the youngest participants in two larger randomized controlled trials investigating the effect of high-intensity interval training (HIT). The article summarizes the main results from 28 young participants (< 40 year of age) who have participated in two previous studies which evaluated the effect of HIT vs. controls in adult heart transplant recipients. One of the studies included de novo heart transplant recipients and the other included maintenance heart transplant recipients. All study tests were performed in-hospital, in the specialist health care setting, but the exercise intervention was carried out locally, in cooperation with the primary health care. In both studies the exercise intervention lasted for 9-12 months. In one study, HIT was compared to controls (no specific intervention), and in the other study HIT was compared to moderate, continuous exercise (MICT). The main outcome measure was peak oxygen uptake (VO 2peak ).Results The summarized findings from the youngest heart transplant recipients in these two studies demonstrated mainly that the improvement in peak oxygen uptake among the younger recipients (< 40 years) was much larger compared to the improvement among the older recipients (≥ 40 years), and in accordance with results from adult heart transplant populations: HIT, compared to MICT, induced the largest improvement in peak oxygen consumption, also in the younger heart transplant recipients.Conclusions This result may suggest that younger recipients benefit more from high-intensity interval training than their older co-patients. However, larger randomized studies focusing on the young heart transplant population is strongly needed to confirm this hypothesis.

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