Efficacy and safety of febuxostat for treatment of asymptomatic hyperuricemia among kidney transplant patients: A meta‐analysis of observational studies

2020 ◽  
Vol 34 (4) ◽  
Author(s):  
Api Chewcharat ◽  
Yuan‐Ting Chang ◽  
Charat Thongprayoon ◽  
Anthony Crisafio ◽  
Tarun Bathini ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Observational Studies ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Efficacy and Safety of SGLT-2 Inhibitors for Treatment of Diabetes Mellitus among Kidney Transplant Patients: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 8 (4) ◽  
pp. 47
Author(s):  
Api Chewcharat ◽  
Narut Prasitlumkum ◽  
Charat Thongprayoon ◽  
Tarun Bathini ◽  
Juan Medaura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Blood Pressure ◽  
Body Weight ◽  
Kidney Transplant ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Transplant Patients ◽  
Treatment Of Diabetes ◽  
Kidney Transplant Patients

Background: The objective of this systematic review was to evaluate the efficacy and safety profiles of sodium-glucose co-transporter 2 (SGLT-2) inhibitors for treatment of diabetes mellitus (DM) among kidney transplant patients. Methods: We conducted electronic searches in Medline, Embase, Scopus, and Cochrane databases from inception through April 2020 to identify studies that investigated the efficacy and safety of SGLT-2 inhibitors in kidney transplant patients with DM. Study results were pooled and analyzed utilizing random-effects model. Results: Eight studies with 132 patients (baseline estimated glomerular filtration rate (eGFR) of 64.5 ± 19.9 mL/min/1.73 m2) treated with SGLT-2 inhibitors were included in our meta-analysis. SGLT-2 inhibitors demonstrated significantly lower hemoglobin A1c (HbA1c) (WMD = −0.56% [95%CI: −0.97, −0.16]; p = 0.007) and body weight (WMD = −2.16 kg [95%CI: −3.08, −1.24]; p < 0.001) at end of study compared to baseline level. There were no significant changes in eGFR, serum creatinine, urine protein creatinine ratio, and blood pressure. By subgroup analysis, empagliflozin demonstrated a significant reduction in body mass index (BMI) and body weight. Canagliflozin revealed a significant decrease in HbA1C and systolic blood pressure. In terms of safety profiles, fourteen patients had urinary tract infection. Only one had genital mycosis, one had acute kidney injury, and one had cellulitis. There were no reported cases of euglycemic ketoacidosis or acute rejection during the treatment. Conclusion: Among kidney transplant patients with excellent kidney function, SGLT-2 inhibitors for treatment of DM are effective in lowering HbA1C, reducing body weight, and preserving kidney function without reporting of serious adverse events, including euglycemic ketoacidosis and acute rejection.

Efficacy and Safety of Eculizumab in Kidney Transplant Patients With Primary Atypical Hemolytic-Uremic Syndrome

2021 ◽  
Author(s):  
Cristina Casas González ◽  
Verónica López-Jiménez ◽  
Teresa Vázquez-Sánchez ◽  
Elena Vázquez-Sánchez ◽  
Mercedes Cabello ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Kidney Transplant ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Efficacy And Safety ◽  
Transplant Patients ◽  
Uremic Syndrome ◽  
Kidney Transplant Patients

Effect of Fluvastatin on Cardiovascular Complications in Kidney Transplant Patients: A Systemic Review and Meta-analysis

2019 ◽  
Vol 51 (8) ◽  
pp. 2710-2713 ◽  
Author(s):  
Seun Deuk Hwang ◽  
Jin Ho Lee ◽  
Jong Hyun Jhee ◽  
Yoon Ji Kim ◽  
Keun-Myoung Park ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Meta Analysis ◽  
Cardiovascular Complications ◽  
Systemic Review ◽  
Transplant Patients ◽  
Kidney Transplant Patients

The clinical impacts of sleep apnea on mortality and allograft function in kidney transplant patients: A meta-analysis

2020 ◽  
Author(s):  
Panupong Hansrivijit ◽  
Tejaswi Kanderi ◽  
Max M. Puthenpura ◽  
Nasrollah Ghahramani ◽  
Charat Thongprayoon ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Kidney Transplant ◽  
Meta Analysis ◽  
Transplant Patients ◽  
Allograft Function ◽  
Kidney Transplant Patients
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