scholarly journals Deceased organ donor factors influencing pancreatic graft transplantation and survival

2019 ◽  
Vol 33 (6) ◽  
Author(s):  
Mitchell B. Sally ◽  
Margaret Katherine Ellis ◽  
Michael Hutchens ◽  
Tahnee Groat ◽  
Elizabeth Swanson ◽  
...  
Keyword(s):  
Organ Donor ◽  
Factors Influencing ◽  
Donor Factors ◽  
Pancreatic Graft

The influence of organ donor factors on early allograft function

2003 ◽  
Vol 13 (2) ◽  
pp. 99-104 ◽  
Author(s):  
Christoph Schwarz ◽  
Rainer Oberbauer
Keyword(s):  
Organ Donor ◽  
Allograft Function ◽  
Donor Factors

Effects of Organ Donor Factors on Lung Transplant Recipient Outcome at One-Year Follow-Up

2014 ◽  
Vol 33 (4) ◽  
pp. S269-S270
Author(s):  
H. Auråen ◽  
A.E. Fiane ◽  
Ø. Bjørtuft ◽  
U. Christen ◽  
O. Geiran ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Lung Transplant ◽  
Organ Donor ◽  
Lung Transplant Recipient ◽  
Donor Factors ◽  
One Year

Donor Factors Influencing Graft Outcomes in Live Donor Kidney Transplantation

2007 ◽  
Vol 83 (5) ◽  
pp. 593-599 ◽  
Author(s):  
Naim Issa ◽  
Brian Stephany ◽  
Richard Fatica ◽  
Saul Nurko ◽  
Venkatesh Krishnamurthi ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Live Donor ◽  
Donor Kidney ◽  
Live Donor Kidney Transplantation ◽  
Factors Influencing ◽  
Live Donor Kidney ◽  
Donor Factors ◽  
Donor Kidney Transplantation

Donor factors influencing corneal tissue utilization in North India

2018 ◽  
Vol 10 (2) ◽  
pp. 44
Author(s):  
Anuradha Raj ◽  
Garima Mittal ◽  
Harsh Bahadur
Keyword(s):  
North India ◽  
Corneal Tissue ◽  
Factors Influencing ◽  
Donor Factors

scholarly journals Widerspruchslösung – ein Weg zu höheren Organspenderaten?

2018 ◽  
Vol 87 (2) ◽  
pp. 153-168
Author(s):  
Eberling Elisabeth
Keyword(s):  
The Netherlands ◽  
Organ Donation ◽  
Organ Donor ◽  
Mortality Rates ◽  
Legal Regulation ◽  
Presumed Consent ◽  
Factors Influencing ◽  
Gesetzliche Regelung ◽  
Deutsche Stiftung Organtransplantation ◽  
Default Setting

Zusammenfassung: In Deutschland sterben im Durchschnitt pro Tag drei Menschen, die vergeblich auf eine Organspende warten, so die Deutsche Stiftung Organtransplantation. In diesem Beitrag wird die Wirksamkeit eines Nudges mit der Einstellung des Defaults „Organe werden gespendet“ (Widerspruchslösung) diskutiert. Nachgegangen wird der Frage, ob dieser Nudge zu signifikant höheren Organspenderaten führt als der Default „Organe werden nicht gespendet“ anhand von Daten der acht Mitgliedsländer der Organisation Eurotransplant. Anhand der Analysen kann ausgeschlossen werden, dass eine höhere Organspenderate lediglich auf eine höhere Sterberate zurückzuführen ist. Separat vorgestellt werden zudem Ergebnisse für die Länder Deutschland, Niederlande, Belgien und Österreich. Diese Länder weisen ähnliche sozioökonomische Merkmale auf. Erörtert werden Einflussfaktoren auf die Organspenderaten und mögliche Probleme und Verzerrungen der Raten. Darüber hinaus wird diskutiert, inwiefern ein Nudge im Bereich der Organspende ethisch zu legitimieren ist. Das Ergebnis der Analysen: In Ländern mit Widerspruchsregelung ist die Organspenderate signifikant höher als in Ländern ohne entsprechende Regelung; die gesetzliche Regelung ist aber nicht eindeutig als Ursache isolierbar. Summary: According to the German Foundation for Organ Transplantation, on average, three people die each day in Germany while waiting for an organ donation. This article discusses the effectiveness of a nudge to the default setting “organs are donated” (presumed consent). It is explored whether this nudge leads to significantly higher organ donation rates than the default setting “organs are not donated“ based on data from the eight member countries of the Eurotransplant organization. The analysis shows that higher organ donation rates are not driven by higher mortality rates alone. The results for Germany, the Netherlands, Belgium and Austria are presented separately. These countries share similar socio-economic characteristics. Factors influencing organ donor rates are discussed as are possible problems and distortions of the donation rates. In addition, it is discussed to what extent a nudge in the field of organ donation can be ethically legitimized. The analyses show that, in countries with presumed consent, organ donation rates are significantly higher than in countries without this rule. However, it was not possible to identify the legal regulation as the sole cause of this difference.

Longer Procedure Duration and Large Volume Harvests Reduce the Likelihood of Achieving the Requested Cell Dose from Unrelated Bone Marrow Donors

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 2449-2449
Author(s):  
Chloe Anthias ◽  
Rebecca Arkwright ◽  
Annelies Billen ◽  
J. Alejandro Madrigal ◽  
Bronwen E. Shaw
Keyword(s):  
Bone Marrow ◽  
Large Volume ◽  
Significant Variation ◽  
Conflicts Of Interest ◽  
Related Factors ◽  
Peripheral Blood Stem Cells ◽  
Factors Influencing ◽  
Chi Squared ◽  
Donor Factors

Abstract Introduction The factors influencing the quality of bone marrow (BM) harvests and total nucleated cell count (TNC) achieved are poorly understood. As the number of BM harvest procedures falls (due to an increasing proportion of harvest requests for peripheral blood stem cells), concerns are raised around maintaining expertise in this area. We investigate, in four Anthony Nolan collection centers, the procedure- and donor -related factors influencing the quality of harvests, and likelihood of achieving the requested TNC. Materials & Method 110 consecutive BM harvests of healthy unrelated donors (UD)s were performed according to standard Anthony Nolan protocols. Harvest quality was defined as TNC/ml volume collected. Univariate analyses of factors influencing the TNC and harvest quality were performed using Chi squared or Fisher’s test where appropriate. Results 110 BM harvests were performed in 80 male and 30 female donors. The median donor age was 28 years (range 18-56 years). The median TNC requested was 4x108/kg, and median harvested TNC 4.2x108/kg recipient weight, with the requested TNC dose achieved in 50% of harvests. Higher volume harvests (greater than the median volume 1200 mls) were significantly less likely to achieve TNC> 4x108/kg recipient weight (38% vs 70% p=0.001), as were harvests with a procedure time greater than 30 minutes (p=0.037). We investigated donor factors influencing the harvest yield and found that donor/recipient weight discrepancy significantly impacted the TNC achieved: with only 18% of BM harvests from donors who weighed less than their recipient achieving TNC >4x108/kg compared to 62% harvests from donors who were heavier than their recipient (p=0.001). No other donor factor had a significant influence on the TNC. The median TNC/ml collected was 18.2x10^6/ml and harvests in donors>40 years were more likely to be of lower quality (p=0.036). No other donor factors affected harvest quality, however a significant variation between the 4 collection centers was observed: both the harvest quality (p=0.014) and volume collected (p=0.035) varied significantly between centers. Conclusions Donor weight is a strong determinant of bone marrow harvest yield; we recommend that when multiple matched UDs are available, a donor with high body weight should be selected for BM harvest. Procedure factors including large volume harvests and long procedure times reduce the likelihood of achieving the requested TNC, and significant variation was seen between centers. Given the declining number of requests for BM harvests, it is crucial these are performed by the most experienced centers and that systems exist to ensure operators retain their expertise. Disclosures No relevant conflicts of interest to declare.

Factors influencing adhesive bonding at the bone/implant interface

1992 ◽  
Vol 50 (2) ◽  
pp. 1114-1115
Author(s):  
Julie A. Martini ◽  
Robert H. Doremus
Keyword(s):  
Electron Microscopy ◽  
Adhesive Bonding ◽  
Microscopy Study ◽  
Electron Microscopy Study ◽  
Bone Implant ◽  
Factors Influencing ◽  
Lr White ◽  
Transmission Electron ◽  
New Zealand White Rabbits ◽  
Scanning Electron

Tracy and Doremus have demonstrated chemical bonding between bone and hydroxylapatite with transmission electron microscopy. Now researchers ponder how to improve upon this bond in turn improving the life expectancy and biocompatibility of implantable orthopedic devices.This report focuses on a study of the- chemical influences on the interfacial integrity and strength. Pure hydroxylapatite (HAP), magnesium doped HAP, strontium doped HAP, bioglass and medical grade titanium cylinders were implanted into the tibial cortices of New Zealand white rabbits. After 12 weeks, the implants were retrieved for a scanning electron microscopy study coupled with energy dispersive spectroscopy.Following sacrifice and careful retrieval, the samples were dehydrated through a graduated series starting with 50% ethanol and continuing through 60, 70, 80, 90, 95, and 100% ethanol over a period of two days. The samples were embedded in LR White. Again a graduated series was used with solutions of 50, 75 and 100% LR White diluted in ethanol.

Factors Influencing Electrophysiologic Responsivity in Normal Adults

1965 ◽  
Vol 8 (4) ◽  
pp. 323-347
Author(s):  
Robert Goldstein ◽  
Benjamin RosenblÜt
Keyword(s):  
Conditioned Stimulus ◽  
White Light ◽  
Pure Tone ◽  
Alpha Rhythm ◽  
White Women ◽  
White Men ◽  
Inverse Relation ◽  
Factors Influencing ◽  
Electrodermal Responses ◽  
Normal Adults

Electrodermal and electroencephalic responsivity to sound and to light was studied in 96 normal-hearing adults in three separate sessions. The subjects were subdivided into equal groups of white men, white women, colored men, and colored women. A 1 000 cps pure tone was the conditioned stimulus in two sessions and white light was used in a third session. Heat was the unconditioned stimulus in all sessions. Previously, an inverse relation had been found in white men between the prominence of alpha rhythm in the EEG and the ease with which electrodermal responses could be elicited. This relation did not hold true for white women. The main purpose of the present study was to answer the following questions: (1) are the previous findings on white subjects applicable to colored subjects? (2) are subjects who are most (or least) responsive electrophysiologically on one day equally responsive (or unresponsive) on another day? and (3) are subjects who are most (or least) responsive to sound equally responsive (or unresponsive) to light? In general, each question was answered affirmatively. Other factors influencing responsivity were also studied.

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