Urinary angiotensinogen level is increased in renal transplant recipients with masked hypertension and is correlated with left ventricular mass index and albuminuria in these patients

2018 ◽  
Vol 32 (9) ◽  
pp. e13375 ◽  
Author(s):  
Ozlem Tiryaki ◽  
Celalettin Usalan ◽  
Seval Kul ◽  
Mehmet Tarakcioglu ◽  
Murat Sucu ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Masked Hypertension ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Ventricular Mass Index ◽  
Urinary Angiotensinogen ◽  
Ventricular Mass

Is the burden of late hypertension and cardiovascular target organ damage in children and adolescents with coarctation of the aorta after early successful repair different to healthy controls?

2020 ◽  
Vol 30 (9) ◽  
pp. 1305-1312
Author(s):  
Ayşe Ağbaş ◽  
Selman Gökalp ◽  
Nur Canpolat ◽  
Salim Çalışkan ◽  
Funda Öztunç
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Coarctation Of The Aorta ◽  
Left Ventricular ◽  
Masked Hypertension ◽  
Ventricular Mass Index ◽  
Ventricular Mass ◽  
Successful Repair

AbstractObjective:Cardiovascular morbidity is high in patients with coarctation of aorta even after successful repair. This study aimed to assess the frequency of late hypertension and the relationship between ambulatory hypertension and cardiovascular target organ damage in children and adolescents after early and successful repair of coarctation of the aorta.Methods:Twenty-five children and adolescents (mean age 13.5 ± 3.43 years) with repaired coarctation of the aorta (median age at repair 4 months, arm–leg gradient <20 mmHg) and 16 healthy controls were included. Office and ambulatory blood pressure, pulse wave velocity, and left ventricular mass index were assessed.Results:Both day- and night-time systolic blood pressure standard deviation score and left ventricular mass index were significantly higher in patients compared to controls (p ≤ 0.001 for all), whereas pulse wave velocity did not differ. The prevalence of masked hypertension, isolated nocturnal hypertension, and left ventricular hypertrophy were 40, 28, and 24%, respectively. Left ventricular mass index was higher in patients with sustained hypertension, masked hypertension, and normotension compared to controls (p < 0.05). In multivariate analysis, higher night-time systolic blood pressure standard deviation score was the only independent predictor of left ventricular mass index.Conclusion:The present study reveals a high prevalence of masked hypertension, isolated nocturnal hypertension, and left ventricular hypertrophy in children and adolescents with coarctation of the aorta even after early and successful repair. Ambulatory blood pressure monitoring should be considered to diagnose hypertension. All coarctation of aorta patients should be followed up lifelong and encouraged to establish a healthy lifestyle starting from childhood.

Left ventricular mass of persistent masked hypertension in Hong Kong Chinese adolescents: a 4-year follow-up study

2018 ◽  
Vol 28 (6) ◽  
pp. 837-843 ◽  
Author(s):  
Man-Ching Yam ◽  
Hung-Kwan So ◽  
Sit-Yee Kwok ◽  
Fung-Cheung Lo ◽  
Chi-Fung Mok ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Mass ◽  
Ambulatory Blood Pressure ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Hong Kong Chinese ◽  
Masked Hypertension ◽  
Ventricular Mass Index ◽  
Ventricular Mass

AbstractObjectiveIn our previous study, the prevalence of childhood masked hypertension was 11%. This study aims to assess the left ventricular mass index of persistent masked hypertension and determine the factors of elevated left ventricular mass index in Hong Kong Chinese adolescents from a community cohort.DesignCommunity prospective cohort study, follow-up of a case-control study in community.SubjectsPatients with masked hypertension at baseline were invited to recheck ambulatory blood pressure for the persistence of masked hypertension.ResultsA total of 144 out of 165 patients with masked hypertension in the 2011/2012 ambulatory blood pressure survey consented to participate in the study. In all, 48 patients were found to have persistent masked hypertension by ambulatory blood pressure rechecking and were matched with normotensive controls by sex, age, and body height. The left ventricular mass (117.3±39.9 g versus 87.0±28.2 g versus 102.0±28.2 g) and left ventricular mass index (30.1±8.4 g/m2.7 versus 23.9±6.3 g/m2.7 versus 25.1±5.7 g/m2.7) were significantly higher in the persistent masked hypertension group (p<0.0001) compared with the patients without persistent masked hypertension and controls. In multivariate linear regression analysis, left ventricular mass index was found to be higher in male gender (β=4.874, p<0.0001) and the patients with persistent masked hypertension (β=2.796, p=0.003). In addition, left ventricular mass index was positively associated with body mass index z-score (β=3.045, p<0.0001) and low-density lipoprotein cholesterol concentration (β=1.634, p=0.015).ConclusionsPersistent masked hypertension in adolescents is associated with elevated left ventricular mass index.

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