Incidence, etiology, and significance of acute kidney injury in the early post-kidney transplant period

2015 ◽  
Vol 30 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Romuald Panek ◽  
Karthik K. Tennankore ◽  
Bryce A. Kiberd
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Transplant ◽  
Kidney Injury

scholarly journals First Reported Case in Romania of a Successfully Treated Severe COVID-19 in a Kidney Transplant Recipient: A Focus on Acute Kidney Injury

2020 ◽  
Vol 10 (3) ◽  
pp. 174-179
Author(s):  
Flaviu Tosa ◽  
Roxana Manaila ◽  
Alina Elec ◽  
Tudor Moisoiu ◽  
Liviu Ghervan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Clinical Status ◽  
Organ Transplant ◽  
Treatment Strategies ◽  
Kidney Injury ◽  
Kidney Graft ◽  
Kidney Involvement

As coronavirus disease 2019 (COVID-19) caused by the novel virus SARS-CoV-2 is expanding worldwide, kidney involvement seems to be part of the spectrum of its effects. Moreover, the prognosis of the disease seems to be worse in immunocompromised patients when compared to the general population, with 4–5 times higher mortality rates. However, the overall impact on long-term function of the kidney graft is unknown. We report on a case of a 46-year-old kidney transplant recipient who was successfully treated for severe COVID-19 pneumonia. The clinical course was complicated by transient acute kidney injury, most likely due to tubulo-interstitial involvement, with return to the baseline of the creatinine level by the time of discharge. We discuss the characteristics and differential diagnosis of acute kidney injury, as well as management of immunosuppression in connection with overall clinical status and evolution of kidney function. The case is illustrative for dilemmas that transplant professionals may face in the absence of evidence-based, efficient COVID-19 therapy. The risk-benefit balance of the yet to be approved treatment strategies may be weighed differently in organ transplant recipients owing to their immunocompromised status and potential drug interactions with immunosuppressive therapy.

FP784LONG TERM GRAFT FUNCTION IN KIDNEY TRANSPLANT RECIPIENTS OF DECEASED DONORS WITH ACUTE KIDNEY INJURY

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Reinis Lulle ◽  
Gritane Klinta ◽  
Asare Lasma ◽  
Jushinskis Janis ◽  
Malcevs Aleksandrs ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Transplant ◽  
Graft Function ◽  
Kidney Injury ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Deceased Donors

scholarly journals Validation of Administrative Database Codes for Acute Kidney Injury in Kidney Transplant Recipients

2016 ◽  
Vol 3 ◽  
pp. 108 ◽  
Author(s):  
Amber O. Molnar ◽  
Carl van Walraven ◽  
Eric McArthur ◽  
Dean Fergusson ◽  
Amit X. Garg ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Transplant ◽  
Kidney Injury ◽  
Administrative Database ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Hospital Admission following Acute Kidney Injury in Kidney Transplant Recipients Is Associated with a Negative Impact on Graft Function after 1-Year

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0138944 ◽  
Author(s):  
Thiago Corsi Filiponi ◽  
Lúcio Roberto Requião-Moura ◽  
Eduardo José Tonato ◽  
Ana Cristina Carvalho de Matos ◽  
Alvaro Pacheco e Silva-Filho ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Hospital Admission ◽  
Kidney Transplant ◽  
Negative Impact ◽  
Graft Function ◽  
Kidney Injury ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Impact of deceased donor with acute kidney injury on subsequent kidney transplant outcomes–an ANZDATA registry analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0249000
Author(s):  
Juan Pei ◽  
Yeoungjee Cho ◽  
Yong Pey See ◽  
Elaine M. Pascoe ◽  
Andrea K. Viecelli ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Kidney Transplant ◽  
Graft Failure ◽  
Cox Regression ◽  
Graft Function ◽  
Kidney Injury ◽  
Deceased Donor ◽  
Hazard Ratio

Background The need for kidney transplantation drives efforts to expand organ donation. The decision to accept organs from donors with acute kidney injury (AKI) can result in a clinical dilemma in the context of conflicting reports from published literature. Material and methods This observational study included all deceased donor kidney transplants performed in Australia and New Zealand between 1997 and 2017. The association of donor-AKI, defined according to KDIGO criteria, with all-cause graft failure was evaluated by multivariable Cox regression. Secondary outcomes included death-censored graft failure, death, delayed graft function (DGF) and acute rejection. Results The study included 10,101 recipients of kidneys from 5,774 deceased donors, of whom 1182 (12%) recipients received kidneys from 662 (11%) donors with AKI. There were 3,259 (32%) all-cause graft failures, which included 1,509 deaths with functioning graft. After adjustment for donor, recipient and transplant characteristics, donor AKI was not associated with all-cause graft failure (adjusted hazard ratio [HR] 1.11, 95% CI 0.99–1.26), death-censored graft failure (HR 1.09, 95% CI 0.92–1.28), death (HR 1.15, 95% CI 0.98–1.35) or graft failure when death was evaluated as a competing event (sub-distribution hazard ratio [sHR] 1.07, 95% CI 0.91–1.26). Donor AKI was not associated with acute rejection but was associated with DGF (adjusted odds ratio [OR] 2.27, 95% CI 1.92–2.68). Conclusion Donor AKI stage was not associated with any kidney transplant outcome, except DGF. Use of kidneys with AKI for transplantation appears to be justified.

scholarly journals Management of acute kidney injury in patients with COVID-19 or CKD stage 1-4 patients with acute kidney injury in the COVID-19 pandemic: Adapted clinical guidelines of the Ukrainian Association of Nephrologists and Kidney Transplant Specialists

2020 ◽  
pp. 20-27
Author(s):  
M. Kolesnyk ◽  
I. Dudar ◽  
N. Stepanova ◽  
E. Krasyuk ◽  
Yu. Gonchar ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Acute Kidney Injury ◽  
Mortality Rate ◽  
Medical Care ◽  
Kidney Transplant ◽  
Clinical Guidelines ◽  
Kidney Injury ◽  
Ckd Stage ◽  
Infectious Disease Specialists ◽  
Stage 1

Acute kidney injury (AKI) is diagnosed in 1–40% of the COVID-19 patients; from 2% to 10% of the patients are required renal replacement therapy (RRT). The mortality rate in this category of patients reached 88%. Early AKI detection in the patients with COVID-19, followed by the use of preventive and therapeutic measures to minimize the incidence or progression is a significant key to reduce the mortality rate and transformation of AKI into chronic kidney disease (CKD). The expert group of the Ukrainian Association of Nephrologists and Kidney Transplant Specialists has created the adapted clinical guidelines for the management of acute kidney injury in patients with COVID-19 or CKD stage 1-4 patients with acute kidney injury in the COVID-19 pandemic. These guidelines are intended for family physicians, general practitioners, physicians, cardiologists, nephrologists, intensivists, endocrinologists, infectious disease specialists and other professionals involved in the provision of specialized medical care to the patients with COVID-19. Specialized medical care for AKI patients infected COVID-19 should be provided by a multidisciplinary team, which has to involve nephrologists, infectious disease specialists and intensivists.

scholarly journals Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (21) ◽  
pp. 5162
Author(s):  
Jia-Jin Chen ◽  
George Kuo ◽  
Tao Han Lee ◽  
Huang-Yu Yang ◽  
Hsin Hsu Wu ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Acute Kidney Injury ◽  
Intensive Care ◽  
Kidney Transplant ◽  
Meta Analysis ◽  
Graft Loss ◽  
Kidney Injury ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Kidney Replacement Therapy

The adverse impact of Coronavirus disease 2019 (COVID-19) on kidney function has been reported since the global pandemic. The burden of COVID-19 on kidney transplant recipients, however, has not been systematically analyzed. A systematic review and meta-analysis with a random-effect model was conducted to explore the rate of mortality, intensive care unit admission, invasive mechanical ventilation, acute kidney injury, kidney replacement therapy and graft loss in the adult kidney transplant population with COVID-19. Sensitivity analysis, subgroup analysis and meta-regression were also performed. Results: we demonstrated a pooled mortality rate of 21% (95% CI: 19−23%), an intensive care unit admission rate of 26% (95% CI: 22–31%), an invasive ventilation rate among those who required intensive care unit care of 72% (95% CI: 62–81%), an acute kidney injury rate of 44% (95% CI: 39–49%), a kidney replacement therapy rate of 12% (95% CI: 9–15%), and a graft loss rate of 8% (95% CI: 5–15%) in kidney transplant recipients with COVID-19. The meta-regression indicated that advancing age is associated with higher mortality; every increase in age by 10 years was associated with an increased mortality rate of 3.7%. Regional differences in outcome were also detected. Further studies focused on treatments and risk factor identification are needed.

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