Entecavir treatment in kidney transplant recipients infected with hepatitis B

2014 ◽  
Vol 28 (9) ◽  
pp. 1010-1015 ◽  
Author(s):  
Desmond Y. H. Yap ◽  
Susan Yung ◽  
Colin S. O. Tang ◽  
Wai Kay Seto ◽  
Maggie K. M. Ma ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Immune Complex Mediated Glomerulonephritis with Acute Thrombotic Microangiopathy following Newly Detected Hepatitis B Virus Infection in a Kidney Transplant Recipient

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Tracey Salter ◽  
Hannah Burton ◽  
Sam Douthwaite ◽  
William Newsholme ◽  
Catherine Horsfield ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Kidney Transplant ◽  
Immune Complex ◽  
Thrombotic Microangiopathy ◽  
Hbv Infection ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Vaccine Escape Mutant ◽  
B Virus

Hepatitis B virus (HBV) presents a risk to patients and staff in renal units. To minimise viral transmission, there are international and UK guidelines recommending HBV immunisation for patients commencing renal replacement therapy (RRT) and HBV surveillance in kidney transplant recipients. We report the case of a 56-year-old male who was immunised against HBV before starting haemodialysis. He received a deceased donor kidney transplant three years later, at which time there was no evidence of HBV infection. After a further six years he developed an acute kidney injury; allograft biopsy revealed an acute thrombotic microangiopathy (TMA) with glomerulitis, peritubular capillaritis, and C4d staining. Due to a “full house” immunoprofile, tests including virological screening were undertaken, which revealed acute HBV infection. Entecavir treatment resulted in an improvement in viral load and kidney function. HBV genotyping demonstrated a vaccine escape mutant, suggesting “past resolved” infection that reactivated with immunosuppression, though posttransplant acquisition cannot be excluded. This is the first reported case of acute HBV infection associated with immune complex mediated glomerulonephritis and TMA. Furthermore, it highlights the importance of HBV surveillance in kidney transplant recipients, which although addressed by UK guidelines is not currently practiced in all UK units.

Rituximab and hepatitis B reactivation in HBsAg-negative/ anti-HBc-positive kidney transplant recipients

2017 ◽  
Vol 32 (4) ◽  
pp. 722-729 ◽  
Author(s):  
Juhan Lee ◽  
Jun Yong Park ◽  
Kyu Ha Huh ◽  
Beom Seok Kim ◽  
Myoung Soo Kim ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Hepatitis B Reactivation

scholarly journals Reactivation of Hepatitis B virus in kidney transplant recipients with previous clinically resolved infection: A single-center experience

Nefrología ◽  
2018 ◽  
Vol 38 (5) ◽  
pp. 545-550 ◽  
Author(s):  
Catarina Meng ◽  
Carolina Belino ◽  
Luciano Pereira ◽  
Ana Pinho ◽  
Susana Sampaio ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Single Center ◽  
Kidney Transplant Recipients ◽  
Single Center Experience ◽  
B Virus

scholarly journals POS-768 Hepatitis B reactivation in kidney transplant recipients treated with belatacept

2021 ◽  
Vol 6 (4) ◽  
pp. S335
Author(s):  
C. Schwarz ◽  
A. Morel ◽  
E. Rondeau ◽  
M. Marie ◽  
K. Dahan ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Hepatitis B Reactivation
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