Pre-transplant immune state defined by serum markers and alloreactivity predicts acute rejection after living donor kidney transplantation

2014 ◽  
Vol 28 (9) ◽  
pp. 968-979 ◽  
Author(s):  
Florian W.R. Vondran ◽  
Kai Timrott ◽  
Sonja Kollrich ◽  
Ann-Kristin Steinhoff ◽  
Alexander Kaltenborn ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Acute Rejection ◽  
Living Donor ◽  
Serum Markers ◽  
Donor Kidney ◽  
Living Donor Kidney Transplantation ◽  
Immune State ◽  
Donor Kidney Transplantation ◽  
Living Donor Kidney

Clinical Outcome of Elderly Kidney Transplant Recipients from Spousal Donors

2015 ◽  
Vol 95 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Tomoaki Iwai ◽  
Junji Uchida ◽  
Nobuyuki Kuwabara ◽  
Kazuya Kabei ◽  
Nao Yukimatsu ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Acute Rejection ◽  
Living Donor ◽  
High Rate ◽  
Donor Kidney ◽  
Long Term Outcome ◽  
Living Donor Kidney Transplantation ◽  
Age Related ◽  
Donor Kidney Transplantation ◽  
Living Donor Kidney

Introduction: Patients aged 60 years and older stand for the fastest growing group of patients with end-stage renal disease worldwide, and the need for kidney transplants among this population is rising. In Japan, living donor kidney transplantation is mainly performed to deal with the severe shortage of deceased donors, and the number of spousal transplants is currently increasing. Patients and Methods: A total of 164 patients with ESRD underwent living donor kidney transplantation at our institution, of whom 21 patients aged 60 years and older had spousal kidney transplantation. ABO-incompatible kidney transplantation was performed in 5 of the 21 cases. We analyzed these recipients. Results: Patient and graft survival rates were 100%. The incidence of acute rejection was 23.8%. Eight patients experienced cytomegalovirus viremia, two patients experienced Pneumocystis jiroveci infection, and one experienced bacterial pneumonia. Two patients developed cancers and underwent curative operation after transplantation. Conclusions: Elderly kidney transplantation from spousal donors is associated with age-related immune dysfunction, which may develop infections and malignancies and could be immunologically high risk due to the high rate of ABO-incompatibility and poor histocompatibility. An effort to minimize the adverse effect of immunosuppression and to reduce the risk of acute rejection may be needed for an excellent long-term outcome.

Impact of ABO-Incompatible Living Donor Kidney Transplantation on Patient Survival

2020 ◽  
Vol 76 (5) ◽  
pp. 616-623 ◽  
Author(s):  
Allan B. Massie ◽  
Babak J. Orandi ◽  
Madeleine M. Waldram ◽  
Xun Luo ◽  
Anh Q. Nguyen ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Living Donor ◽  
Patient Survival ◽  
Donor Kidney ◽  
Living Donor Kidney Transplantation ◽  
Donor Kidney Transplantation ◽  
Living Donor Kidney
Sign in / Sign up

Export Citation Format

Share Document