Pattern of resolution of pulmonary hypertension, long-term allograft right ventricular function, and exercise capacity in high-risk heart transplant recipients listed under oral sildenafil

2014 ◽  
Vol 28 (7) ◽  
pp. 837-843 ◽  
Author(s):  
Luca S. De Santo ◽  
Marianna Buonocore ◽  
Federica Agrusta ◽  
Ciro Bancone ◽  
Nicola Galdieri ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
High Risk ◽  
Right Ventricular ◽  
Ventricular Function ◽  
Exercise Capacity ◽  
Heart Transplant ◽  
Right Ventricular Function ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

scholarly journals Dominance of free wall radial motion in global right ventricular function of heart transplant recipients

2018 ◽  
Vol 32 (3) ◽  
pp. e13192 ◽  
Author(s):  
Bálint Károly Lakatos ◽  
Márton Tokodi ◽  
Alexandra Assabiny ◽  
Zoltán Tősér ◽  
Annamária Kosztin ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Ventricular Function ◽  
Heart Transplant ◽  
Right Ventricular Function ◽  
Radial Motion ◽  
Free Wall ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

scholarly journals Decreased pulmonary vascular distensibility in adolescents conceived by in vitro fertilization

2019 ◽  
Vol 34 (9) ◽  
pp. 1799-1808
Author(s):  
K Forton ◽  
Y Motoji ◽  
B Pezzuto ◽  
S Caravita ◽  
A Delbaere ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Aerobic Exercise ◽  
Ventricular Function ◽  
Exercise Capacity ◽  
Right Ventricular Function ◽  
Exercise Echocardiography ◽  
Lung Diffusion ◽  
Diffusion Capacity ◽  
Aerobic Exercise Capacity

Abstract STUDY QUESTION What is the functional relevance of decreased pulmonary vascular distensibility in adolescents conceived by IVF? SUMMARY ANSWER Children born by IVF have a slight decrease in pulmonary vascular distensibility observed during normoxic exercise that is not associated with altered right ventricular function and aerobic exercise capacity. WHAT IS KNOWN ALREADY General vascular dysfunction and increased hypoxic pulmonary hypertension have been reported in ART children as compared to controls. Pulmonary hypertension or decreased pulmonary vascular distensibility may affect right ventricular function and thereby possibly limit maximal cardiac output and aerobic exercise capacity. STUDY DESIGN, SIZE, DURATION This prospective case-control study enrolled 15 apparently healthy adolescents conceived by IVF/ICSI after fresh embryo transfer paired in a 2 to 1 ratio to 30 naturally conceived adolescents between March 2015 and May 2018. PARTICIPANTS/MATERIALS, SETTING, METHODS Fifteen IVF/ICSI adolescents and 30 controls from singleton gestations matched by age, gender, weight, height and physical activity underwent exercise echocardiography, lung diffusion capacity measurements and a cycloergometer cardiopulmonary exercise test. A pulmonary vascular distensibility coefficient α was determined from the pulmonary arterial pressure (PAP) versus cardiac output (Q) relationships. Pulmonary capillary volume (Vc) was calculated from single breath nitric oxide and carbon monoxide lung diffusion capacity measurements (DLCO and DLNO) at rest and during exercise (100 W). Eight of the IVF subjects and eight controls underwent a 30 min hypoxic challenge at rest with a fraction of inspired oxygen of 0.12 to assess hypoxic pulmonary vasoconstriction. MAIN RESULTS AND THE ROLE OF CHANCE In normoxia, oxygen uptake (VO2), blood pressure, DLCO, DLNO, echocardiographic indices of right ventricular function, Q and PAP at rest and during exercise were similar in both groups. However, IVF children had a lower pulmonary vascular distensibility coefficient α (1.2 ± 0.3 versus 1.5 ± 0.3%/mmHg, P = 0.02) and a blunted exercise-induced increase in Vc (24 versus 32%, P < 0.05). Hypoxic-induced increase in pulmonary vascular resistance in eight IVF subjects versus eight controls was similar. LIMITATIONS, REASONS FOR CAUTION The IVF cohort was small, and thus type I or II errors could have occurred in spite of careful matching of each case with two controls. ART evolved over the years, so that it is not certain that the presently reported subtle changes will be reproducible in the future. As the study was limited to singletons born after fresh embryo transfers, our observations cannot be extrapolated to singletons born after frozen embryo transfer. WIDER IMPLICATIONS OF THE FINDINGS The present study suggests that adolescents conceived by IVF have preserved right ventricular function and aerobic exercise capacity despite a slight alteration in pulmonary vascular distensibility as assessed by two entirely different methods, i.e. exercise echocardiography and lung diffusing capacity measurements. However, the long-term prognostic relevance of this slight decrease in pulmonary vascular distensibility needs to be evaluated in prospective large scale and long-term outcome studies. STUDY FUNDING/COMPETING INTEREST(S) Dr Caravita was supported by an ERS PAH short term research training fellowship (STRTF2014-5264). Dr Pezzuto was funded by an Italian Society of cardiology grant. Dr Motoji was supported by a grant from the Cardiac Surgery Funds, Belgium. All authors have no conflicts of interests to declare.

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