Post-transplant lymphoproliferative disorder in adult liver transplant recipients: a South American multicenter experience

2013 ◽  
Vol 27 (4) ◽  
pp. E469-E477 ◽  
Author(s):  
Manuel Mendizabal ◽  
Sebastián Marciano ◽  
Luciana dos Santos Schraiber ◽  
Rodrigo Zapata ◽  
Rodolfo Quiros ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Lymphoproliferative Disorder ◽  
South American ◽  
Transplant Recipients ◽  
Adult Liver ◽  
Post Transplant ◽  
Liver Transplant Recipients

scholarly journals Hypomagnesemia and risk of post‐transplant lymphoproliferative disorder in liver transplant recipients

2020 ◽  
Vol 33 (12) ◽  
pp. 1835-1836
Author(s):  
Parag Mahale ◽  
Gregory J. Mckenna ◽  
Giovanna Saracino ◽  
Linda Jennings ◽  
Sam M. Mbulaiteye ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Lymphoproliferative Disorder ◽  
Transplant Recipients ◽  
Post Transplant ◽  
Liver Transplant Recipients

Single institution experience of post transplant lymphoproliferative disorder in liver transplant recipients.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e19512-e19512
Author(s):  
Yasser Ged ◽  
Ahmed abu Shanab ◽  
Naeem Ullah ◽  
Aidan McCormick ◽  
David William Fennelly ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Lymphoproliferative Disorder ◽  
Transplant Recipients ◽  
Single Institution ◽  
Post Transplant ◽  
Liver Transplant Recipients

scholarly journals Post-Transplant Lymphoproliferative Disorder in Liver Transplant Recipients: Characteristics, Management and Outcome from a Single-Centre Experience with >1000 Liver Transplantations

2015 ◽  
Vol 29 (8) ◽  
pp. 417-422 ◽  
Author(s):  
Khalid Mumtaz ◽  
Nabiha Faisal ◽  
Max Marquez ◽  
Alicia Healey ◽  
Leslie B Lilly ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Median Survival ◽  
Large Volume ◽  
Lymphoproliferative Disorder ◽  
Calcineurin Inhibitor ◽  
Complete Response ◽  
Transplant Recipients ◽  
Actuarial Survival ◽  
Post Transplant ◽  
Liver Transplant Recipients

BACKGROUND: The literature regarding post-transplant lymphoproliferative disorder (PTLD) in liver transplant recipients (LTRs) is limited.OBJECTIVES: To study the incidence, predictors and outcomes of PTLD after liver transplantation in a single, large-volume centre.METHODS: The charts of all LTRs (n=1372) in the authors’ centre between January 2000 and June 2012 were retrospectively reviewed and those who developed PTLD were identified. Demographic, clinical and treatment data were prospectively collected. Responses to treatment, including complete response, no response, relapse and survival, were recorded.RESULTS: The incidence of PTLD in LTRs was 32 in 1372 (2.3%). Overall, median survival was 37 months (range 0.5 to 195 months), with one-, three- and five-year survival rates of 81%, 74% and 60%, respectively. Epstein-Barr virus (EBV)-negative patients had a better mean (± SD) survival (95±79 months) than EBV-positive patients (41±42 months) (P=0.02). For stage I/II PTLD, one-, three- and five-year actuarial survival was 87%, 87% and 75%, compared with 50%, 30% and 0% for stage III/IV PTLD, respectively (P=0.001). In patients with complete response, median survival was 58 months (range 10 to 195 months); and one-, three- and five-year actuarial survival was 100%, 94% and 76%, respectively, after diagnosis of PTLD. Changing immunosuppression (IS) from calcineurin inhibitor to sirolimus at the time of diagnosis may have improved survival (seven of seven survivors) compared with only decreasing or stopping IS (14 of 25 survivors) (P=0.07).CONCLUSIONS: This series from a single large-volume centre showed excellent short and long-term survival after PTLD in adult LTRs who were EBV negative, had early disease and showed complete response. Consistent with the known in vitro antiproliferative effect of sirolimus, switching IS from calcineurin inhibitor to sirolimus may improve survival.

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