Fungal infections after liver transplantation: outcomes and risk factors revisited in the MELD era

2013 ◽  
Vol 27 (4) ◽  
pp. E454-E461 ◽  
Author(s):  
Faouzi Saliba ◽  
Valérie Delvart ◽  
Philippe Ichaï ◽  
Najiby Kassis ◽  
Françoise Botterel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Fungal Infections ◽  
Transplantation Outcomes

Risk Factors for Fungal Infections After Liver Transplantation

2018 ◽  
Vol 102 ◽  
pp. S56
Author(s):  
Dieter Hoyer ◽  
Halil I Karadag ◽  
Andreas Paul ◽  
Fuat H Saner
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Fungal Infections

Adherence to Posttransplantation Medical Regimen

2018 ◽  
Author(s):  
Lauren S Jones ◽  
Marina Serper
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Electronic Monitoring ◽  
Risk Groups ◽  
Current Evidence ◽  
Low Literacy ◽  
Improve Medication Adherence ◽  
Related Factors ◽  
Financial Barriers ◽  
Transplantation Outcomes

In this review, we provide an overview of the most current evidence on the prevalence, risk factors, and consequences of medication non-adherence (NA) in liver transplant recipients. Despite the improvement in long-term liver transplantation outcomes, medication NA is the leading cause of graft failure, graft rejection, and poor clinical outcomes. We examine methods of measuring NA as well as interventions that have been carried out to improve medication adherence and posttransplantation outcomes. Common risk factors for NA include low social support, medication-related factors (eg. side effects), regimen complexity, younger age, financial barriers, and low literacy. Additionally, we discuss special at-risk populations with pretransplantation substance abuse or psychiatric comorbidities as well as adolescents making a transition into adulthood and independent self-care. Multifaceted interventions that are personalized and specific to identified adherence barriers for high-risk groups seem to be the most promising approach to improve medication NA and posttransplantation outcomes. This review contains 4 figures, 5 tables, and 53 references Key Words: electronic monitoring, immunosuppression, liver transplantation, medication, nonadherence, noncompliance, tacrolimus standard deviation, transplantation outcomes

ARMS as a Genotyping PCR, a New Technique for Detection of Liver Transplantation Recipients’ C3FF, C3FS, C3SS Allotypes as Predisposing Factor For Post-Transplantation Infections

2021 ◽  
Vol 30 (1) ◽  
pp. 183-190
Author(s):  
Samah M. Awad ◽  
Sanaa S. Hamam
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Viral Infections ◽  
Fungal Infections ◽  
Microbial Colonization ◽  
Amplification Refractory Mutation System ◽  
Sample Collection ◽  
Post Transplantation ◽  
Predisposing Factor ◽  
Microbiological Methods

Background: Complement is a crucial branch of both non-specific and specific immune system. C3 is the third complement component which plays a protective role in viral infections. There are two co-dominant inherited variants or allotypes for C3: C3 fast (C3F) and C3 slow (C3S). C3F variant has been linked to multiple diseases production including infections among liver transplantation recipients. Objectives: To investigate the most common risk factors for post-liver transplantation infections especially preoperative colonization. To identify types and rates of post-liver transplantation infections and their causing organisms. To identify C3 allotypes for both liver transplantation donors and recipients, and to correlate recipients’ allotypes with post-transplantation infections. Methodology: This study is a prospective study; it was conducted from January 2017 to August 2019 on 64 chronic cirrhotic patients, experienced liver transplantation in the National Liver Institute ICU, Menoufia, Egypt, and their donors. Blood cultures and other samples were collected according to site of infection using standard Microbiological sample collection methods and bacterial isolated were identified by standard microbiological methods using VITEK2 Compact automated ID/AST instrument. CMV IgG and IgM were detected by ELISA method. DNA was extracted and the extract was used for detection of C3S and C3F alleles by using Amplification Refractory Mutation System (ARMS). Results: The most common cause for liver transplantation was HCV related liver cirrhosis (26.56%). Risk factors for postliver transplantation were Pre-operative microbial colonization (100%) and long operative time (9.875±2.45 h). 39.8% of post-transplantation infections occurred during second week post-operatively and the commonest infections were drain infections (29.5%) and urinary tract infection (27.3%). 51.7% of liver transplantation recipients were C3FF, 32.8% were C3FS and 15.6% were C3SS. C3FF recipients showed increased relative risk to develop CMV (5.2) and bacterial & fungal infections (2.2) than other recipients’ allotypes. Conclusion: A comprehensive infectious diseases workup including detection of C3 allotype of the candidate for liver transplantation should be done pre-operatively to early detect and treat infections which can improve the outcome of the operation dramatically and improve patients’ life style. More studies should be done to find out if there is relation between donors’ and recipients’ C3 allotypes as currently no clear data still present.

scholarly journals Prevalence and Risk Factors of Chronic Kidney Disease After Liver Transplantation: Outcomes in The Main Transplant Center of Peru

2021 ◽  
Vol 07 (01) ◽  
Author(s):  
Padilla-Machaca PM ◽  
Gonzales-Hamada L ◽  
Cardenas B ◽  
Cerron C ◽  
Espinoza-Rivera S ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Liver Transplantation ◽  
Kidney Disease ◽  
Transplant Center ◽  
Transplantation Outcomes

Invasive fungal infections following liver transplantation – risk factors, incidence and outcome

2011 ◽  
Vol 16 (3) ◽  
pp. 14-16 ◽  
Author(s):  
Marek J. Pacholczyk ◽  
Beata Lagiewska ◽  
Wojciech Lisik ◽  
Dariusz Wasiak ◽  
Andrzej Chmura
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Fungal Infections ◽  
Invasive Fungal Infections

scholarly journals Spectrum and risk factors for invasive candidiasis and non-Candida fungal infections after liver transplantation

2008 ◽  
Vol 121 (7) ◽  
pp. 625-630 ◽  
Author(s):  
Shao-hua SHI ◽  
An-wei LU ◽  
Yan SHEN ◽  
Chang-ku JIA ◽  
Wei-lin WANG ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Invasive Candidiasis ◽  
Fungal Infections

Epidemiology of invasive fungal infections after liver transplantation and the risk factors of late-onset invasive aspergillosis

2016 ◽  
Vol 22 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Miki Nagao ◽  
Yasuhiro Fujimoto ◽  
Masaki Yamamoto ◽  
Yasufumi Matsumura ◽  
Toshimi Kaido ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Invasive Aspergillosis ◽  
Late Onset ◽  
Fungal Infections ◽  
Invasive Fungal Infections

Risk Factors For Invasive Fungal Infections Complicating Orthotopic Liver Transplantation

1994 ◽  
Vol 170 (3) ◽  
pp. 644-652 ◽  
Author(s):  
L. A. Collins ◽  
M. H. Samore ◽  
M. S. Roberts ◽  
R. Luzzati ◽  
R. L. Jenkins ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Fungal Infections ◽  
Invasive Fungal Infections
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