scholarly journals The comfort assessment in healthy adults during constant‐flow mode in non‐invasive ventilator

2021 ◽  
Author(s):  
Juanjuan Yao ◽  
Wei Li ◽  
Mengmeng Peng ◽  
Kaixin He ◽  
Dedong Ma ◽  
...  
Keyword(s):  
Healthy Adults ◽  
Flow Mode ◽  
Constant Flow ◽  
Non Invasive

Targeted Non-Invasive Neuromodulation Impacts Reward Expectancy-Related Reward Circuitry Activity and Affect in Bipolar Disorder and Healthy Adults

2021 ◽  
Vol 89 (9) ◽  
pp. S38
Author(s):  
Mary Phillips ◽  
Michele Bertocci ◽  
Henry Chase ◽  
Simona Graur ◽  
Richelle Stiffler ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Healthy Adults ◽  
Reward Circuitry ◽  
Non Invasive ◽  
Reward Expectancy

scholarly journals Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Chin-Hung Liu ◽  
Mei-Fang Chen ◽  
Tzu-Ling Tseng ◽  
Lih-Geeng Chen ◽  
Jon-Son Kuo ◽  
...  
Keyword(s):  
Cardiac Dysfunction ◽  
Constant Pressure ◽  
Myocardial Dysfunction ◽  
Flow Mode ◽  
Constant Flow ◽  
Oroxylin A ◽  
Beneficial Effects ◽  
Isolated Hearts ◽  
Cardiac Functions ◽  
Coronary Endothelium

The mortality in septic patients with myocardial dysfunction is higher than those without it. Beneficial effects of flavonoid oroxylin A (Oro-A) on endotoxemic hearts were evaluated and compared with that of arginine vasopressin (AVP) which is used to reverse hypotension in septic patients. Endotoxemia in rats was induced by one-injection of lipopolysaccharides (LPS, 10 mg/kg, i.p.), and hearts were isolated 5-hrs or 16-hrs later. Isolated hearts with constant-pressure or constant-flow mode were examined by Langendorff technique. Rate and force of contractions of isolated atrial and ventricular strips were examined by tissue myography. Isolated endotoxemic hearts were characterized by decreased or increased coronary flow (CF) in LPS-treated-for-5hr and LPS-treated-for-16-hr groups, respectively, with decreased inotropy in both groups. Oro-A-perfusion ameliorated while AVP-perfusion worsened the decreased CF and inotropy in both preparations. Oro-A and AVP, however, did not affect diminished force or rate of contraction of atrial and ventricular strips of endotoxemic hearts. Oro-A-induced CF increase was not affected following coronary endothelium-denudation with saponin. These results suggest that Oro-A ameliorates LPS-depressed cardiac functions by increasing CF, leading to positive inotropy. In contrast, AVP aggravates cardiac dysfunction by decreasing CF. Oro-A is a potentially useful candidate for treating endotoxemia complicated with myocardial dysfunction.

scholarly journals Non-Invasive Respiratory Impedance Enhances Cerebral Perfusion in Healthy Adults

2017 ◽  
Vol 8 ◽  
Author(s):  
Christopher G. Favilla ◽  
Ashwin B. Parthasarathy ◽  
John A. Detre ◽  
Arjun G. Yodh ◽  
Michael T. Mullen ◽  
...  
Keyword(s):  
Cerebral Perfusion ◽  
Healthy Adults ◽  
Respiratory Impedance ◽  
Non Invasive

scholarly journals Acoustic stimulation increases implicit adaptation in sensorimotor adaptation

2020 ◽  
Author(s):  
Li-Ann Leow ◽  
James R. Tresilian ◽  
Aya Uchida ◽  
Dirk Koester ◽  
Tamara Spingler ◽  
...  
Keyword(s):  
Motor Skills ◽  
Brain Stimulation ◽  
Acoustic Stimulation ◽  
Individual Variability ◽  
Healthy Adults ◽  
Sensorimotor Adaptation ◽  
Prediction Errors ◽  
Motor Tasks ◽  
Non Invasive ◽  
Sensory Prediction

AbstractSensorimotor adaptation is an important part of our ability to perform novel motor tasks (i.e., learning of motor skills). Efforts to improve adaptation in healthy and clinical patients using non-invasive brain stimulation methods have been hindered by interindividual and intra-individual variability in brain susceptibility to stimulation. Here, we explore unpredictable loud acoustic stimulation as an alternative method of modulating brain excitability to improve sensorimotor adaptation. In two experiments, participants moved a cursor towards targets, and adapted to a 30° rotation of cursor feedback, either with or without unpredictable acoustic stimulation. Acoustic stimulation improved initial adaptation to sensory prediction errors in Study 1, and improved overnight retention of adaptation in Study 2. Unpredictable loud acoustic stimulation might thus be a potent method of modulating sensorimotor adaptation in healthy adults.

scholarly journals P804Physiological effect of non invasive auricular vagus nerve stimulation on sinus rate in healthy adults subjects

EP Europace ◽  
2018 ◽  
Vol 20 (suppl_1) ◽  
pp. i144-i145
Author(s):  
A Gauthey ◽  
C De Meester ◽  
S Marchandise ◽  
C Scavee ◽  
J B Le Polain De Waroux
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Healthy Adults ◽  
Non Invasive ◽  
Sinus Rate

Detection of any-stage cancer using plasma and urine glycosaminoglycans.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 3034-3034
Author(s):  
Francesco Gatto ◽  
Sinisa Bratulic ◽  
Ilaria Teresa Rita Cavarretta ◽  
Massimo Alfano ◽  
Francesca Maccari ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Cox Regression ◽  
Early Stage ◽  
Healthy Adults ◽  
Low Grade ◽  
Cancer Type ◽  
Liquid Biopsies ◽  
Non Invasive ◽  
Validation Set

3034 Background: Non-invasive liquid biopsies promise to enable early cancer detection and improve patient outcomes. However, virtually all liquid biopsies rely on genomic biomarkers, with limited sensitivity to early-stage tumors and poor detection of cancers shedding little cell-free DNA, like genitourinary or brain tumors. Here, we explored the use of plasma and urine glycosaminoglycan (GAGs) profiles, or GAGomes, as biomarkers reflective of tumor metabolism to serve as an alternative pan-cancer liquid biopsy. Methods: In this case-control study, we enrolled retrospective and prospective cohorts from Sweden and Italy. Included cases were treatment-naïve early-stage/low-grade cancers or metastatic/high-grade cancers across 14 histological types. Included controls were healthy 22-78 y/o adults with no history of cancer. We measured GAGomes – encompassing 17 chondroitin sulfate (CS), heparan sulfate (HS), and hyaluronate (HA) disaccharides - using a standardized UHPLC-MS/MS-based kit in a central blind laboratory. We tested the top GAGome features different in cancer using Bayesian estimation. These were used to design one plasma and one urine GAG score for the binary classification of cancer vs. control in a discovery set. We computed the area-under-the-curve (AUC), and sensitivity at 98% specificity of each GAG score in the validation set. A subset analysis was performed in early-stage/low-grade cancers only. In the subset of cases with survival records, we used multivariable Cox regression to estimate the hazard ratio (HR) for overall survival (OS) on each GAG score adjusted for cancer type, age, and gender. Results: GAGomes were measured in 753 plasma samples (460 cancers across 14 types, median age = 66 y/o, 51% female vs. 293 healthy adults, median age = 58 y/o, 57% female) and 559 urine samples (219 cancers across 5 types, median age = 69 y/o, 23% female vs. 340 healthy adults, median age = 56 y/o, 60% female). In the discovery set, the urine GAG score had an AUC = 0.80 (95% CI: 0.74-0.85, 124 cancers across 5 types vs. 184 controls) while the plasma GAG score had an AUC = 0.82 (95% CI: 0.78-0.86, 153 cancers across 14 types vs. 282 controls). In the validation set, the urine GAG score had an AUC = 0.78 (95% CI: 0.71-0.84, 95 cancers across 5 types vs. 156 controls) with 35% sensitivity at 98% specificity. The plasma GAG score had an AUC = 0.84 (95% CI: 0.79-0.88, 178 cancers across 14 types vs. 140 controls) with 41% sensitivity at 98% specificity. In the subset of early-stage/low-grade cancers, the AUC was 0.78 and 0.72 in plasma and urine, respectively. The plasma and urine GAG scores were independent predictors of OS regardless of cancer type (HR = 1.39, p = 0.005 in plasma [ N = 283, 11 types, 67 deaths, median follow-up 17 months] and HR = 1.53, p = 0.016 in urine [ N = 161, 4 types, 32 deaths, median follow-up 15 months]). Conclusions: GAGomes were sensitive non-invasive metabolic biomarkers for any-stage cancer, including genitourinary and brain tumors.

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