Clinical and CT findings of adenovirus pneumonia in immunocompetent adults

Author(s):  
Peiyao Zhang ◽  
Min Liu ◽  
Ling Zhang ◽  
Xiaojuan Guo ◽  
Binghuai Lu ◽  
...  
2020 ◽  
Author(s):  
Peiyao Zhang ◽  
Min Liu ◽  
Ling Zhang ◽  
Xiaojuan Guo ◽  
Binghuai Lu ◽  
...  

Abstract Background: Adenovirus pneumonia account for 5%–10% of respiratory tract infections in children. However, it is rarely observed in immunocompetent patients. We sought to describe clinical and CT characteristics of community-acquired Adenovirus pneumonia in immunocompetent adults.Methods: 20 patients with clinically diagnosed adenovirus pneumonia from two hospitals were retrospectively included from January 2018 to December 2019. Medical records and chest CT of all patients were reviewed and summarized.Results: A total of 20 patients who were consisted of 18 men and 2 women with a median age of 36 years-old (range, 18-48). The clinical findings of patients with adenovirus pneumonia is high fever (>39oC) with the normal white blood cell (WBC) count and decreased Lymphocyte and elevated C-reactive protein. 10 cases complicated with mycoplasma infection when admission. Staphylococcus epidermidis was found in blood culture of 2 patients. CT findings included consolidation in all patients, ground glass opacity (GGO) in 13 patients, and pleural effusion in 12 patients. 13 patients were mechanically ventilated and 2 patients died during hospitalization.Conclusions: The most frequent finding of adenovirus pneumonia on CT was consolidation in the early stage. In adult patients with high fever, normal WBC count and decreased Lymphocyte, consolidation with/without GGO in the early stage may be a clue for suspecting adenovirus pneumonia.


2016 ◽  
Vol 8 (5) ◽  
pp. 848-854 ◽  
Author(s):  
Dingyu Tan ◽  
Yangyang Fu ◽  
Jun Xu ◽  
Zhiwei Wang ◽  
Jian Cao ◽  
...  

2006 ◽  
Vol 186 (5) ◽  
pp. 1288-1293 ◽  
Author(s):  
Semin Chong ◽  
Kyung Soo Lee ◽  
Tae Sung Kim ◽  
Myung Jin Chung ◽  
Man Pyo Chung ◽  
...  

2020 ◽  
pp. 088506662096068
Author(s):  
Seong Mi Moon ◽  
Junsu Choe ◽  
Soo Jin Na ◽  
Chi Ryang Chung ◽  
Gee Young Suh ◽  
...  

Background: Adenovirus infection can cause severe pneumonia even in immunocompetent adults. However, there is limited data on the benefits of cidofovir treatment in severe adenovirus pneumonia. The objective of this study was to evaluate the association of cidofovir treatment with clinical improvement in immunocompetent adult patients with severe adenovirus pneumonia. Methods: We evaluated 22 male patients who admitted to intensive care unit (ICU) with severe adenovirus pneumonia between January 2014 and December 2019. The patients were divided into 2 groups, patients treated with cidofovir or not. Clinical outcomes including time to defervescence and stopping of oxygen supplement, length of stay in ICU and hospital, and the need for mechanical ventilation (MV) and extracorporeal membrane oxygenation (ECMO) were compared between the 2 groups. Results: Among 22 patients, 13 patients (59%) were treated with cidofovir and 9 (41%) were not. The difference in mean time (95% confidence interval [CI]) to defervescence and stopping of oxygen supplement between cidofovir group and no cidofovir group was 2.1 (−5.7 to 10.0) and 1.0 (−14.9 to 16.8) days, respectively. The difference in mean length of stay (95% CI) in ICU and hospital between the 2 groups was 0.2 (−7.1 to 7.5) and −0.4 (−18.3 to 17.5) days, respectively. The differences in proportion of patients requiring MV and ECMO between the 2 groups was 28.2 (−17.4 to 73.8) % and −10.3 (−52.2 to 31.7) %, respectively. Conclusions: The treatment with cidofovir for severe adenovirus pneumonia in immunocompetent patients did not improve clinical outcomes. Further studies with larger samples with prospective design are warranted.


2016 ◽  
Vol 55 (01) ◽  
pp. N1-N3
Author(s):  
C. Ferrari ◽  
A. Niccoli Asabella ◽  
C. Altini ◽  
G. Rubini
Keyword(s):  
Fdg Pet ◽  
Pet Ct ◽  
18F Fdg ◽  

1991 ◽  
Vol 30 (05) ◽  
pp. 161-169 ◽  
Author(s):  
C. Weiller ◽  
R. Weigmann ◽  
H.-J. Kaiser ◽  
U. Büll ◽  
R. Schneider ◽  
...  

Lacunar infarctions and periventricular hypodensity are assumed to be typical CT patterns of cerebral microangiopathy (MA). In 17 patients with such findings and in 6 controls without any signs of central nervous system disease cranial CT, MRT and 99mTc-HMPAO-SPECT were employed. In 7 patients with CT findings of minor MA demonstrated in comparison to controls no significant difference. In 10 cases with CT findings of pronounced MA periventricular rCBF was significantly reduced compared to controls. rCBF of temporal and parietal cortex were not diminished compared to controls. In 14 patients studied with MRT deep white matter lesions were found which appeared solitary, multiple or confluent. Employing 99mTc-HMPAO-SPECT, cerebral MA revealed rCBF reduction in periventricular brain tissue by cerebellar standardization.


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