Increased risk for cardiovascular disease in patients with obstructive sleep apnoea syndrome‐chronic obstructive pulmonary disease (overlap syndrome)

2019 ◽  
Vol 13 (11) ◽  
pp. 708-715 ◽  
Author(s):  
Athanasios Voulgaris ◽  
Kostas Archontogeorgis ◽  
Nikolaos Papanas ◽  
Eleni Pilitsi ◽  
Evangelia Nena ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Sleep Apnoea ◽  
Overlap Syndrome ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Obstructive Sleep ◽  
Increased Risk

Cardiovascular Disease in Patients with Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnoea Syndrome and Overlap Syndrome

2020 ◽  
Vol 19 (3) ◽  
pp. 285-300
Author(s):  
A. Voulgaris ◽  
K. Archontogeorgis ◽  
P. Steiropoulos ◽  
N. Papanas
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Overlap Syndrome ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Obstructive Sleep

: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea syndrome (OSAS) are among the most prevalent chronic respiratory disorders. Accumulating data suggest that there is a significant burden of cardiovascular disease (CVD) in patients with COPD and OSAS, affecting negatively patients’ quality of life and survival. Overlap syndrome (OS), i.e. the co-existence of both COPD and OSAS in the same patient, has an additional impact on the cardiovascular system multiplying the risk of morbidity and mortality. The underlying mechanisms for the development of CVD in patients with either OSAS or COPD and OS are not entirely elucidated. Several mechanisms, in addition to smoking and obesity, may be implicated, including systemic inflammation, increased sympathetic activity, oxidative stress and endothelial dysfunction. Early diagnosis and proper management of these patients might reduce cardiovascular risk and improve patients' survival. In this review, we summarize the current knowledge regarding epidemiological aspects, pathophysiological mechanisms and present point-to-point specific associations between COPD, OSAS, OS and components of CVD, namely, pulmonary hypertension, coronary artery disease, peripheral arterial disease and stroke.

scholarly journals Comparison of invasive intubation and noninvasive mechanical ventilation in patients with chronic obstructive pulmonary disease and obstructive sleep apnoea syndrome

2021 ◽  
Vol 49 (12) ◽  
pp. 030006052110683
Author(s):  
Wenjing Liu ◽  
Hong Guo ◽  
Fang Ding ◽  
Zhaobo Cui ◽  
Juxiang Zhang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Obstructive Sleep Apnoea ◽  
Noninvasive Ventilation ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep

Objective The concurrence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea syndrome (OSAS) is defined as overlap syndrome (OS), but investigations into predictors of OS in patients with COPD remain limited. Here, potential markers of OS in patients with COPD were investigated, and results of intubation were compared between patients with COPD only or OS. Methods This retrospective study included patients with COPD who were divided according to OS diagnosis: COPD only (COPD group) or OS (OS group). Results Among 206 patients with COPD, 120 were diagnosed with OS. Mean body mass index (BMI) was significantly higher in the OS versus COPD group (28.95 ± 2.96 versus 23.84 ± 4.06, respectively). Receiver operating characteristic curve analyses revealed that BMI was associated with OS (area under the curve, 0.835). The rate of invasive intubation within 48 h was lower in the OS versus COPD group (9.2% versus 20.9%, respectively), and the duration of noninvasive ventilation was longer in the OS versus COPD group. Conclusions BMI may be a predictor of OS in patients with COPD. The duration of noninvasive ventilation was longer in patients with OS than in patients with COPD alone.

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