The prognostic significance of tricuspid valve regurgitation in pulmonary arterial hypertension

2017 ◽  
Vol 12 (4) ◽  
pp. 1572-1580 ◽  
Author(s):  
Libo Chen ◽  
Carolyn M. Larsen ◽  
Rachel J. Le ◽  
Heidi M. Connolly ◽  
Sorin V. Pislaru ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Tricuspid Valve ◽  
Prognostic Significance ◽  
Valve Regurgitation ◽  
Tricuspid Valve Regurgitation ◽  
Pulmonary Arterial

Pulmonary Arterial Hypertension and Tricuspid Valve Regurgitation as Manifestations of Hyperthyroidism Resulting From Graves Disease

2005 ◽  
Vol 15 (5) ◽  
pp. 300-302 ◽  
Author(s):  
Leonardo Vieira Neto ◽  
Carla Amaral de Almeida ◽  
In??s Donangelo ◽  
Sabrina Mendes Coelho ◽  
Alexandru Buescu ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Tricuspid Valve ◽  
Graves Disease ◽  
Valve Regurgitation ◽  
Tricuspid Valve Regurgitation ◽  
Pulmonary Arterial

scholarly journals Follow-up tricuspid annular plane systolic excursion predicts survival in pulmonary arterial hypertension

2017 ◽  
Vol 7 (2) ◽  
pp. 361-371 ◽  
Author(s):  
Jeremy A. Mazurek ◽  
Anjali Vaidya ◽  
Stephen C. Mathai ◽  
Justin D. Roberts ◽  
Paul R. Forfia
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Prognostic Significance ◽  
Functional Class ◽  
Heart Catheterization ◽  
Pulmonary Arterial ◽  
Group 2 ◽  
One Year ◽  
Group 1

Few studies have examined the utility of serial echocardiography in the evaluation, management, and prognosis of patients with pulmonary arterial hypertension (PAH). Therefore, we sought to evaluate the prognostic significance of follow-up tricuspid annular plane systolic excursion (TAPSE) in PAH. We prospectively studied 70 consecutive patients with PAH who underwent baseline right heart catheterization (RHC) and transthoracic echocardiogram, who survived to follow-up echocardiogram after initiation of PAH therapy. Baseline TAPSE was 1.6 ± 0.5 cm which increased to 2.0 ± 0.4 cm on follow-up ( P < 0.0001). The cohort was dichotomized by TAPSE at one-year follow-up: Group 1 (n = 37): follow-up TAPSE ≥ 2 cm; Group 2 (n = 33): follow-up TAPSE < 2 cm. Group 1 participants were significantly more likely to reach WHO functional class I–II status and achieve a higher six-minute walk distance on follow-up. Of the 68 patients who survived more than one year, 18 died (26.5%) over a median follow-up of 941 days (range, 3–2311 days), with significantly higher mortality in Group 2 versus Group 1 (41.9% vs. 13.5%; P = 0.003). While baseline TAPSE stratified at 2 cm did not predict survival in this cohort, TAPSE ≥ 2 cm at follow-up strongly predicted survival in bivariable models (hazard ratio, 0.21; 95% confidence interval, 0.08–0.60). In conclusion, follow-up TAPSE ≥ 2 cm is a prognostic marker and potential treatment target in a PAH population.

scholarly journals 151 Prognostic significance of moderate renal dysfunction in patients with pulmonary arterial hypertension

2011 ◽  
Vol 3 (1) ◽  
pp. 49
Author(s):  
Mathieu Canuet ◽  
Laurence Jesel ◽  
Annie Trinh ◽  
Sandrine Bentzinger ◽  
Bruno Moulin ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Renal Dysfunction ◽  
Prognostic Significance ◽  
Pulmonary Arterial

scholarly journals Social deprivation and prognosis in Scottish patients with pulmonary arterial hypertension

2018 ◽  
Vol 51 (2) ◽  
pp. 1700444 ◽  
Author(s):  
Katherine Pellino ◽  
Simon Kerridge ◽  
Colin Church ◽  
Andrew J. Peacock ◽  
Timothy Crowe ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Low Socioeconomic Status ◽  
Social Deprivation ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Cox Proportional Hazards ◽  
Pulmonary Arterial ◽  
The Impact

Several demographic and clinical factors have prognostic significance in idiopathic pulmonary arterial hypertension (IPAH). Studies in China and the USA have suggested an association between low socioeconomic status and reduced survival. The impact of social deprivation on IPAH survival in the UK is not known.280 patients with IPAH and hereditary PAH (HPAH) attending the Scottish Pulmonary Vascular Unit (Glasgow, UK) were assigned to social deprivation quintiles using the Scottish Index of Multiple Deprivation database. The association between survival and social deprivation quintile was assessed using Cox proportional hazards regression analysis.The distribution of IPAH/HPAH patients was more socially deprived than would be expected based on Scottish citizenry as a whole (Chi-squared 16.16, p=0.003), suggesting referral and access to care is not impeded by socioeconomic status. Univariate analysis demonstrated no significant association between social deprivation and survival (p=0.81), and this association failed to reach significance with inclusion of time, sex and age as covariates in the model (p=0.23). There were no statistically significant correlations between social deprivation and baseline clinical variables of prognostic importance except for age, sex and quality of life.Social deprivation is not a significant referral barrier or prognostic factor for IPAH and HPAH in Scotland.

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