Diagnostic value of soluble B7-H4 and carcinoembryonic antigen in distinguishing malignant from benign pleural effusion

2017 ◽  
Vol 12 (3) ◽  
pp. 986-990 ◽  
Author(s):  
Xiaogang Jing ◽  
Fei Wei ◽  
Jing Li ◽  
Lingling Dai ◽  
Xi Wang ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Diagnostic Value ◽  
Benign Pleural Effusion

Diagnostic value of carcinoembryonic antigen in malignant pleural effusion: A meta-analysis

Respirology ◽  
2008 ◽  
Vol 13 (4) ◽  
pp. 518-527 ◽  
Author(s):  
Huan-Zhong SHI ◽  
Qiu-Li LIANG ◽  
Jing JIANG ◽  
Xue-Jun QIN ◽  
Hai-Bo YANG
Keyword(s):  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Malignant Pleural Effusion ◽  
Meta Analysis ◽  
Diagnostic Value

scholarly journals Reactive oxygen species modulator 1, a novel protein, combined with carcinoembryonic antigen in differentiating malignant from benign pleural effusion

Tumor Biology ◽  
2017 ◽  
Vol 39 (5) ◽  
pp. 101042831769837 ◽  
Author(s):  
Xianmeng Chen ◽  
Na Zhang ◽  
Jiahui Dong ◽  
Gengyun Sun
Keyword(s):  
Reactive Oxygen Species ◽  
Differential Diagnosis ◽  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Sensitivity And Specificity ◽  
Malignant Pleural Effusion ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cutoff Value ◽  
Benign Pleural Effusion

The differential diagnosis of malignant pleural effusion and benign pleural effusion remains a clinical problem. Reactive oxygen species modulator 1 is a novel protein overexpressed in various human tumors. The objective of this study was to evaluate the diagnostic value of joint detection of reactive oxygen species modulator 1 and carcinoembryonic antigen in the differential diagnosis of malignant pleural effusion and benign pleural effusion. One hundred two consecutive patients with pleural effusion (including 52 malignant pleural effusion and 50 benign pleural effusion) were registered in this study. Levels of reactive oxygen species modulator 1 and carcinoembryonic antigen were measured by enzyme-linked immunosorbent assay and radioimmunoassay, respectively. Results showed that the concentrations of reactive oxygen species modulator 1 both in pleural fluid and serum of patients with malignant pleural effusion were significantly higher than those of benign pleural effusion (both p < 0.05). The diagnostic sensitivity and specificity of pleural fluid reactive oxygen species modulator 1 were 61.54% and 82.00%, respectively, with the optimized cutoff value of 589.70 pg/mL. However, the diagnostic sensitivity and specificity of serum reactive oxygen species modulator 1 were only 41.38% and 86.21%, respectively, with the cutoff value of 27.22 ng/mL, indicating that serum reactive oxygen species modulator 1 may not be a good option in the differential diagnosis of malignant pleural effusion and benign pleural effusion. The sensitivity and specificity of pleural fluid carcinoembryonic antigen were 69.23% and 88.00%, respectively, at the cutoff value of 3.05 ng/mL, while serum carcinoembryonic antigen were 80.77% and 72.00% at the cutoff value of 2.60 ng/mL. The sensitivity could be raised to 88.17% in parallel detection of plural fluid reactive oxygen species modulator 1 and carcinoembryonic antigen concentration, and the specificity could be improved to 97.84% in serial detection.

scholarly journals Auxiliary diagnostic value of tumor biomarkers in pleural fluid for lung cancer-associated malignant pleural effusion

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Hai Zhang ◽  
Changhui Li ◽  
Fang Hu ◽  
Xueyan Zhang ◽  
Yinchen Shen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pleural Effusion ◽  
Pleural Fluid ◽  
Malignant Pleural Effusion ◽  
Compliance Rate ◽  
Diagnostic Value ◽  
Tumor Biomarkers ◽  
Training Set ◽  
Test Set ◽  
Benign Pleural Effusion

Abstract Background Pleural effusion (PE) can be divided into benign pleural effusion (BPE) and malignant pleural effusion (MPE). There is no consensus on the identification of lung cancer-associated MPE using the optimal cut-off levels from five common tumor biomarkers (CEA, CYFRA 21-1, CA125, SCC-Ag, and NSE). Therefore, we aimed to find indicators for the auxiliary diagnosis of lung cancer-associated MPE by analyzing and then validating the optimal threshold levels of these biomarkers in pleural fluid (PF) and serum, as well as the PF/serum ratio. Patients and method The study has two sets of patients, i.e. the training set and the test set. In the training set, 348 patients with PE, between January 1, 2016 and December 31, 2017, were divided into BPE and MPE based on the cytological diagnosis. Subsequently, the optimal cut-off levels of tumor biomarkers were analyzed. In the test set, the diagnostic compliance rate was verified with 271 patients with PE from January 1, 2018 to July 31, 2019 to evaluate the auxiliary diagnostic value of the aforementioned indicators. Result In the training set, PF CEA at the cut-off value of 5.23 ng/ml was the most effective indicator for MPE compared with other tumor biomarkers (all p < 0.001). In the test set, PF CEA at the cut-off value of 5.23 ng/ml showed the highest sensitivity, specificity and accuracy, positive and negative predictive value among other tumor biomarkers, which were 99.0%, 69.1%, 91.6%, 90.7%, and 95.9%, respectively. Conclusion PF CEA at the cut-off level of 5.23 ng/ml was the most effective indicator for identifying lung cancer-associated MPE among the five common tumor biomarkers.

scholarly journals Ratio of carcinoembryonic antigen in pleural fluid and serum for the diagnosis of malignant pleural effusion

2019 ◽  
Vol 11 ◽  
pp. 175883591985034 ◽  
Author(s):  
Klaus Hackner ◽  
Peter Errhalt ◽  
Sabin Handzhiev
Keyword(s):  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Pleural Fluid ◽  
Predictive Value ◽  
Malignant Pleural Effusion ◽  
Diagnostic Value ◽  
Tumour Markers ◽  
Operating Characteristics ◽  
Characteristics Analysis ◽  
Individual Marker

Background: Tumour markers in pleural fluid and their diagnostic value are subject to debate. Although there are several studies on this topic, standardized cut-off values do not exist. In this study we investigated the potential of a ratio of carcinoembryonic antigen (CEA) in pleural fluid and serum, serving as an individual marker for pleural cancer manifestation. Methods: A total of 201 consecutive patients with unclear pleural effusion were included in the study; 98 were diagnosed with malignant pleural effusion and 103 had an effusion due to other, benign reasons. CEA levels in pleural fluid and serum were measured. Results: By using receiver operating characteristics analysis, at the cut-off of 1.0, the CEA ratio showed a specificity of 92% and sensitivity of 85%, with a positive predictive value of 91% and a negative predictive value of 87%. These results are higher than in previous investigations on different pleural tumour markers and their combination. Conclusions: The CEA ratio is a useful tool in predicting pleural carcinosis. Elevated results in cytology-negative patients should lead to further investigations, such as repeated cytological examination or thoracoscopy.

Diagnostic Potential of Carcinoembryonic Antigen and Ferritine in Tuberculous and Malignant Pleural Effusion

1995 ◽  
Vol 81 (6) ◽  
pp. 440-444 ◽  
Author(s):  
Robert Loncar ◽  
Ljerka Ostojic ◽  
Vera Tabakovic-Loncar ◽  
Ante Roguljić
Keyword(s):  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Sensitivity And Specificity ◽  
Malignant Pleural Effusion ◽  
Bayes Theorem ◽  
Diagnostic Value ◽  
Physical Status ◽  
Predictive Values ◽  
Diagnostic Potential ◽  
Significant Difference

The aim of the study was to determine the diagnostic value of carcinoembryonic antigen (CEA) and ferritine in malignant and tuberculous non-bloody pleural effusion. The etiology of diseases was determined by cytologic, histologic and microbiologic methods. CEA concentration above 5 ng/ml and ferritine concentration above 200 ng/ml were considered to be positive. There was significant difference in the value of CEA measured in malignant and in tuberculous pleural effusion (P < 0.005) as well as in the sera (P < 0.01) of these two groups. There was no correlation between concentration of CEA and ferritine in malignant pleural effusion. Ratio between CEA and ferritine in effusions and sera was of no help in discrminating malignant from tuberculous effusions. No correlation between examined markers and physical status of patients was observed. The sensitivity and specificity of CEA assay in malignant pleural effusion was 65% and 90%, respectively, and for ferritine 67% and 80%, respectively. A high correlation was observed between the CEA concentration in malignant pleural effusion and sera patients (r = 0.95). Combined sensitivity and specificity of CEA and ferritine was 65.9% and 85%. Bayes theorem was used to calculate the positive predictive values for CEA and ferritine, which were 53% and 37%, respectively. Results obtained in the study show the relatively good diagnostic potential of CEA.

scholarly journals Diagnostic value of tumour markers Ca-125 and CEA in the diagnostics of malignant pleural fluids

2016 ◽  
Vol 70 (2) ◽  
pp. 41-46
Author(s):  
Dace Žentiņa ◽  
Inga Stuķēna ◽  
Sarma Grīnberga ◽  
Alvils Krams ◽  
Aivars Lejnieks
Keyword(s):  
Pleural Effusion ◽  
Pleural Fluid ◽  
Diagnostic Value ◽  
Tumour Markers ◽  
Ca 125 ◽  
Differential Diagnostics ◽  
Cancer Antigen 125 ◽  
Diagnostic Significance ◽  
Tuberculous Pleurisy ◽  
Benign Pleural Effusion

Abstract The significance of carbohydrate (cancer) antigen 125 (Ca-125) and carcinoembryonic antigen (CEA) tumour markers levels in differential diagnostics of malignant and benign pleural effusion was studied. Within this prospective study, 121 patients with fluids of various aetiology in the pleural cavity were analysed. Malignant pleural effusion was detected in 55 patients, parapneumonic effusion in 28 patients, transudative effusion of cardiac origin in 31 patients, pancreatitis in one patient and tuberculous pleurisy in five patients. The highest accuracy in diagnosis of malignancy was observed for Ca-125 and CEA levels in the pleural fluid: 75.2% at cut-off value ≥1452 U/mL and 76.9% at cut-off value ≥6.58 ng/mL, respectively. We conclude that the level of tumour markers in pleural fluid has additional diagnostic significance in the differential diagnosis of malignant and benign pleural effusions.

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