scholarly journals NLRX1/FUNDC1/NIPSNAP1‐2 axis regulates mitophagy and alleviates intestinal ischaemia/reperfusion injury

2021 ◽  
Author(s):  
Shaoqin Li ◽  
Yi Zhou ◽  
Xiaocheng Gu ◽  
Xiaoping Zhang ◽  
Zhongzhi Jia
Keyword(s):  
Reperfusion Injury ◽  
Intestinal Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Short-interval postconditioning protects the bowel against ischaemia–reperfusion injury in rats

2017 ◽  
Vol 45 (3) ◽  
pp. 1036-1041
Author(s):  
Sezen Ozkisacik ◽  
Ali Onur Erdem ◽  
Barlas Etensel ◽  
Canten Tataroglu ◽  
Mukadder Serter ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Short Interval ◽  
Intestinal Damage ◽  
Protective Effects ◽  
Intestinal Ischaemia ◽  
Long Term Effects ◽  
Ischaemia Reperfusion Injury ◽  
Optimal Interval ◽  
Ischaemia Reperfusion ◽  
Male Wistar Rats

Objective Acute mesenteric ischaemia leads to intestinal damage. Restoration of blood flow results in further damage to tissue, which is called reperfusion injury. This study aimed to investigate the protective effects of short-interval postconditioning and to determine the optimal interval for reperfusion in an experimental rat model of intestinal ischaemia. Methods Forty adult male Wistar rats were grouped as follows: sham (Sh), ischaemia + reperfusion (IR), ischaemia + postconditioning for 5 seconds (PC5), ischaemia + postconditioning for 10 seconds (PC10), and ischaemia + postconditioning for 20 seconds (PC20). For postconditioning, 10 cycles of reperfusion (5, 10, or 20 seconds) interspersed by 10 cycles of 10 seconds of ischaemia were performed. Blood glutathione reductase (GR) and glutathione peroxidase (GPx) levels were measured. Intestinal tissue damage was assessed histopathologically. Results GR levels were significantly higher in the PC5 group than in the IR group (37.7 ± 9.0 vs. 18.5 ± 2.0 min/g Hb). GPx levels were significantly higher in the PC10 group than in the IR group (43.2 ± 9.2 vs. 15.9 ± 4.6 U/g Hb). The histopathological score was significantly lower in the PC5 group (1.1 ± 0.1) than in the IR group (2.1 ± 0.2). Conclusion Short-interval postconditioning reduces reperfusion injury in the ischaemic bowel and the optimal interval for reperfusion is 5 seconds. The long-term effects of short-interval postconditioning and the optimal reperfusion interval in intestinal ischaemia–reperfusion in rats need to be investigated.

Hypothermia throughout intestinal ischaemia-reperfusion injury attenuates lung neutrophil infiltration

2003 ◽  
Vol 38 (1) ◽  
pp. 88-91 ◽  
Author(s):  
Simona Vinardi ◽  
Agostino Pierro ◽  
Emma J. Parkinson ◽  
Paisarn Vejchapipat ◽  
Giorgio Stefanutti ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Neutrophil Infiltration ◽  
Intestinal Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Plasma von Willebrand Factor and Intestinal Ischaemia-Reperfusion Injury in Rats

1999 ◽  
Vol 94 (6) ◽  
pp. 353-358 ◽  
Author(s):  
Fikri M Abu-Zidan ◽  
Glenn Farrant ◽  
L.Jonathan Zwi ◽  
Misho O Simovic ◽  
Tony Day ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Von Willebrand Factor ◽  
Intestinal Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Von Willebrand ◽  
Willebrand Factor
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