scholarly journals IGFBP7 acts as a negative regulator of RANKL‐induced osteoclastogenesis and oestrogen deficiency‐induced bone loss

2019 ◽  
Vol 53 (2) ◽  
Author(s):  
Chenyi Ye ◽  
Weiduo Hou ◽  
Mo Chen ◽  
Jinwei Lu ◽  
Erman Chen ◽  
...  
Keyword(s):  
Bone Loss ◽  
Negative Regulator ◽  
Oestrogen Deficiency

scholarly journals Factors influencing bone loss in anorexia nervosa: assessment and therapeutic options

RMD Open ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e001009 ◽  
Author(s):  
Isabelle Legroux ◽  
Bernard Cortet
Keyword(s):  
Anorexia Nervosa ◽  
Bone Loss ◽  
Mineral Density ◽  
Related Factors ◽  
Oestrogen Treatment ◽  
Oestrogen Deficiency ◽  
Resumption Of Menses ◽  
Main Factor

Decreased mineral density is one of the major complications of anorexia nervosa. The phenomenon is even more pronounced when the disease occurs during adolescence and when the duration of amenorrhoea is long. The mechanisms underlying bone loss in anorexia are complex. Oestrogen deficiency has long been considered as the main factor, but cannot explain the phenomenon on its own. The essential role of nutrition-related factors—especially leptin and adiponectin—has been reported in recent studies. Therapeutic strategies to mitigate bone involvement in anorexia are still a matter for debate. Although resumption of menses and weight recovery appear to be essential, they are not always accompanied by a total reversal of bone loss. There are no studies in the literature demonstrating that oestrogen treatment is effective, and the best results seem to have been obtained with agents that induce bone formation—such as IGF-1—especially when associated with oestrogen. As such, bone management in anorexia remains difficult, hence, the importance of early detection and multidisciplinary follow-up.

scholarly journals Corilagin suppresses RANKL‐induced osteoclastogenesis and inhibits oestrogen deficiency‐induced bone loss via the NF‐κB and PI3K/AKT signalling pathways

2020 ◽  
Vol 24 (18) ◽  
pp. 10444-10457
Author(s):  
Jinwei Lu ◽  
Chenyi Ye ◽  
Yanyong Huang ◽  
Donghui Huang ◽  
Lan Tang ◽  
...  
Keyword(s):  
Bone Loss ◽  
Signalling Pathways ◽  
Oestrogen Deficiency

scholarly journals Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells

2010 ◽  
Vol 159 (4) ◽  
pp. 939-949 ◽  
Author(s):  
Sao-Keng Mok ◽  
Wen-Fang Chen ◽  
Wan-Ping Lai ◽  
Ping-Chung Leung ◽  
Xin-Luan Wang ◽  
...  
Keyword(s):  
Bone Loss ◽  
Oestrogen Receptor ◽  
Oestrogen Deficiency ◽  
Umr 106

RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency‐related bone loss

2019 ◽  
Vol 31 (2) ◽  
pp. e12687 ◽  
Author(s):  
Nicola J. Lee ◽  
Ireni M. Clarke ◽  
Ayse Zengin ◽  
Ronaldo F. Enriquez ◽  
Vanj Nagy ◽  
...  
Keyword(s):  
Bone Loss ◽  
Neuropeptide Y ◽  
Oestrogen Deficiency

scholarly journals Icariin prevents oestrogen deficiency–induced alveolar bone loss through promoting osteogenesis via STAT3

2020 ◽  
Vol 53 (2) ◽  
Author(s):  
Hongyuan Xu ◽  
Siru Zhou ◽  
Ranyi Qu ◽  
Yiling Yang ◽  
Xinyi Gong ◽  
...  
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Oestrogen Deficiency

scholarly journals VISTA Blockade Aggravates Bone Loss in Experimental Murine Apical Periodontitis

2021 ◽  
Vol 12 ◽  
Author(s):  
Fuhua Yang ◽  
Yifei Zhang ◽  
Zhi Chen ◽  
Lu Zhang
Keyword(s):  
T Cells ◽  
Bone Loss ◽  
T Cell Activation ◽  
Cell Activation ◽  
Apical Periodontitis ◽  
Negative Regulator ◽  
Checkpoint Molecule ◽  
Experimental Mouse

V-domain Ig suppressor of T cell activation (VISTA) is a novel coinhibitory immune checkpoint molecule that maintains immune homeostasis. The present study explored the role of VISTA in human and murine inflammatory tissues of apical periodontitis (AP). VISTA was upregulated in inflammatory tissues of human AP. In mice, the expression of VISTA gradually increased with the development of mouse experimental apical periodontitis (MAP), the CD3+ T cells, CD11b+ myeloid cells, and FOXP3+ regulatory T cells also gradually accumulated. Moreover, a blockade of VISTA using a mouse in vivo anti-VISTA antibody aggravated periapical bone loss and enhanced the infiltration of immune cells in an experimental mouse periapical periodontitis model. The collective results suggest that VISTA serves as a negative regulator of the development and bone loss of apical periodontitis.

scholarly journals The Oxysterol, 27-Hydroxycholesterol, Links Cholesterol Metabolism to Bone Homeostasis Through Its Actions on the Estrogen and Liver X Receptors

Endocrinology ◽  
2011 ◽  
Vol 152 (12) ◽  
pp. 4691-4705 ◽  
Author(s):  
Erik R. Nelson ◽  
Carolyn D. DuSell ◽  
Xiaojuan Wang ◽  
Matthew K. Howe ◽  
Glenda Evans ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Mineral ◽  
Cholesterol Metabolism ◽  
Lifestyle Changes ◽  
Negative Regulator ◽  
Liver X Receptors ◽  
Bone Homeostasis ◽  
Mineral Density ◽  
Age Related ◽  
X Receptors

Osteoporosis and age-related bone loss are important public health concerns. Therefore, there is a high level of interest in the development of medical interventions and lifestyle changes that reduce the incidence of osteoporosis and age-related bone loss. Decreased bone mineral density is associated with high cholesterol, and patients on statins have increased bone mineral densities, strongly implicating cholesterol as a negative regulator of bone homeostasis. In this study, using both molecular and pharmacological approaches, we have been able to demonstrate that the primary cholesterol metabolite, 27-hydroxycholesterol, through its actions on both estrogen receptors and liver X receptors, decreases osteoblast differentiation and enhances osteoclastogenesis, resulting in increased bone resorbtion in mice. Induction of the short heterodimer partner protein by estrogens in osteoblasts can attenuate the liver X receptor-mediated actions of 27-hydroxycholesterol in bone. These data establish a mechanistic link between cholesterol and bone quality, highlight an unexpected target of estrogens in osteoblasts, and define a signaling axis, the therapeutic exploitation of which is likely to yield novel antiosteoporotic drugs.

scholarly journals Oestrogen-deficiency induces bone loss by modulating CD14+ monocyte and CD4+ T cell DR3 expression and serum TL1A levels

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Fraser L. Collins ◽  
Michael D. Stone ◽  
Jane Turton ◽  
Laura R. McCabe ◽  
Eddie C. Y. Wang ◽  
...  
Keyword(s):  
T Cell ◽  
Bone Loss ◽  
Cd4 T Cell ◽  
Oestrogen Deficiency
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