scholarly journals Effect of substrate stiffness on proliferation and differentiation of periodontal ligament stem cells

2018 ◽  
Vol 51 (5) ◽  
pp. e12478 ◽  
Author(s):  
Nanxin Liu ◽  
Mi Zhou ◽  
Qi Zhang ◽  
Li Yong ◽  
Tao Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Periodontal Ligament ◽  
Substrate Stiffness ◽  
Periodontal Ligament Stem Cells ◽  
Proliferation And Differentiation

scholarly journals Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Lihua Yin ◽  
Wenxiao Cheng ◽  
Zishun Qin ◽  
Hongdou Yu ◽  
Zhanhai Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Periodontal Ligament ◽  
Trabecular Structure ◽  
Control Group ◽  
Periodontal Ligament Stem Cells ◽  
Expression Levels ◽  
Proliferation And Differentiation

This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2,COL1A2, OPN, and OCN) had significantly higher expression levels compared to the control group. Furthermore, a typical trabecular structure was observed in vivo, surrounded by a large amount of osteoblasts. These results demonstrated that naringin, at a concentration of 1 μM, can efficiently promote the proliferation and differentiation of hPDLSCs both in vitro and in vivo.

scholarly journals Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Wenjun Zhu ◽  
Min Liang
Keyword(s):  
Stem Cells ◽  
Periodontal Ligament ◽  
Periodontal Regeneration ◽  
Culture Conditions ◽  
Careful Consideration ◽  
Current Status ◽  
Periodontal Ligament Stem Cells ◽  
Differentiation Potential ◽  
Promising Tool ◽  
Proliferation And Differentiation

Periodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. Recently, great progress has been made in PDLSC transplantation. Investigators are attempting to maximize the proliferation and differentiation potential of PDLSCs by modifying culture conditions and applying growth factors. Nevertheless, problems remain. First, incomparability among different studies must be minimized by establishing standard guidelines for culture and identification of PDLSCs. Notably, attention should be paid to the biological safety of PDLSC transplantation. The present review updates the latest findings regarding PDLSCs and discusses standard criteria for culture and identification of PDLSCs. Finally, the review calls for careful consideration of PDLSC transplantation safety.

scholarly journals Domain of Dentine Sialoprotein Mediates Proliferation and Differentiation of Human Periodontal Ligament Stem Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e81655 ◽  
Author(s):  
Alkan Ozer ◽  
Guohua Yuan ◽  
Guobin Yang ◽  
Feng Wang ◽  
Wentong Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Periodontal Ligament ◽  
Periodontal Ligament Stem Cells ◽  
Proliferation And Differentiation
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