scholarly journals Extremely low-frequency electromagnetic fields accelerates wound healing modulating MMP-9 and inflammatory cytokines

2018 ◽  
Vol 51 (2) ◽  
pp. e12432 ◽  
Author(s):  
A. Patruno ◽  
A. Ferrone ◽  
E. Costantini ◽  
S. Franceschelli ◽  
M. Pesce ◽  
...  
Keyword(s):  
Wound Healing ◽  
Electromagnetic Fields ◽  
Inflammatory Cytokines ◽  
Low Frequency ◽  
Extremely Low Frequency

scholarly journals Human Gingival Fibroblasts Exposed to Extremely Low-Frequency Electromagnetic Fields: In Vitro Model of Wound-Healing Improvement

2019 ◽  
Vol 20 (9) ◽  
pp. 2108 ◽  
Author(s):  
Erica Costantini ◽  
Bruna Sinjari ◽  
Chiara D’Angelo ◽  
Giovanna Murmura ◽  
Marcella Reale ◽  
...  
Keyword(s):  
Wound Healing ◽  
Electromagnetic Field ◽  
Electromagnetic Fields ◽  
Wound Repair ◽  
Healing Process ◽  
Low Frequency ◽  
Gingival Fibroblasts ◽  
Field Exposure ◽  
Extremely Low Frequency

Several clinical studies have suggested the impact of sinusoidal and pulsed electromagnetic fields in quickening wound repair processes and tissue regeneration. The clinical use of extremely low-frequency electromagnetic fields could represent a novel frontier in tissue repair and oral health, with an interesting clinical perspective. The present study aimed to evaluate the effect of an extremely low-frequency sinusoidal electromagnetic field (SEMF) and an extremely low-frequency pulsed electromagnetic field (PEMF) with flux densities of 1 mT on a model of oral healing process using gingival fibroblasts. An in vitro mechanical injury was produced to evaluate wound healing, migration, viability, metabolism, and the expression of selected cytokines and protease genes in fibroblasts exposed to or not exposed to the SEMF and the PEMF. Interleukin 6 (IL-6), transforming growth factor beta 1 (TGF-β), metalloproteinase 2 (MMP-2), monocyte chemoattractant protein 1 (MCP-1), inducible nitric oxide synthase (iNOS), and heme oxygenase 1 (HO-1) are involved in wound healing and tissue regeneration, favoring fibroblast proliferation, chemotaxis, and activation. Our results show that the exposure to each type of electromagnetic field increases the early expression of IL-6, TGF-β, and iNOS, driving a shift from an inflammatory to a proliferative phase of wound repair. Additionally, a later induction of MMP-2, MCP-1, and HO-1 was observed after electromagnetic field exposure, which quickened the wound-healing process. Moreover, electromagnetic field exposure influenced the proliferation, migration, and metabolism of human gingival fibroblasts compared to sham-exposed cells. This study suggests that exposure to SEMF and PEMF could be an interesting new non-invasive treatment option for wound healing. However, additional studies are needed to elucidate the best exposure conditions to provide the desired in vivo treatment efficacy.

Extremely low-frequency electromagnetic fields activate the antioxidant pathway Nrf2 in a Huntington's disease-like rat model

2013 ◽  
Vol 6 (1) ◽  
pp. 84-86 ◽  
Author(s):  
Inmaculada Tasset ◽  
Aleyda Pérez-Herrera ◽  
Francisco J. Medina ◽  
Óscar Arias-Carrión ◽  
René Drucker-Colín ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Electromagnetic Fields ◽  
Rat Model ◽  
Low Frequency ◽  
Extremely Low Frequency

Neural stimulation on human bone marrow-derived mesenchymal stem cells by extremely low frequency electromagnetic fields

2012 ◽  
Vol 28 (5) ◽  
pp. 1329-1335 ◽  
Author(s):  
Hyunjin Cho ◽  
Young-Kwon Seo ◽  
Hee-Hoon Yoon ◽  
Soo-Chan Kim ◽  
Sung-Min Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Electromagnetic Fields ◽  
Low Frequency ◽  
Neural Stimulation ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Extremely Low Frequency
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