scholarly journals Transient receptor potential melastatin 4 channel is required for rat dental pulp stem cell proliferation and survival

2017 ◽  
Vol 50 (5) ◽  
pp. e12360 ◽  
Author(s):  
T.D. Ngoc Tran ◽  
K.E. Stovall ◽  
T. Suantawee ◽  
Y. Hu ◽  
S. Yao ◽  
...  
Author(s):  
Frederic Torossian ◽  
Aurelie Bisson ◽  
Jean-Pierre Vannier ◽  
Olivier Boyer ◽  
Marek Lamacz

AbstractTransient receptor potential canonical (TRPC) channels are key players in calcium homeostasis and various regulatory processes in cell biology. Little is currently known about the TRPC subfamily members in mesenchymal stem cells (MSC), where they could play a role in cell proliferation. We report on the presence of TRPC1, 2, 4 and 6 mRNAs in MSC. Western blot and immunofluorescence staining indicate a membrane and intracellular distribution of TRPC1. Furthermore, the decrease in the level of TRPC1 protein caused by RNA interference is accompanied by the downregulation of cell proliferation. These results indicate that MSC express TRPC1, 2, 4 and 6 mRNA and that TRPC1 may play a role in stem cell proliferation.


Stem Cells ◽  
2012 ◽  
Vol 31 (1) ◽  
pp. 167-177 ◽  
Author(s):  
Piper Nelson ◽  
Tran Doan Ngoc Tran ◽  
Hanjie Zhang ◽  
Olga Zolochevska ◽  
Marxa Figueiredo ◽  
...  

2017 ◽  
Vol 15 (6) ◽  
pp. 4326-4332 ◽  
Author(s):  
Songbo Tian ◽  
Xiaochao Tian ◽  
Yanping Liu ◽  
Fusheng Dong ◽  
Jie Wang ◽  
...  

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