scholarly journals Induction of apoptosis and G2/M cell cycle arrest byScrophularia striatain a human leukaemia cell line

2013 ◽  
Vol 46 (6) ◽  
pp. 637-643 ◽  
Author(s):  
A. Azadmehr ◽  
R. Hajiaghaee ◽  
M. Mazandarani
1982 ◽  
Vol 46 (3) ◽  
pp. 392-396 ◽  
Author(s):  
K Totsuka ◽  
K Oshimi ◽  
H Mizoguchi

Nature ◽  
1979 ◽  
Vol 278 (5702) ◽  
pp. 364-365 ◽  
Author(s):  
LEIF C. ANDERSSON ◽  
MIKKO JOKINEN ◽  
CARL G. GAHMBERG

2018 ◽  
Vol 61 (11) ◽  
pp. 837-846 ◽  
Author(s):  
Chandan Kumar ◽  
Rohit Sharma ◽  
Tapas Das ◽  
Aruna Korde ◽  
Haladhar Sarma ◽  
...  

2014 ◽  
Vol 9 (1) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Antonio J. León-González ◽  
Margaret M. Manson ◽  
Miguel López-Lázaro ◽  
Inmaculada Navarro ◽  
Carmen Martín-Cordero

The leaves of Corema album (Ericaceae), an endemic shrub which grows in Atlantic coastal areas of the Iberian Peninsula, are rich in flavonoids and other secondary metabolites. Silica gel column chromatography of the ethyl acetate extract from dried leaves was performed and a flavonic active fraction was obtained. The cytotoxic activity of this fraction was assessed using the colon cancer cell lines HCT116 and HT29. After 48 hours of treatment, cell viability was determined with luminescence-based ATPLite assay, showing IC50 values of 7.2 ± 0.7 and 6.8 ± 1.2 μg/mL, respectively. The study by flow cytometry revealed that the cytotoxicity of this fraction was mediated, at least in part, by induction of apoptosis and G2/M cell cycle arrest. The active fraction was then subjected to Sephadex LH-20 chromatography and two flavonoids were separated and identified as the flavanone pinocembrin and 2′,4′-dihydroxychalcone after UV, MS and NMR analysis.


Life Sciences ◽  
2004 ◽  
Vol 75 (23) ◽  
pp. 2829-2839 ◽  
Author(s):  
Eun-Jin Lee ◽  
Hye-Young Min ◽  
Hyen Joo Park ◽  
Hwa-Jin Chung ◽  
Sanghee Kim ◽  
...  

2013 ◽  
Vol 146 (2) ◽  
pp. 525-535 ◽  
Author(s):  
Nurdin Armania ◽  
Latifah Saiful Yazan ◽  
Siti Noorhidayah Musa ◽  
Intan Safinar Ismail ◽  
Jhi Biau Foo ◽  
...  

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