82 Rb Tissue kinetics in humans

2021 ◽  
Author(s):  
Sima Gregg ◽  
Georgia Keramida ◽  
A. Michael Peters
Keyword(s):  
Tissue Kinetics

The Tissue Kinetics and Residues of Chloramphenicol in Sokoto Red Goats

2005 ◽  
Vol 2 (1) ◽  
pp. 24-27
Author(s):  
E.U. Etuk . ◽  
P.A. Onyeyili .
Keyword(s):  
Tissue Kinetics

Cell and Tissue Kinetics

2014 ◽  
pp. 249-258
Author(s):  
David S. Chang ◽  
Foster D. Lasley ◽  
Indra J. Das ◽  
Marc S. Mendonca ◽  
Joseph R. Dynlacht
Keyword(s):  
Tissue Kinetics

Bone Tissue Kinetics in the Surgically Disarticulated Dog Incus

1993 ◽  
Vol 113 (2) ◽  
pp. 181-186 ◽  
Author(s):  
M. Roberto ◽  
A. Favia ◽  
E. Lozupone
Keyword(s):  
Bone Tissue ◽  
Tissue Kinetics

Size-dependent tissue kinetics of PEG-coated gold nanoparticles

2010 ◽  
Vol 245 (1) ◽  
pp. 116-123 ◽  
Author(s):  
Wan-Seob Cho ◽  
Minjung Cho ◽  
Jinyoung Jeong ◽  
Mina Choi ◽  
Beom Seok Han ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Size Dependent ◽  
Kinetics Of ◽  
Tissue Kinetics

scholarly journals Antiretroviral Tissue Kinetics: In Vivo Imaging Using Positron Emission Tomography

2009 ◽  
Vol 53 (10) ◽  
pp. 4086-4095 ◽  
Author(s):  
Michele Di Mascio ◽  
Sharat Srinivasula ◽  
Abesh Bhattacharjee ◽  
Lily Cheng ◽  
Lucia Martiniova ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Lymph Nodes ◽  
Coefficient Of Variation ◽  
Emission Tomography ◽  
Intersubject Variability ◽  
Positron Emission ◽  
Antiretroviral Drug ◽  
Kinetics In Vivo ◽  
Tissue Kinetics

ABSTRACT Our current knowledge on the antiviral efficacy, dosing, and toxicity of available highly active antiretroviral therapy regimens is mostly derived from plasma or blood kinetics of anti-human immunodeficiency virus (anti-HIV) drugs. However, the blood comprises only 2% of the total target cells in the body. Tissue drug levels may differ substantially from corresponding plasma levels, and drug distribution processes may be characterized by high intertissue variability, leading to suboptimal target site concentrations and the potential risk for therapeutic failures. Positron emission tomography has greatly expanded the scope of the pharmacokinetic measurements that can be performed noninvasively in animal models or humans. We have prepared [18F]FPMPA, a fluorine-18-radiolabeled analogue of tenofovir, to study antiretroviral tissue kinetics in vivo noninvasively and tested the imaging probe in rats. The biodistribution of the fluorine-18 analogue closely follows that of nonfluorinated tenofovir. Compared to that in the blood, the levels of penetration of the antiretroviral drug were found to be significantly reduced in the spleen and submandibular lymph nodes (∼2-fold), in the mesenteric lymph nodes and the testes (∼4-fold), and in the brain compartment (∼25-fold). Intersubject variability of the trough drug concentration (measured at 120 min) in certain tissues, like the colon (coefficient of variation, >100%), is not reflected by the intersubject variability in the blood compartment (coefficient of variation, 24%). Positron emission tomography imaging of the fluorine-18 analogue revealed the accumulation of the antiretroviral drug in the cortex of the kidneys, a potential correlate of tenofovir-induced nephrotoxicity observed in HIV-1-infected treated patients. Thus, [18F]FPMPA is a promising radiotracer for evaluation of tenofovir biodistribution under carefully controlled drug administration protocols.

scholarly journals Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment

2007 ◽  
Vol 115 (9) ◽  
pp. 1339-1343 ◽  
Author(s):  
Raymond S.H. Yang ◽  
Louis W. Chang ◽  
Jui-Pin Wu ◽  
Ming-Hsien Tsai ◽  
Hsiu-Jen Wang ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Quantitative Assessment ◽  
Icp Ms ◽  
Tissue Kinetics

Comparative adipose tissue kinetics of thiopental, DDE and 2,4,5,2′,4′,5′-hexachlorobiphenyl in the rat

Xenobiotica ◽  
1985 ◽  
Vol 15 (6) ◽  
pp. 485-491 ◽  
Author(s):  
S. Mühlebach ◽  
P. A. Wyss ◽  
M. H. Bickel
Keyword(s):  
Adipose Tissue ◽  
Kinetics Of ◽  
Tissue Kinetics
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