Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

2018 ◽  
Vol 39 (1) ◽  
pp. 65-77 ◽  
Author(s):  
Daria Frestad Bechsgaard ◽  
Ida Gustafsson ◽  
Jesper James Linde ◽  
Klaus Fuglsang Kofoed ◽  
Eva Prescott ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Myocardial Perfusion ◽  
Cardiac Computed Tomography

Integration Between Computed Tomography and Nuclear Medicine for Non-invasive Assessment of Coronary Anatomy and Myocardial Perfusion

2009 ◽  
Vol 5 (2) ◽  
pp. 15
Author(s):  
Wanda Acampa ◽  
Mario Petretta ◽  
Carmela Nappi ◽  
Alberto Cuocolo ◽  
◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Blood Flow ◽  
Heart Disease ◽  
Myocardial Perfusion ◽  
Myocardial Blood Flow ◽  
Imaging Techniques ◽  
Emission Computed Tomography ◽  
Coronary Anatomy ◽  
Non Invasive

Many non-invasive imaging techniques are available for the evaluation of patients with known or suspected coronary heart disease. Among these, computed-tomography-based techniques allow the quantification of coronary atherosclerotic calcium and non-invasive imaging of coronary arteries, whereas nuclear cardiology is the most widely used non-invasive approach for the assessment of myocardial perfusion. The available single-photon-emission computed tomography flow agents are characterised by a cardiac uptake proportional to myocardial blood flow. In addition, different positron emission tomography tracers may be used for the quantitative measurement of myocardial blood flow and coronary flow reserve. Extensive research is being performed in the development of non-invasive coronary angiography and myocardial perfusion imaging using cardiac magnetic resonance. Finally, new multimodality imaging systems have recently been developed bringing together anatomical and functional information. This article provides a description of the available non-invasive imaging techniques in the assessment of coronary anatomy and myocardial perfusion in patients with known or suspected coronary heart disease.

scholarly journals Evidence of association of circulating epigenetic-sensitive biomarkers with suspected coronary heart disease evaluated by Cardiac Computed Tomography

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0210909 ◽  
Author(s):  
Teresa Infante ◽  
Ernesto Forte ◽  
Concetta Schiano ◽  
Bruna Punzo ◽  
Filippo Cademartiri ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiac Computed Tomography

Correlation of Circulating miR-765, miR-93-5p, and miR-433-3p to Obstructive Coronary Heart Disease Evaluated by Cardiac Computed Tomography

2019 ◽  
Vol 124 (2) ◽  
pp. 176-182 ◽  
Author(s):  
Teresa Infante ◽  
Ernesto Forte ◽  
Bruna Punzo ◽  
Filippo Cademartiri ◽  
Carlo Cavaliere ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiac Computed Tomography

P6431Association of circulating miR-765, miR-93-5p and miR-433-3p with obstructive coronary heart disease evaluated by cardiac computed tomography

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Infante ◽  
E Forte ◽  
B Punzo ◽  
F Cademartiri ◽  
C Cavaliere ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Clinical Decision Making ◽  
Cardiac Computed Tomography ◽  
Venous Blood ◽  
Preventive Treatment ◽  
Circulating Microrna ◽  
Roc Curve Analysis ◽  
Mortality And Morbidity

Abstract Background Although advances in diagnosis, treatment and prognosis, coronary heart disease (CHD) is still the most prevalent cause of mortality and morbidity worldwide. Thus, there is still the need to identify both novel diagnostic and prognostic biomarkers to improve the clinical decision-making and help to stratify patients for early preventive treatment. Epigenetic-sensitive mechanisms may be related both to pathogenesis and prognosis of CHD. Among the epigenetic hallmarks, microRNAs (miRNAs), acting as flexible modulators of gene expression, could represent attractive candidate biomarkers useful in clinical practice. Purpose We prospectively investigated the expression pattern of circulating miRNAs in patients undergoing Cardiac Computed Tomography (CCT) for suspected CHD (n=95) with the aim to integrate molecular findings with morphological and clinical parameters derived by CCT. Methods CCT was performed with a third-generation dual source multidetector computed tomography scanner. Peripheral venous blood samples were collected into EDTA after a 12 h fasting in the same day of CCT, before imaging execution and the levels of 42 selected plasmatic miRNAs were analyzed by qRT-PCR. Results Let-7c-5p, miR-765, miR-483-5p, miR-31-5p and miR-206 were upregulated in CHD patients (n=66) vs healthy subjects HS (n=29) as well as let-7c-5p, miR-765, miR- 483-5p showed higher expression in obstructive CHD (n=36) compared to no obstructive CHD patients (n=66). In addition, miR-93-5p and miR-433-3p showed an upregulation in patients with critical coronary stenosis. Multivariate regression analysis demonstrated that miR-765, miR-31-5p and miR-206 were independently associated with CHD also in combination with Framingham risk score. Relevantly, miR-765, miR-93-5p and miR-433-3p were obstructive CHD predictors. ROC curve analysis also revealed a good performance for miR-765, miR-93-5p and miR-433-3p on predicting CHD severity. Circulating microRNA expression Conclusions Our study represents a combined epigenetic/imaging approach useful to support the diagnosis and prediction of CHD. Acknowledgement/Funding Italian Ministry of Health grants: “Giovani Ricercatori 2011-12” (project code GR-2011-02349436) and “Ricerca Corrente 2018”

Cardiac computed tomography for the interventionalist

2018 ◽  
pp. 177-190
Author(s):  
Adriaan Coenen ◽  
Laurens E. Swart ◽  
Ricardo P. J. Budde ◽  
Koen Nieman
Keyword(s):  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Computed Tomography Angiography ◽  
Interventional Procedures ◽  
Coronary Computed Tomography Angiography ◽  
Cardiac Computed Tomography ◽  
Invasive Procedure ◽  
Coronary Computed Tomography ◽  
Technological Developments

Coronary computed tomography angiography (CTA) is a method used to eliminate the possibility of coronary heart disease in a patient without an invasive procedure. Technological developments mean that CTA also produces less radiation than ever before, making it safer for both the patient and the practitioner. This chapter covers the principles and protocols in cardiac computed tomography (CT), guidance on interpreting the resulting images, and summarizes studies on the use of CT after various interventional procedures.

Radiogenomics and Artificial Intelligence Approaches Applied to Cardiac Computed Tomography Angiography and Cardiac Magnetic Resonance for Precision Medicine in Coronary Heart Disease: A Systematic Review

2021 ◽  
Author(s):  
Teresa Infante ◽  
Carlo Cavaliere ◽  
Bruna Punzo ◽  
Vincenzo Grimaldi ◽  
Marco Salvatore ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Computed Tomography Angiography ◽  
Cardiac Computed Tomography ◽  
Imaging Features ◽  
Cardiac Computed Tomography Angiography

The risk of coronary heart disease (CHD) clinical manifestations and patient management is estimated according to risk scores accounting multifactorial risk factors, thus failing to cover the individual cardiovascular risk. Technological improvements in the field of medical imaging, in particular, in cardiac computed tomography angiography and cardiac magnetic resonance protocols, laid the development of radiogenomics. Radiogenomics aims to integrate a huge number of imaging features and molecular profiles to identify optimal radiomic/biomarker signatures. In addition, supervised and unsupervised artificial intelligence algorithms have the potential to combine different layers of data (imaging parameters and features, clinical variables and biomarkers) and elaborate complex and specific CHD risk models allowing more accurate diagnosis and reliable prognosis prediction. Literature from the past 5 years was systematically collected from PubMed and Scopus databases, and 60 studies were selected. We speculated the applicability of radiogenomics and artificial intelligence through the application of machine learning algorithms to identify CHD and characterize atherosclerotic lesions and myocardial abnormalities. Radiomic features extracted by cardiac computed tomography angiography and cardiac magnetic resonance showed good diagnostic accuracy for the identification of coronary plaques and myocardium structure; on the other hand, few studies exploited radiogenomics integration, thus suggesting further research efforts in this field. Cardiac computed tomography angiography resulted the most used noninvasive imaging modality for artificial intelligence applications. Several studies provided high performance for CHD diagnosis, classification, and prognostic assessment even though several efforts are still needed to validate and standardize algorithms for CHD patient routine according to good medical practice.

scholarly journals The study of myocardial perfusion by cardiac volumetric computed tomography, combined with adenosine triphosphate test, in a patient with painless myocardial ischemia and atherosclerosis of the coronary arteries

2020 ◽  
Vol 92 (4) ◽  
pp. 76-79
Author(s):  
G. N. Soboleva ◽  
S. A. Gaman ◽  
S. K. Ternovoy ◽  
Yu. A. Karpov ◽  
A. A. Minasyan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Myocardial Perfusion ◽  
Myocardial Ischemia ◽  
Adenosine Triphosphate ◽  
Coronary Arteries ◽  
Clinical Observation ◽  
Pharmacological Test ◽  
Volumetric Ct

The presented clinical observation demonstrates the diagnostic capabilities of cardiac volumetric computed tomography (CT) with a pharmacological test by a vasodilator adenosine triphosphate (ATP) in the simultaneous assessment of coronary anatomy and changes in left ventricular myocardial perfusion (LV) in a patient with painless myocardial ischemia and coronary atherosclerosis. A 68-year-old patient with coronary heart disease (CHD) and atherosclerotic changes in the coronary arteries underwent cardiac volumetric CT in combination with a ATP pharmacological test. The study was performed on a Aquilion ONE 640 Vision Edition computer tomograph (Toshiba, Japan). Assessment of LV myocardial perfusion was carried out in comparison with other clinical, laboratory and instrumental examination methods. The results of clinical and instrumental examination of a patient with a low pre-test probability of coronary heart disease are presented. From the standpoint of modern recommendations on stable coronary heart disease, false-negative results of single-photon emission computed tomography of the heart and stress-echocardiography are discussed. Clinical observation demonstrates the feasibility of diagnosing LV myocardial ischemia by cardiac volumetric CT combined with ATP pharmacological test, confirmed by an invasive determination of the fractional flow reserve. The given clinical example represents the advantage of cardiac volumetric CT, combined with the ATP pharmacological test, as a method for visualizing LV myocardial perfusion in detecting myocardial ischemia.

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